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Raine’s syndrome: rare disease from neurosurgical perspective

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Abstract

Raine’s syndrome (RS) is a rare genetic disorder. Only 25 cases are in literature. Occurs due to genetic mutation resulting in deranged bone metabolism. Few cases are reported discussing the neurosurgical ramifications of the disease. We report a child diagnosed with RS. He was presented with multisutural synostosis requiring craniofacial intervention with two vault expansions. Additionally, required VP shunt due to hydrocephalus. We consider our case unique among reports of RS, as our patient has survived for 10. He died due to valve obstruction of the VP shunt. We also present a review of relevant medical literature.

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Data availability

Data of the case is available under the regulations and rules of the document confidentiality of Alder Hey Children hospital NHS foundation trust.

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Funding

We declare that there was no funding obtained.

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Authors and Affiliations

  1. Neurosurgery Department, Alder Hey Children Hospital, Liverpool, UK

    Mostafa Elmaghraby, Sahibzada Abrar, Santosh Mohan Rao Kanangi, Christopher Parks, Christian Duncan, David Richardson & Ajay Sinha

  2. Neurosurgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

    Mostafa Elmaghraby

Authors
  1. Mostafa Elmaghraby
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  2. Sahibzada Abrar
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  3. Santosh Mohan Rao Kanangi
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  4. Christopher Parks
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  5. Christian Duncan
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  6. David Richardson
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  7. Ajay Sinha
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Contributions

Mostafa Elmaghraby: Prepared the data, wrote the paper. Sahibzada Abrar: Prepared the figures. Santosh Mohan Rao Kanangi: Collected data. Christopher Parks: Surgeon and revised the paper. Christian Duncan: Surgeon. David Richardson: Surgeon. Ajay Sinha: Surgeon and revised the paper.

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Correspondence to Mostafa Elmaghraby.

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Elmaghraby, M., Abrar, S., Kanangi, S.M.R. et al. Raine’s syndrome: rare disease from neurosurgical perspective. Childs Nerv Syst 40, 11–17 (2024). https://doi.org/10.1007/s00381-023-06174-x

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  • DOI: https://doi.org/10.1007/s00381-023-06174-x

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