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Histopathological and biochemical changes in the sutural region in craniosynostosis

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Abstract 

Object: Histopathological observations and biochemical analysis of sutural bones in nine patients with craniosynostosis were compared with control subjects of the same age range. Methods: Microscopic examination in craniosynostosis showed formation of an active osseous front, with higher osteoblastic activity than in controls. Biochemical analysis revealed higher calcium, phosphorus, alkaline phosphatase, phospholipids and chon-droitin sulphate-A contents in sutural bones of the same patients. Conclusions: The present study systematically establishes a pre- mature increase in osteogenesis in the sutures of craniosynostosis patients.

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Authors and Affiliations

  1. Department of Neurosurgery, Postgraduate Institute of Medical, Education and Research, Chandigarh 160 012, India e-mail: medinst@pgi.chd.nic.in Fax: +91-172-540401, , , , , , IN

    A. Pathak & V. K. Kak

  2. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India, , , , , , IN

    B. K. Sandhu & R. Nath

  3. Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India, , , , , , IN

    B. D. Radotra

  4. Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India, , , , , , IN

    N. Khandelwal

Authors
  1. A. Pathak
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  2. B. K. Sandhu
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  3. B. D. Radotra
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  4. N. Khandelwal
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  5. R. Nath
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  6. V. K. Kak
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Received: 27 September 1999

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Pathak, A., Sandhu, B., Radotra, B. et al. Histopathological and biochemical changes in the sutural region in craniosynostosis. Child's Nerv Syst 16, 564–568 (2000). https://doi.org/10.1007/s003810000270

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  • DOI: https://doi.org/10.1007/s003810000270

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