Skip to main content
SpringerLink
Log in

Changes in interhemispheric coherence after total corpus callosotomy: a scalp EEG study in children with non-lesional generalized epilepsy

  • Research
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Purpose

Coherence analysis in electroencephalography (EEG) allows measurement of the degree of consistency of amplitude between pairs of electrodes. Theoretically, disconnective epilepsy surgery should decrease coherence between corresponding areas. The study aimed to evaluate postoperative changes in interhemispheric coherence values after corpus callosotomy (CC).

Methods

Non-lesional, drug-resistant, generalized epilepsy patients who underwent total CC were retrospectively collected. To evaluate coherence, we divided the scalp interictal EEG into “baseline” and “discharge” states after excluding periods with artifacts. Interhemispheric coherence values were obtained between eight pairs of symmetrically opposite scalp electrodes in six different frequency bands. We analyzed both pre- and postoperative EEG sessions and calculated the percentage of difference (POD) in coherence values.

Results

We collected 13 patients and analyzed 2496 interhemispheric coherence values. Preoperative coherence values differed significantly between baseline and discharge states (p = 0.0003), but postoperative values did not (p = 0.11). For baseline state, coherence values were decreased after CC and median POD was − 22.3% (p < 0.0001). Delta frequency showed the most decreased POD (-44.3%, p = 0.0009). Median POD was lowest in the Fp1-Fp2 pair of electrodes. For discharge state, coherence values were decreased after CC and median POD was − 24.7% (p < 0.0001). Delta frequency again showed the most decreased POD (-55.9%, p = 0.0016). Median POD was lowest in the F7-F8 pair.

Conclusion

After total CC, interhemispheric coherence decreased significantly in both baseline and discharge states. The most decreased frequency band was the delta band, which may be used as a representative frequency band in future studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Data availability

No datasets were generated or analysed during the current study.

References

  1. Uda T, Kunihiro N, Umaba R, Koh S, Kawashima T, Ikeda S, Ishimoto K, Goto T (2021) Surgical aspects of corpus callosotomy. Brain Sci 11(12):1608. https://doi.org/10.3390/brainsci11121608. PMID: 34942910

  2. Thohar Arifin M, Muttaqin Z, Bakhtiar Y et al (2020) Seizure outcomes in patients with complete versus anterior corpus callosotomy: analysis of outcome. Int J Gen Med 13:105–110

    Article  PubMed  PubMed Central  Google Scholar 

  3. Sunaga S, Shimizu H, Sugano H (2009) Long-term follow-up of seizure outcomes after corpus callosotomy. Seizure 18(2):124–128

    Article  PubMed  Google Scholar 

  4. Graham D, Tisdall MM, Gill D (2016) Corpus callosotomy outcomes in pediatric patients: a systematic review. Epilepsia 57(7):1053–1068

    Article  PubMed  Google Scholar 

  5. Chan AY, Rolston JD, Lee B et al (2018) Rates and predictors of seizure outcome after corpus callosotomy for drug-resistant epilepsy: a meta-analysis. J Neurosurg 130(4):1193–1202

    Article  PubMed  PubMed Central  Google Scholar 

  6. Koh S, Uda T, Kunihiro N et al (2022) Disconnection surgery to cure or palliate medically intractable epileptic spasms: a retrospective study. J Neurosurg Pediatr 29(6):693–699

    Article  PubMed  Google Scholar 

  7. Baba H, Toda K, Ono T et al (2018) Surgical and developmental outcomes of corpus callosotomy for West syndrome in patients without MRI lesions. Epilepsia 59(12):2231–2239

    Article  PubMed  Google Scholar 

  8. Velagapudi L, Matias CM, Ambrose TM et al (2021) Alternate seizure spread with agenesis of the corpus callosum. J Epilepsy Res 11(1):100–105

    Article  PubMed  PubMed Central  Google Scholar 

  9. Jeong G-U, Kim H, Lim BC et al (2011) Predictive value of electroencephalography for seizure outcome following corpus callosotomy in children. J Epilepsy Res 1(2):65–70

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kanai S, Oguri M, Okanishi T et al (2019) Symmetry of ictal slow waves may predict the outcomes of corpus callosotomy for epileptic spasms. Sci Rep 9(1):19733

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Oguri M, Okanishi T, Kanai S, Baba S, Nishimura M, Ogo K, Himoto T, Okanari K, Maegaki Y, Enoki H, Fujimoto A (2020) Phase lag analyses on ictal scalp electroencephalography may predict outcomes of corpus callosotomy for epileptic spasms. Front Neurol 11:576087. https://doi.org/10.3389/fneur.2020.576087

  12. Okumura E, Iwasaki M, Sakuraba R et al (2013) Time-varying inter-hemispheric coherence during corpus callosotomy. Clin Neurophysiol 124(11):2091–2100

