Skip to main content

Advertisement

SpringerLink
Log in

Treatment modalities of ALK-positive relapsed/refractory inflammatory myofibroblastic tumor of the brain and lungs in 7-year-old girl: case-based reviews

  • Case-based Review
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Purpose

Inflammatory myofibroblastic tumor (IMT) belongs to mesenchymal neoplasm of intermediate malignancy in WHO classification. Primary CNS disease or CNS metastases (CNS-IMT) occur in minority. We describe a case of relapsed/refractory IMT of lungs with multiple brain metastases in young child who achieved long-term complete response after alectinib. This systematic review also summarizes treatment modalities and outcome of children and adolescent with CNS-IMT.

Methods

PRISMA 2020 guideline was applied to select an article from PubMed, Scopus, and Cochrane databases without time limits. This review focused on children and adolescent 0–24 years of age with CNS-IMT or inflammatory pseudotumor (CNS-IPT). The clinical characteristics and treatment outcome were explored.

Results

A total of 51 patients in 49 publications were identified. Median age of patients with CNS-IMT/IPT was 15-year-old and 60.8% were male. The most common location of tumor was cerebral cortex (54.9%). Complete resection of CNS-IMT/IPT was performed in 27 cases with 100% complete response and 18.5% recurrence. Nearly half of patients who received partial resection without adjuvant therapy experienced progressive disease, while the contrast group totally achieved partial response. Overall responses in 7 patients treating with ALK inhibitors were 57.1% durable complete response and 42.9% transient partial response.

Conclusion

First-line treatment of CNS-IMT/IPT is complete resection. Patients who received partial tumor removal might have benefit from adjuvant therapy. ALK inhibitors reveal a promising result in unresectable CNS-IMT/IPT. Our case has shown a success in treating relapsed and refractory CNS-IMT as well as the primary site using 2nd-generation ALK inhibitor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

The original contributions presented in the study are included in the article/supplementary material.

Code availability

Not applicable.

References

  1. Choi JH, Ro JY (2021) The 2020 WHO classification of tumors of soft tissue: selected changes and new entities. Adv Anat Pathol 28(1):44–58. https://doi.org/10.1097/PAP.0000000000000284

    Article  PubMed  Google Scholar 

  2. Alaggio R, Cecchetto G, Bisogno G, Gambini C, Calabro ML, Inserra A, Boldrini R, De Salvo GL, GdA ES, Dall’igna P (2010) Inflammatory myofibroblastic tumors in childhood: a report from the Italian Cooperative Group studies. Cancer 116(1):216–226. https://doi.org/10.1002/cncr.24684

    Article  PubMed  Google Scholar 

  3. Chan YF, White J, Brash H (1994) Metachronous pulmonary and cerebral inflammatory pseudotumor in a child. Pediatr Pathol 14(5):805–815. https://doi.org/10.3109/15513819409037678

    Article  CAS  PubMed  Google Scholar 

  4. Casanova M, Brennan B, Alaggio R, Kelsey A, Orbach D, van Noesel MM, Corradini N, Minard-Colin V, Zanetti I, Bisogno G, Gallego S, Merks JHM, De Salvo GL, Ferrari A (2020) Inflammatory myofibroblastic tumor: the experience of the European pediatric Soft Tissue Sarcoma Study Group (EpSSG). Eur J Cancer 127:123–129. https://doi.org/10.1016/j.ejca.2019.12.021

    Article  CAS  PubMed  Google Scholar 

  5. Cook JR, Dehner LP, Collins MH, Ma Z, Morris SW, Coffin CM, Hill DA (2001) Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol 25(11):1364–1371. https://doi.org/10.1097/00000478-200111000-00003

    Article  CAS  PubMed  Google Scholar 

  6. Gaudichon J, Jeanne-Pasquier C, Deparis M, Veyssiere A, Heyndrickx M, Minckes O, Orbach D (2016) Complete and repeated response of a metastatic ALK-rearranged inflammatory myofibroblastic tumor to crizotinib in a teenage girl. J Pediatr Hematol Oncol 38(4):308–311. https://doi.org/10.1097/MPH.0000000000000498

    Article  PubMed  Google Scholar 

  7. Brivio E, Zwaan CM (2019) ALK inhibition in two emblematic cases of pediatric inflammatory myofibroblastic tumor: Efficacy and side effects. Pediatr Blood Cancer 66(5):e27645. https://doi.org/10.1002/pbc.27645

