Skip to main content

Advertisement

Log in

Surgical indications in pediatric arachnoid cysts

  • Review
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Introduction

Arachnoid cysts are developmental lesions consisting of CSF collections within the subarachnoid space. There are many theories and hypotheses about their pathogenesis and histopathology and this may also explain the diversities seen in clinical behaviors of these cysts, their natural history and consequently their management where there is a great controversy about selecting patients for surgical intervention. The most common location in pediatrics is the Sylvian or middle cranial fossa and this made it gain more concern and greater debate about its management where its diagnosis is often accidently or associated with nonspecific symptoms.

Aim

Our aim in this article was to review the main surgical indications for pediatric arachnoid cysts in the literature.

Conclusion

We concluded that the decision for surgical intervention for pediatric arachnoid cysts is not a simple one and highly debatable and should be taken cautiously especially with sylvian arachnoid cysts that may reach a large size without symptoms. However, there is a consensus that the occurrence of symptoms definitely correlated to the presence of these cysts or their rupture with consequent subdural hematoma or hygroma are indications for surgical intervention. Large cysts in locations compressing CSF pathways causing hydrocephalus are also candidates for surgical fenestration. The surgical gain from prophylactic surgery is questionable particularly when asymptomatic.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Availability of data and material

Not applicable.

References

  1. Rengachary SS, Watanabe I (1981) Ultrastructure and pathogenesis of intracranial arachnoid cysts. J Neuropathol Exp Neurol 40(1):61–83

    Article  CAS  PubMed  Google Scholar 

  2. Rengachary SS, Watanabe I, Brackett C (1978) Pathogenesis of intracranial arachnoid cysts. Surg Neurol 9(2):139–144

    CAS  PubMed  Google Scholar 

  3. Choi JU, Kim DS (1998) Pathogenesis of arachnoid cyst: congenital or traumatic? Pediatr Neurosurg 29(5):260–266

    Article  CAS  PubMed  Google Scholar 

  4. Contreras C, Copty M, Langelier R, Gagne F (1977) Traumatic suprasellar arachnoid cyst. Surg Neurol 8(3):196–198

    CAS  PubMed  Google Scholar 

  5. Aarhus M, Helland CA, Lund-Johansen M, Wester K, Knappskog PM (2010) Microarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cysts. Cerebrospinal fluid research 7(1):1–8

    Article  Google Scholar 

  6. Arriola G, de Castro P, Verdú A (2005) Familial arachnoid cysts. Pediatr Neurol 33(2):146–148

    Article  PubMed  Google Scholar 

  7. Helland CA, Wester K (2007) Monozygotic twins with mirror image cysts: indication of a genetic mechanism in arachnoid cysts? Neurology 69(1):110–111

    Article  PubMed  Google Scholar 

  8. Bayrakli F, Okten AI, Kartal U, Menekse G, Guzel A, Oztoprak I, Kars HZ (2012) Intracranial arachnoid cyst family with autosomal recessive trait mapped to chromosome 6q22. 31–23.2. Acta neurochirurgica 154(7):1287–1292

  9. Halani SH, Safain MG, Heilman CB (2013) Arachnoid cyst slit valves: the mechanism for arachnoid cyst enlargement: report of 5 cases. J Neurosurg Pediatr 12(1):62–66

    Article  PubMed  Google Scholar 

  10. Helland CA, Aarhus M, Knappskog P, Olsson LK, Lund-Johansen M, Amiry-Moghaddam M, Wester K (2010) Increased NKCC1 expression in arachnoid cysts supports secretory basis for cyst formation. Exp Neurol 224(2):424–428

    Article  CAS  PubMed  Google Scholar 

  11. Sandberg DI, McComb JG, Krieger MD (2005) Chemical analysis of fluid obtained from intracranial arachnoid cysts in pediatric patients. J Neurosurg Pediatr 103(5):427–432

    Article  Google Scholar 

  12. Rabiei K, Tisell M, Wikkelsø C, Johansson BR (2014) Diverse arachnoid cyst morphology indicates different pathophysiological origins. Fluids and Barriers of the CNS 11(1):1–11