    Article  PubMed  Google Scholar 

  13. Srinivasan R, Winter WR, Ding J et al (2007) EEG and MEG coherence: measures of functional connectivity at distinct spatial scales of neocortical dynamics. J Neurosci Methods 166(1):41–52

    Article  PubMed  PubMed Central  Google Scholar 

  14. Greenblatt RE, Pflieger ME, Ossadtchi AE (2012) Connectivity measures applied to human brain electrophysiological data. J Neurosci Methods 207(1):1–16

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Bowyer SM (2016) Coherence a measure of the brain networks: past and present. Neuropsychiatric Electrophysiol 2(1):1

    Article  Google Scholar 

  16. Montplaisir J, Nielsen T, Côté J et al (1990) Interhemispheric EEG coherence before and after partial callosotomy. Clin Electroencephalogr 21(1):42–47

    Article  CAS  PubMed  Google Scholar 

  17. Matsuhashi A, Matsuo T, Kumada S (2022) Incremental changes in interhemispheric functional connectivity after two-stage corpus callosotomy in a patient with subcortical band heterotopia. Epilepsy Behav Rep 18:100525

    Article  PubMed  PubMed Central  Google Scholar 

  18. Oguni H, Olivier A, Andermann F et al (1991) Anterior callosotomy in the treatment of medically intractable epilepsies: a study of 43 patients with a mean follow-up of 39 months. Ann Neurol 30(3):357–364

    Article  CAS  PubMed  Google Scholar 

  19. Lee C-C, Hung S-C, Chen Y-H et al (2022) Structural connectivity in children after total corpus callosotomy. Epilepsy Res 182:106908

    Article  PubMed  Google Scholar 

  20. Johnston JM, Vaishnavi SN, Smyth MD et al (2008) Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum. J Neurosci 28(25):6453–6458

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Uddin LQ, Mooshagian E, Zaidel E et al (2008) Residual functional connectivity in the split-brain revealed with resting-state functional MRI. Neuroreport 19(7):703–709

    Article  PubMed  PubMed Central  Google Scholar 

  22. Pizoli CE, Shah MN, Snyder AZ et al (2011) Resting-state activity in development and maintenance of normal brain function. Proc Natl Acad Sci USA 108(28):11638–11643

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Roland JL, Snyder AZ, Hacker CD et al (2017) On the role of the corpus callosum in interhemispheric functional connectivity in humans. Proc Natl Acad Sci USA 114(50):13278–13283

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Liang J-G, Kim N-Y, Ko A et al (2018) Changes in functional brain network topology after successful and unsuccessful corpus callosotomy for lennox-gastaut syndrome. Sci Rep 8(1):3414

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

A draw figure was illustrated by Dr. Ariya Mongkolporn.

Funding

This work was supported by JSPS KAKENHI Grant Number JP22K09212.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan

    Vich Yindeedej, Takehiro Uda, Shugo Nishijima & Takeo Goto

  2. Department of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan

    Vich Yindeedej, Takehiro Uda, Noritsugu Kunihiro & Ryoko Umaba

  3. Division of Neurosurgery, Department of Surgery, Thammasat University Hospital, Faculty of Medicine, Thammasat University, Pathumthani, Thailand

    Vich Yindeedej

  4. Department of Pediatric Neurology, Osaka City General Hospital, Osaka, Japan

    Takeshi Inoue, Ichiro Kuki, Masataka Fukuoka, Megumi Nukui & Shin Okazaki

Authors
  1. Vich Yindeedej
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takehiro Uda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shugo Nishijima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takeshi Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ichiro Kuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masataka Fukuoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Megumi Nukui
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shin Okazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Noritsugu Kunihiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ryoko Umaba
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Takeo Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization and design: Yindeedej, Uda. Acquisition of data: Uda, Nishijima, Inoue, Kuki, Fukuoka, Nukui, Okazaki. Patient care: Inoue, Kuki, Fukuoka, Nukui, Okazaki, Kunihiro, Umaba. Analysis and interpretation of data: Yindeedej, Uda. Drafting of the manuscript: Yindeedej. Critical revision: Uda. Review of the submitted version of the manuscript: All authors. Approval of the final version: Uda. Study supervision: Goto.

Corresponding author

Correspondence to Takehiro Uda.

Ethics declarations

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of Osaka City General Hospital and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

The patient consented to the procedure and written informed consent was obtained.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yindeedej, V., Uda, T., Nishijima, S. et al. Changes in interhemispheric coherence after total corpus callosotomy: a scalp EEG study in children with non-lesional generalized epilepsy. Childs Nerv Syst (2024). https://doi.org/10.1007/s00381-024-06435-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00381-024-06435-3

Keywords

Search

Navigation