    Article  PubMed  Google Scholar 

  8. Mossé YP, Voss SD, Lim MS, Rolland D, Minard CG, Fox E, Adamson P, Wilner K, Blaney SM, Weigel BJ (2017) Targeting ALK with crizotinib in pediatric anaplastic large cell lymphoma and inflammatory myofibroblastic tumor: a Children’s Oncology Group Study. J Clin Oncol 35(28):3215–3221. https://doi.org/10.1200/jco.2017.73.4830

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Costa DB, Kobayashi S, Pandya SS, Yeo WL, Shen Z, Tan W, Wilner KD (2011) CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol 29(15):e443-445. https://doi.org/10.1200/JCO.2010.34.1313

    Article  PubMed  Google Scholar 

  10. Kodama T, Hasegawa M, Takanashi K, Sakurai Y, Kondoh O, Sakamoto H (2014) Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases. Cancer Chemother Pharmacol 74(5):1023–1028. https://doi.org/10.1007/s00280-014-2578-6

    Article  CAS  PubMed  Google Scholar 

  11. Craig E, Wiltsie LM, Beaupin LK, Baig A, Kozielski R, Rothstein DH, Li V, Twist CJ, Barth M (2021) Anaplastic lymphoma kinase inhibitor therapy in the treatment of inflammatory myofibroblastic tumors in pediatric patients: case reports and literature review. J Pediatr Surg 56(12):2364–2371. https://doi.org/10.1016/j.jpedsurg.2021.02.004

    Article  PubMed  Google Scholar 

  12. Vidrine DW, Berry JF, Garbuzov A, Falcon C, Tubbs RS, Bui CJ (2021) DCTN1-ALK gene fusion in inflammatory myofibroblastic tumor (IMT) of the CNS. Childs Nerv Syst 37(7):2147–2151. https://doi.org/10.1007/s00381-021-05219-3

    Article  PubMed  Google Scholar 

  13. Pire A, Orbach D, Galmiche L, Berrebi D, Irtan S, Boudjemaa S, Brisse HJ, Berteloot L, Moalla S, Mussini C, Philippe-Chomette P, Tilea B, Pierron G, Guerin F, Minard-Colin V, Sarnacki S (2022) Clinical, pathologic, and molecular features of inflammatory myofibroblastic tumors in children and adolescents. Pediatr Blood Cancer 69(5):e29460. https://doi.org/10.1002/pbc.29460

    Article  CAS  PubMed  Google Scholar 

  14. Fu GX, Xu CC, Yao NF, Gu JZ, Jiang HL, Han XF (2019) Inflammatory myofibroblastic tumor: a demographic, clinical and therapeutic study of 92 cases. Math Biosci Eng 16(6):6794–6804. https://doi.org/10.3934/mbe.2019339

    Article  PubMed  Google Scholar 

  15. Rich BS, Fishbein J, Lautz T, Rubalcava NS, Kartal T, Newman E, Wok PE, Romao RLP, Whitlock R, Naik-Mathuria B, Polites SF, Lofberg K, Lascano D, Kim E, Davidson J, Butter A, Kastenberg ZJ, Short SS, Meyers RL, Glick RD (2022) Inflammatory myofibroblastic tumor: A multi-institutional study from the Pediatric Surgical Oncology Research Collaborative. Int J Cancer 151(7):1059–1067. https://doi.org/10.1002/ijc.34132

    Article  CAS  PubMed  Google Scholar 

  16. Tang TT, Segura AD, Oechler HW, Harb JM, Adair SE, Gregg DC, Camitta BM, Franciosi RA (1990) Inflammatory myofibrohistiocytic proliferation simulating sarcoma in children. Cancer 65(7):1626–1634. https://doi.org/10.1002/1097-0142(19900401)65:7%3c1626::aid-cncr2820650729%3e3.0.co;2-v

    Article  CAS  PubMed  Google Scholar 

  17. Häusler M, Schaade L, Ramaekers VT, Doenges M, Heimann G, Sellhaus B (2003) Inflammatory pseudotumors of the central nervous system: report of 3 cases and a literature review. Hum Pathol 34(3):253–262. https://doi.org/10.1053/hupa.2003.35

    Article  PubMed  Google Scholar 

  18. Gleason BC, Hornick JL (2008) Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol 61(4):428–437. https://doi.org/10.1136/jcp.2007.049387