    Article  Google Scholar 

  13. Go KG, Houthoff HJ, Blaauw EH, Havinga P, Hartsuiker J (1984) Arachnoid cysts of the sylvian fissure: evidence of fluid secretion. J Neurosurg 60(4):803–813

    Article  CAS  PubMed  Google Scholar 

  14. Schuhmann MU, Tatagiba M, Hader C, Brandis A, Samii M (2000) Ectopic choroid plexus within a juvenile arachnoid cyst of the cerebellopontine angle: cause of cyst formation or reason of cyst growth. Pediatr Neurosurg 32(2):73–76

    Article  CAS  PubMed  Google Scholar 

  15. Miyagami M, Kasahara E, Miyazaki S, Tsubokawa T, Kagawa Y (1991) Ultrastructural findings of arachnoid cysts and epithelial cysts. No to Shinkei= Brain and Nerve 43(6):545–553

  16. Tandon PN, Roy S, Elvidge A (1972) Subarachnoid ependymal cyst: report of two cases. J Neurosurg 37(6):741–745

    Article  CAS  PubMed  Google Scholar 

  17. Berle M, Kroksveen A, Garberg H, Aarhus M, Haaland Ø, Wester K, Berven F (2013) Quantitative proteomics comparison of arachnoid cyst fluid and cerebrospinal fluid collected perioperatively from arachnoid cyst patients. Fluids and Barriers of the CNS 10(1):1–10

    Article  Google Scholar 

  18. Di Rocco C (2010) Sylvian fissure arachnoid cysts: we do operate on them but should it be done? Childs Nerv Syst 26(2):173–175

    Article  PubMed  Google Scholar 

  19. Gosalakkal JA (2002) Intracranial arachnoid cysts in children: a review of pathogenesis, clinical features, and management. Pediatr Neurol 26(2):93–98

    Article  PubMed  Google Scholar 

  20. Amelot A, Beccaria K, Blauwblomme T, Bourgeois M, Paternoster G, Cuny ML, Puget S (2019) Microsurgical, endoscopic, and shunt management of pediatric temporosylvian arachnoid cysts: a comparative study. J Neurosurg Pediatr 23(6):749–757

    Article  PubMed  Google Scholar 

  21. Zhu GT, Li CZ, Gui SB, Zhao P, Li ZY, Liu CH, Zhang YZ (2022) Endoscopic fenestration for treating galassi type III middle cranial fossa arachnoid cysts: single-and multiple-stoma have the same curative effect. Journal of Neurological Surgery Part A: Central European Neurosurgery

  22. Tamburrini G, Del Fabbro M, Di Rocco C (2008) Sylvian fissure arachnoid cysts: a survey on their diagnostic workout and practical management. Child’s Nervous System 24(5):593–604

    Article  PubMed  Google Scholar 

  23. Rocco CD, Novegno F, Trevisi G (2014) The “complex” management of Sylvian fissure arachnoid cysts. In Neuroendoscopy (pp. 175–183). Springer, Berlin, Heidelberg

  24. Galassi E, Tognetti F, Gaist G, Fagioli L, Frank F, Frank G (1982) CT scan and metrizamide CT cisternography in arachnoid cysts of the middle cranial fossa: classification and pathophysiological aspects. Surg Neurol 17(5):363–369

    Article  CAS  PubMed  Google Scholar 

  25. Pradilla G, Jallo G (2007) Arachnoid cysts: case series and review of the literature. Neurosurg Focus 22(2):1–4

    Article  Google Scholar 

  26. Cincu R, Agrawal A, Eiras J (2007) Intracranial arachnoid cysts: current concepts and treatment alternatives. Clin Neurol Neurosurg 109(10):837–843

    Article  PubMed  Google Scholar 

  27. Ali M, Bennardo M, Almenawer SA, Zagzoog N, Smith AA, Dao D, Singh SK (2015) Exploring predictors of surgery and comparing operative treatment approaches for pediatric intracranial arachnoid cysts: a case series of 83 patients. J Neurosurg Pediatr 16(3):275–282

    Article  PubMed  Google Scholar 

  28. Al-Holou WN, Terman S, Kilburg C, Garton HJ, Muraszko KM, Maher CO (2013) Prevalence and natural history of arachnoid cysts in adults. J Neurosurg 118(2):222–231

