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Clinical presentation, natural history, and outcomes for infantile intracranial cavernous malformations: case series and systematic review of the literature

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Abstract

Introduction

Intracranial cavernous malformations (CMs) are rare vascular malformations of the central nervous system in children. Infantile patients, being a developmentally vulnerable age group, pose a special challenge for management of these lesions. We pooled data from infantile patients diagnosed at our institution and individual cases published in the literature to provide input towards therapeutic decision-making.

Methods

A systematic search of PubMed, MEDLINE, Embase, and Scopus was performed in accordance with PRISMA guidelines to identify all reported cases of intracranial CMs in the literature for infantile patients aged ≤ 2 years. In addition, cases from our institution diagnosed between 2010 and 2020 were also included. Individual cases were pooled and analyzed for clinical presentation, natural history, and outcomes from conservative and surgical management.

Results

A total of 36 cases were included, of which 32 were identified from the literature. Median age at presentation was 14 months (range: 2 days to 24 months) months; 53% (n = 19) were females. Most cavernomas (64%, 23/36) were supratentorial, while 30% (n = 11) were located in brainstem and 5.5% (n = 2) in the cerebellum. With the exception of one patient, all cases were reported to be symptomatic; seizures (n = 15/31, 48.3%) and motor deficits (n = 13/31, 42%) were the most common symptom modalities. A total of 13 patients were managed conservatively upon initial presentation. No symptomatic hemorrhages were observed during 26 total person-years of follow-up. A total of 77% (28/36) underwent surgery; either upfront (23/28, 82%) at initial presentation or following conservative management. Among 12 patients who had preoperative seizures, 11/12 (91.6%) achieved seizure freedom post-resection. Among 7 patients who presented with hemiparesis preoperatively, 5 (71%) demonstrated some improvement, while 1 remained unchanged, and another patient with a brainstem cavernous malformation had worsening of motor function postoperatively. Postoperative recurrence was noted in 3 cases (3/27, 11%).

Conclusion

Annual risk of repeat hemorrhage may be low for infantile patients with intracranial cavernous malformations; however, better follow-up rates and higher number of cases are needed to make a definitive assertion. Surgical resection may be associated with high rates of epilepsy cure and provide improvement in neurological function in a select number of cases.

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Authors and Affiliations

  1. Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, USA

    Anshit Goyal

  2. City University of New York School of Medicine, New York, NY, USA

    Jenelys Fernandes-Torres & David J. Daniels

  3. Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA

    Jenelys Fernandes-Torres

  4. Department of Neurology, Mayo Clinic, Rochester, MN, USA

    Kelly D. Flemming

  5. Department of Neurology, Mayo Clinic, Jacksonville, FL, USA

    Lindsy N. Williams

Authors
  1. Anshit Goyal
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  2. Jenelys Fernandes-Torres
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  3. Kelly D. Flemming
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  4. Lindsy N. Williams
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  5. David J. Daniels
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Contributions

Anshit Goyal collected and analyzed data and wrote the main manuscript text. Jenelys Fernandes-Torres collected data. Kelly Flemming and Lindsy Williams made revisions. David J Daniels made revisions and provided overall study supervision. All authors reviewed the final manuscript.

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Correspondence to David J. Daniels.

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Goyal, A., Fernandes-Torres, J., Flemming, K.D. et al. Clinical presentation, natural history, and outcomes for infantile intracranial cavernous malformations: case series and systematic review of the literature. Childs Nerv Syst 39, 1545–1554 (2023). https://doi.org/10.1007/s00381-023-05903-6

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  • DOI: https://doi.org/10.1007/s00381-023-05903-6

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