    Article  CAS  PubMed  Google Scholar 

  19. Sawyer SM, Azzopardi PS, Wickremarathne D, Patton GC (2018) The age of adolescence. Lancet Child Adolesc Health 2(3):223–228. https://doi.org/10.1016/S2352-4642(18)30022-1

    Article  PubMed  Google Scholar 

  20. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hrobjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

    Article  PubMed  PubMed Central  Google Scholar 

  21. Bencherif B, Zouaoui A, Chedid G, Kujas M, Van Effenterre R, Marsault C (1993) Intracranial extension of an idiopathic orbital inflammatory pseudotumor. Am J Neuroradiol 14(1):181–184

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Pimentel J, Costa A, Távora L (1993) Inflammatory pseudotumor of the choroid plexus. Case report J Neurosurg 79(6):939–942. https://doi.org/10.3171/jns.1993.79.6.0939

    Article  CAS  PubMed  Google Scholar 

  23. Tresser N, Rolf C, Cohen M (1996) Plasma cell granulomas of the brain: pediatric case presentation and review of the literature. Childs Nerv Syst 12(1):52–57. https://doi.org/10.1007/bf00573857

    Article  CAS  PubMed  Google Scholar 

  24. Gollogly L, Sadzot B, Lejeune JP, Deprez M (2001) Meningeal inflammatory pseudotumour: a case report. Acta Neurol Belg 101(2):116–120

    CAS  PubMed  Google Scholar 

  25. Bigal ME, Rapoport AM, Camel M (2003) Cluster headache as a manifestation of intracranial inflammatory myofibroblastic tumour: a case report with pathophysiological considerations. Cephalalgia 23(2):124–128. https://doi.org/10.1046/j.1468-2982.2003.00508.x

    Article  CAS  PubMed  Google Scholar 

  26. Jeon YK, Chang KH, Suh YL, Jung HW, Park SH (2005) Inflammatory myofibroblastic tumor of the central nervous system: clinicopathologic analysis of 10 cases. J Neuropathol Exp Neurol 64(3):254–259. https://doi.org/10.1093/jnen/64.3.254

    Article  PubMed  Google Scholar 

  27. Mergan F, Jaubert F, Sauvat F, Hartmann O, Lortat-Jacob S, Révillon Y, Nihoul-Fékété C, Sarnacki S (2005) Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus 8 detection analysis. J Pediatr Surg 40(10):1581–1586. https://doi.org/10.1016/j.jpedsurg.2005.06.021

    Article  PubMed  Google Scholar 

  28. Jeba J, John S, Backiyanathan S, Christopher DJ, Kurian S (2008) Inflammatory pseudotumour of the lung with sarcomatous brain metastasis. Eur J Cancer Care (Engl) 17(4):412–414. https://doi.org/10.1111/j.1365-2354.2007.00886.x

    Article  CAS  PubMed  Google Scholar 

  29. Suri V, Shukla B, Garg A, Singh M, Rishi A, Sharma MC, Sarkar C (2008) Intracranial inflammatory pseudotumor: report of a rare case. Neuropathology 28(4):444–447. https://doi.org/10.1111/j.1440-1789.2008.00870.x

    Article  PubMed  Google Scholar 

  30. Swain RS, Tihan T, Horvai AE, Di Vizio D, Loda M, Burger PC, Scheithauer BW, Kim GE (2008) Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor. Hum Pathol 39(3):410–419. https://doi.org/10.1016/j.humpath.2007.07.012

    Article  CAS  PubMed  Google Scholar 

  31. de Oliveira RS, Amato MC, Brassesco MS, Valera ET, Jucá CE, Neder L, Tone LG, Machado HR (2009) Clinical and cytogenetic analysis of an intracranial inflammatory myofibroblastic tumor induced by a ventriculoperitoneal shunt. J Neurosurg Pediatr 4(4):372–377. https://doi.org/10.3171/2009.5.Peds0958

    Article  PubMed  Google Scholar 

  32. Fabre D, Fadel E, Singhal S, de Montpreville V, Mussot S, Mercier O, Chataigner O, Dartevelle PG (2009) Complete resection of pulmonary inflammatory pseudotumors has excellent long-term prognosis. J Thorac Cardiovasc Surg 137(2):435–440. https://doi.org/10.1016/j.jtcvs.2008.07.009