    Article  PubMed  Google Scholar 

  29. Wester K (1999) Peculiarities of intracranial arachnoid cysts: location, sidedness, and sex distribution in 126 consecutive patients. Neurosurgery 45(4):775–779

    Article  CAS  PubMed  Google Scholar 

  30. Choi JW, Lee JY, Phi JH, Kim SK, Wang KC (2015) Stricter indications are recommended for fenestration surgery in intracranial arachnoid cysts of children. Childs Nerv Syst 31(1):77–86

    Article  PubMed  Google Scholar 

  31. Marin-Sanabria EA, Yamamoto H, Nagashima T, Kohmura E (2007) Evaluation of the management of arachnoid cyst of the posterior fossa in pediatric population: experience over 27 years. Childs Nerv Syst 23(5):535–542

    Article  PubMed  Google Scholar 

  32. Karabagli H, Etus V (2012) Success of pure neuroendoscopic technique in the treatment of Sylvian arachnoid cysts in children. Childs Nerv Syst 28(3):445–452

    Article  PubMed  Google Scholar 

  33. Spacca B, Kandasamy J, Mallucci CL, Genitori L (2010) Endoscopic treatment of middle fossa arachnoid cysts: a series of 40 patients treated endoscopically in two centres. Childs Nerv Syst 26(2):163–172

    Article  PubMed  Google Scholar 

  34. Fewel ME, Levy ML, McComb G (1996) Surgical treatment of 95 children with 102 intracranial arachnoid cysts. Pediatr Neurosurg 25(4):165–173

    Article  CAS  PubMed  Google Scholar 

  35. Oertel JM, Wagner W, Mondorf Y, Baldauf J, Schroeder HW, Gaab MR (2010) Endoscopic treatment of arachnoid cysts: a detailed account of surgical techniques and results. Neurosurgery 67(3):824–836

    Article  PubMed  Google Scholar 

  36. Talamonti G, D’Aliberti G, Picano M, Debernardi A, Collice M (2011) Intracranial cysts containing cerebrospinal fluid-like fluid: results of endoscopic neurosurgery in a series of 64 consecutive cases. Neurosurgery 68(3):788–803

    Article  PubMed  Google Scholar 

  37. Tamburrini G, Caldarelli M, Massimi L, Santini P, Di Rocco C (2003) Subdural hygroma: an unwanted result of Sylvian arachnoid cyst marsupialization. Childs Nerv Syst 19(3):159–165

    Article  CAS  PubMed  Google Scholar 

  38. Di Rocco F, James RS, Roujeau T, Puget S, Sainte-Rose C, Zerah M (2010) Limits of endoscopic treatment of sylvian arachnoid cysts in children. Childs Nerv Syst 26(2):155–162

    Article  PubMed  Google Scholar 

  39. Cinalli G, Spennato P, Ruggiero C, Aliberti F, Trischitta V, Buonocore MC, Maggi G (2007) Complications following endoscopic intracranial procedures in children. Childs Nerv Syst 23(6):633–644

    Article  PubMed  Google Scholar 

  40. Levy ML, Wang M, Aryan HE, Yoo K, Meltzer H (2003) Microsurgical keyhole approach for middle fossa arachnoid cyst fenestration. Neurosurgery 53(5):1138–1145

    Article  PubMed  Google Scholar 

  41. Ali ZS, Lang SS, Bakar D, Storm PB, Stein SC (2014) Pediatric intracranial arachnoid cysts: comparative effectiveness of surgical treatment options. Childs Nerv Syst 30(3):461–469

    Article  PubMed  Google Scholar 

  42. Chan JL, Tan AL, Ng LP, Low DC, Tew SW, Low SY (2021) Paediatric arachnoid cysts: surgical outcomes from a Singapore children’s hospital. J Clin Neurosci 85:122–131

    Article  PubMed  Google Scholar 

  43. Cinalli G, Spennato P, Columbano L, Ruggiero C, Aliberti F, Trischitta V, Cianciulli E (2010) Neuroendoscopic treatment of arachnoid cysts of the quadrigeminal cistern: a series of 14 cases. J Neurosurg Pediatr 6(5):489–497

