Abstract
Background
Reaching a tumor within the third ventricle is challenging, and planning an accessible trajectory is crucial without injuring the surrounding structures.
Case summary
We report a 5-year-old boy presented with headache and a seizure where sequential MRI brain studies in a short time period revealed a rapid growing immature teratoma within the third ventricle with hydrocephalic changes. Several management procedures were performed for CSF diversion and medical treatment of the tumor with chemotherapy and stem cell therapy. The tumor was rapidly growing, and surgical excision was decided. Total resection was achieved via endoscope-assisted microsurgical transcallosal approach. Seven years after surgery, the patient experienced no recurrence of the tumor with a favorable clinical condition.
Conclusion
We report a rare case of posterior third ventricular immature teratoma where the endoscope-assisted microsurgical technique was implemented with favorable long-term postoperative outcome.
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References
Siwanuwatn R, Deshmukh P, Feiz-Erfan I et al (2005) Microsurgical anatomy of the transcallosal anterior interforniceal approach to the third ventricle. Neurosurgery 56:390–6
Kasowski HJ, Nahed BV, Piepmeier JM (2005) Transcallosal transchoroidal approach to tumors of the third ventricle. Neurosurgery 57:361–6
Fonseca A, Faure-Conter C, Murray MJ et al (2022) Pattern of treatment failures in patients with central nervous system non-germinomatous germ cell tumors (CNS-NGGCT): A pooled analysis of clinical trials. Neuro Oncol 24:1950–1961
Hu X, Ren Y-M, Yang X et al (2022) Surgical Treatment of pineal region tumors: 18 years experience at a Single Institution. World Neurosurg. https://doi.org/10.1016/j.wneu.2022.09.091
Kanamori M, Kumabe T, Tominaga T (2008) Is histological diagnosis necessary to start treatment for germ cell tumours in the pineal region? J Clin Neurosci 15:978–987
Cheng C-M, Chiang Y-H, Nieh S (2006) Pineal region teratoma with high serum and CSF alpha-fetoprotein levels. J Clin Neurosci 13:257–259
Goyal N, Kakkar A, Singh PK et al (2013) Intracranial teratomas in children: a clinicopathological study. Childs Nerv Syst 29:2035–2042
Tanrıkulu B, Özek MM (2020) Management of mature pineal region teratomas in pediatric age group. Childs Nerv Syst 36:153–163
Phi JH, Kim S-K, Park S-H et al (2005) Immature teratomas of the central nervous system: is adjuvant therapy mandatory? J Neurosurg 103:524–530
Ulm AJ, Russo A, Albanese E et al (2009) Limitations of the transcallosal transchoroidal approach to the third ventricle. J Neurosurg 111:600–609
Lozier AP, Bruce JN (2003) Surgical approaches to posterior third ventricular tumors. Neurosurg Clin N Am 14:527–545
Patel P, Cohen-Gadol AA, Boop F, Klimo P Jr (2014) Technical strategies for the transcallosal transforaminal approach to third ventricle tumors: expanding the operative corridor. J Neurosurg Pediatr 14:365–371
El Refaee EA, Baldauf J, Balau V et al (2013) Is it safe to sacrifice the superior hypophyseal artery in aneurysm clipping? A report of two cases. J Neurol Surg A Cent Eur Neurosurg 74(Suppl 1):e255–e260
El Refaee E, Langner S, Marx S et al (2019) Endoscope-Assisted Microvascular Decompression for the Management of Hemifacial Spasm Caused by Vertebrobasilar Dolichoectasia. World Neurosurg 121:e566–e575
El Refaee E, Fleck S, Matthes M et al (2021) Outcome of Endoscope-Assisted Microvascular Decompression in Patients With Hemifacial Spasm Caused by Severe Indentation of the Brain Stem at the Pontomedullary Sulcus by the Posterior Inferior Cerebellar Artery. Oper Neurosurg (Hagerstown) 20:E399–E405
Fleck S, Damaty AE, Lange I et al (2022) Pineal cysts without hydrocephalus: microsurgical resection via an infratentorial-supracerebellar approach-surgical strategies, complications, and their avoidance. Neurosurg Rev 45:3327–3337
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Conception and design: El Refaee. Revision of data: Fleck, Lode. Supervision, revision of the final manuscript: Schroeder. Technical assistance and artwork preparation: Matthes.
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Henry W. S. Schroeder is a consultant to Karl Starz GmbH, Tutlingen, Germany.
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Refaee, E.E., Fleck, S., Matthes, M. et al. Endoscope-assisted microsurgical resection of a third ventricular immature teratoma. Childs Nerv Syst 39, 3435–3443 (2023). https://doi.org/10.1007/s00381-023-06054-4
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DOI: https://doi.org/10.1007/s00381-023-06054-4