    Article  PubMed  Google Scholar 

  33. Choi BD, Hodges TR, Grant GA, Fuchs HE, Cummings TJ, Muh CR (2012) Inflammatory pseudotumor of the lateral ventricle in a pediatric patient. Pediatr Neurosurg 48(6):374–378. https://doi.org/10.1159/000353609

    Article  PubMed  Google Scholar 

  34. Ohue S, Kohno S, Matsui S, Kumon Y, Ohnishi T (2012) Inflammatory pseudotumor in the lateral ventricle. Case report Neurol Med Chir (Tokyo) 52(8):599–602. https://doi.org/10.2176/nmc.52.599

    Article  PubMed  Google Scholar 

  35. Siminovich M, Galluzzo L, López J, Lubieniecki F, de Dávila MT (2012) Inflammatory myofibroblastic tumor of the lung in children: anaplastic lymphoma kinase (ALK) expression and clinico-pathological correlation. Pediatr Dev Pathol 15(3):179–186. https://doi.org/10.2350/11-10-1105-oa.1

    Article  PubMed  Google Scholar 

  36. Alyono JC, Shi Y, Berry GJ, Recht LD, Harsh GRt, Jackler RK, Corrales CE, (2015) Inflammatory pseudotumors of the skull base: meta-analysis. Otol Neurotol 36(8):1432–1438. https://doi.org/10.1097/mao.0000000000000818

    Article  PubMed  Google Scholar 

  37. Chuah YY, Tashi T, Shy CG, Shyu JS, Dong MJ, Hsueh EJ (2016) Intracranial Inflammatory myofibroblastic tumor with sarcomatous local recurrence. World Neurosurg 93:484.e481-484. https://doi.org/10.1016/j.wneu.2016.07.060

    Article  Google Scholar 

  38. Singhal N, Agarwal V, Chawla A, Tangri R (2017) Central nervous system inflammatory myofibroblastic tumor masquerading as chronic suppurative otitis media. J Pediatr Neurosci 12(2):188–191. https://doi.org/10.4103/jpn.JPN_95_16

    Article  PubMed  PubMed Central  Google Scholar 

  39. Bhujabal SN, Chandra Nath P, Behera R, Swarnakar PK, Dhir MK, Mishra S (2018) Spinal Epidural inflammatory pseudotumor: a case report and review of literature. World Neurosurg 117:225–228. https://doi.org/10.1016/j.wneu.2018.06.079

    Article  PubMed  Google Scholar 

  40. Inoue M, Ohta T, Shioya H, Sato S, Takahashi H, Nakata N, Taniguchi C, Hirano M, Nishioka M, Yamakawa H (2018) Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial, lung, and pancreas involvement: ultrasonographic findings and a review of the literature. J Med Ultrason (2001)45(2):331–335. https://doi.org/10.1007/s10396-017-0829-y

    Article  Google Scholar 

  41. Kube S, Vokuhl C, Dantonello T, Scheer M, Hallmen E, Feuchtgruber S, Escherich G, Niggli F, Kuehnle I, von Kalle T, Bielack S, Klingebiel T, Koscielniak E (2018) Inflammatory myofibroblastic tumors-a retrospective analysis of the Cooperative Weichteilsarkom Studiengruppe. Pediatr Blood Cancer 65(6):e27012. https://doi.org/10.1002/pbc.27012

    Article  CAS  PubMed  Google Scholar 

  42. Lata KA, Upadhyay V, Pawar SS (2018) A rare case of inflammatory myofibroblastic tumor of meninges. J Pediatr Neurosci 13(2):255–259. https://doi.org/10.4103/jpn.JPN_117_17

    Article  PubMed  PubMed Central  Google Scholar 

  43. Maruggi M, Malicki DM, Levy ML, Crawford JR (2018) A novel KIF5B-ALK fusion in a child with an atypical central nervous system inflammatory myofibroblastic tumour. BMJ Case Rep. https://doi.org/10.1136/bcr-2018-226431

    Article  PubMed  PubMed Central  Google Scholar 

  44. Wang X, Chen Y, Wu X, Zhang H (2019) Intracranial Inflammatory myofibroblastic tumor with negative expression of anaplastic lymphoma kinase: a case report and review of the literature. World Neurosurg 125:117–122. https://doi.org/10.1016/j.wneu.2019.01.155

    Article  PubMed  Google Scholar 

  45. Kaneva K, Wadhwani N, DiPatri AJ Jr, Palasis S, Goldman S, Aw-Zoretic J (2021) Benign skull and subdural lesions in patients with prior medulloblastoma therapy. Childs Nerv Syst 37(2):359–366. https://doi.org/10.1007/s00381-020-04874-2

    Article  PubMed  Google Scholar 

  46. Despeyroux-Ewers M, Catalaâ I, Collin L, Cognard C, Loubes-Lacroix F, Manelfe C (2003) Inflammatory myofibroblastic tumour of the spinal cord: case report and review of the literature. Neuroradiology 45(11):812–817. https://doi.org/10.1007/s00234-003-1069-y

    Article  CAS  PubMed  Google Scholar 

  47. Lacoste-Collin L, Roux FE, Gomez-Brouchet A, Despeyroux ML, Uro-Coste E, Coindre JM, Delisle MB (2003) Inflammatory myofibroblastic tumor: a spinal case with aggressive clinical course and ALK overexpression. Case report J Neurosurg 98(2):218–221. https://doi.org/10.3171/spi.2003.98.2.0218

    Article  PubMed  Google Scholar 

  48. Gale N, Zidar N, Podboj J, Volavsek M, Luzar B (2003) Inflammatory myofibroblastic tumour of paranasal sinuses with fatal outcome: reactive lesion or tumour? J Clin Pathol 56(9):715–717. https://doi.org/10.1136/jcp.56.9.715

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Radi-Bencteux S, Proust F, Vannier JP, Marret S, Laquerrière A (2003) Intracerebral inflammatory pseudotumour in a 16-month-old boy. Neuropediatrics 34(6):330–333. https://doi.org/10.1055/s-2003-44673

    Article  CAS  PubMed  Google Scholar 

  50. Chun YS, Wang L, Nascimento AG, Moir CR, Rodeberg DA (2005) Pediatric inflammatory myofibroblastic tumor: anaplastic lymphoma kinase (ALK) expression and prognosis. Pediatr Blood Cancer 45(6):796–801. https://doi.org/10.1002/pbc.20294

    Article  PubMed  Google Scholar 

  51. Kasliwal MK, Suri A, Gupta DK, Suri V, Rishi A, Sharma BS (2008) Sphenoid wing inflammatory pseudotumor mimicking a clinoidal meningioma: case report and review of the literature. Surg Neurol 70(5):509–513. https://doi.org/10.1016/j.surneu.2007.07.075

    Article  PubMed  Google Scholar 

  52. Kim JH, Chang KH, Na DG, Park SH, Kim E, Han DH, Kwon HM, Sohn CH, Yim YJ (2009) Imaging features of meningeal inflammatory myofibroblastic tumor. Am J Neuroradiol 30(6):1261–1267. https://doi.org/10.3174/ajnr.A1526

    Article  PubMed  PubMed Central  Google Scholar 

  53. Yuan C, Ma MJ, Parker JV, Mekhail TM (2017) Metastatic anaplastic lymphoma kinase-1 (ALK-1)-rearranged inflammatory myofibroblastic sarcoma to the brain with leptomeningeal involvement: favorable response to serial ALK inhibitors: a case report. Am J Case Rep 18:799–804. https://doi.org/10.12659/ajcr.903698

  54. Parker BM, Parker JV, Lymperopoulos A, Konda V (2019) A case report: pharmacology and resistance patterns of three generations of ALK inhibitors in metastatic inflammatory myofibroblastic sarcoma. J Oncol Pharm Pract 25(5):1226–1230. https://doi.org/10.1177/1078155218781944

    Article  CAS  PubMed  Google Scholar 

  55. Crespo C, Navarro M, Gonzalez I, Lorente MF, Gonzalez R, Mayol MJ (2001) Intracranial and mediastinal inflammatory myofibroblastic tumour. Pediatr Radiol 31(8):600–602. https://doi.org/10.1007/s002470100489

    Article  CAS  PubMed  Google Scholar 

  56. Trojan A, Stallmach T, Kollias S, Pestalozzi BC (2001) Inflammatory myofibroblastic tumor with CNS involvement. Onkologie 24(4):368–372. https://doi.org/10.1159/000055109

    Article  CAS  PubMed  Google Scholar 

  57. Klein AM, Schoem SR, Altman A, Eisenfeld L (2003) Inflammatory myofibroblastic tumor in the neonate: a case report. Otolaryngol Head Neck Surg 128(1):145–147. https://doi.org/10.1067/mhn.2003.45

    Article  PubMed  Google Scholar 

  58. Sharma S, Sankhyan N, Kalra V, Garg A, Gupta SD, Agarwala S, Das P (2009) Inflammatory myofibroblastic tumor involving lung and brain in a 10-year-old boy: a case report. J Child Neurol 24(10):1302–1306. https://doi.org/10.1177/0883073809341270

    Article  PubMed  Google Scholar 

  59. Jehangir M, Jang A, Ur Rehman I, Mamoon N (2017) Synchronous inflammatory myofibroblastic tumor in lung and brain: a case report and review of literature. Cureus 9(4):e1183. https://doi.org/10.7759/cureus.1183

    Article  PubMed  PubMed Central  Google Scholar 

  60. Carcamo B, Bista R, Wilson H, Reddy P, Pacheco J (2021) Rapid Response to lorlatinib in a patient with TFG-ROS1 fusion positive inflammatory myofibroblastic tumor of the chest wall metastatic to the brain and refractory to first and second generation ROS1 inhibitors. J Pediatr Hematol Oncol 43(5):e718–e722. https://doi.org/10.1097/mph.0000000000002185

    Article  CAS  PubMed  Google Scholar 

  61. Fukano R, Mori T, Sekimizu M, Choi I, Kada A, Saito AM, Asada R, Takeuchi K, Terauchi T, Tateishi U, Horibe K, Nagai H (2020) Alectinib for relapsed or refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma: An open-label phase II trial. Cancer Sci 111(12):4540–4547. https://doi.org/10.1111/cas.14671

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Siemion K, Reszec-Gielazyn J, Kisluk J, Roszkowiak L, Zak J, Korzynska A (2022) What do we know about inflammatory myofibroblastic tumors? - A systematic review. Adv Med Sci 67(1):129–138. https://doi.org/10.1016/j.advms.2022.02.002

    Article  CAS  PubMed  Google Scholar 

  63. Coffin CM, Watterson J, Priest JR, Dehner LP (1995) Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19(8):859–872. https://doi.org/10.1097/00000478-199508000-00001

  64. Cessna MH, Zhou H, Sanger WG, Perkins SL, Tripp S, Pickering D, Daines C, Coffin CM (2002) Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol 15(9):931–938. https://doi.org/10.1097/01.MP.0000026615.04130.1F

    Article  PubMed  Google Scholar 

  65. Da M, Qian B, Mo X, Xu C, Wu H, Jiang B, Peng W, Qi J, Sun J, Wu K (2021) Inflammatory myofibroblastic tumors in children: a clinical retrospective study on 19 cases. Front Pediatr 9:543078. https://doi.org/10.3389/fped.2021.543078

    Article  PubMed  PubMed Central  Google Scholar 

  66. Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG (2006) Inflammatory myofibroblastic tumors. J Surg Oncol 94(5):385–391. https://doi.org/10.1002/jso.20516

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank all clinicians providing care and management to this patient.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Chiang Mai University, Chiang Mai, Thailand

    Supapitch Chanthong, Lalita Sathitsamitphong, Rungrote Natesirinilkul, Pimlak Charoenkwan & Chane Choed-Amphai

  2. Department of Pathology, Chiang Mai University, Chiang Mai, Thailand

    Songkiet Suwansirikul

Authors
  1. Supapitch Chanthong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lalita Sathitsamitphong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rungrote Natesirinilkul
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pimlak Charoenkwan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Songkiet Suwansirikul
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chane Choed-Amphai
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

SC drafted the manuscript. All authors participated in patient management and data collection. SC and CC contributed to the systematic review. SS, SC, and CC prepared the figures. All authors contributed to the article and approved the submitted version.

Corresponding author

Correspondence to Chane Choed-Amphai.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethics statement

This case report and review literatures were approved by the Medical Ethics Committee of Faculty of Medicine, Chiang Mai University.

Consent for publication

Consent obtained and available.

Consent to participate

Not applicable.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chanthong, S., Sathitsamitphong, L., Natesirinilkul, R. et al. Treatment modalities of ALK-positive relapsed/refractory inflammatory myofibroblastic tumor of the brain and lungs in 7-year-old girl: case-based reviews. Childs Nerv Syst 39, 331–342 (2023). https://doi.org/10.1007/s00381-022-05789-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-022-05789-w

Keywords

Search

Navigation