    Article  PubMed  Google Scholar 

  44. Hagebeuk EE, Kloet A, Grotenhuis JA, Peeters EA (2005) Bobble-head doll syndrome successfully treated with an endoscopic ventriculocystocisternostomy: case report and review of the literature. J Neurosurg Pediatr 103(3):253–259

    Article  Google Scholar 

  45. Gui SB, Wang XS, Zong XY, Zhang YZ, Li CZ (2011) Suprasellar cysts: clinical presentation, surgical indications, and optimal surgical treatment. BMC Neurol 11(1):1–9

    Article  Google Scholar 

  46. Crimmins DW, Pierre-Kahn A, Sainte-Rose C, Zerah M (2006) Treatment of suprasellar cysts and patient outcome. J Neurosurg Pediatr 105(2):107–114

    Article  Google Scholar 

  47. Helland CA, Wester K (2007) Intracystic pressure in patients with temporal arachnoid cysts: a prospective study of preoperative complaints and postoperative outcome. J Neurol Neurosurg Psychiatry 78(6):620–623

    Article  PubMed  Google Scholar 

  48. Sgouros S, Chapman S (2001) Congenital middle fossa arachnoid cysts may cause global brain ischaemia: a study with 99Tc-hexamethylpropyleneamineoxime single photon emission computerised tomography scans. Pediatr Neurosurg 35(4):188–194

    Article  CAS  PubMed  Google Scholar 

  49. Tamburrini G (2018) Controversies in the management of intracranial arachnoid cysts. In Arachnoid Cysts (pp. 93–104). Academic Press

  50. Kim KH, Lee JY, Phi JH, Kim SK, Cho BK, Wang KC (2020) Long-term outcome of large sylvian arachnoid cysts: the role of surgery has been exaggerated. J Neurosurg Pediatr 26(3):221–227

    Article  PubMed  Google Scholar 

  51. Balestrino A, Piatelli G, Consales A, Cama A, Rossi A, Pacetti M, Pavanello M (2020) Spontaneous rupture of middle fossa arachnoid cysts: surgical series from a single center pediatric hospital and literature review. Childs Nerv Syst 36(11):2789–2799

    Article  PubMed  Google Scholar 

  52. Iaconetta G, Esposito M, Maiuri F, Cappabianca P (2006) Arachnoid cyst with intracystic haemorrhage and subdural haematoma: case report and literature review. Neurol Sci 26(6):451–455

    Article  CAS  PubMed  Google Scholar 

  53. Shrestha R, You C (2014) Spontaneous chronic subdural hematoma associated with arachnoid cyst in children and young adults. Asian journal of neurosurgery 9(3):168

    Article  PubMed  PubMed Central  Google Scholar 

  54. Hong JC, Kim MS, Chang CH, Kim SH (2008) Arachnoid cyst with spontaneous intracystic hemorrhage and chronic subdural hematoma. Journal of Korean Neurosurgical Society 43(1):54

    Article  PubMed  PubMed Central  Google Scholar 

  55. Huang D, Abe T, Kojima K, Tanaka N, Watauabe M, Ohkura A, Norbash AM (1999) Intracystic hemorrhage of the middle fossa arachnoid cyst and subdural hematoma caused by ruptured middle cerebral artery aneurysm. Am J Neuroradiol 20(7):1284–1286

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Parsch CS, Krauss J, Hofmann E, Meixensberger J, Roosen K (1997) Arachnoid cysts associated with subdural hematomas and hygromas: analysis of 16 cases, long-term follow-up, and review of the literature. Neurosurgery 40:483–490

    CAS  PubMed  Google Scholar 

  57. Oka Y, Kumon Y, Ohta S, Sakaki S, Ohue S, Takeda S (1994) Chronic subdural hematoma associated with middle fossa arachnoid cysts: three case reports. Neurol Med Chir (Tokyo) 34:95–99

    Article  CAS  PubMed  Google Scholar 

  58. Adin ME, Yıldız MS, Deniz MA, Behzadi AH, Mata-Mbemba D (2018) Arachnoid cysts with spontaneous intracystic hemorrhage and associated subdural hematoma: report of management and follow-up of 2 cases. Radiol Case Reports 13:516–521

    Article  Google Scholar 

  59. Lohani S, Robertson RL, Proctor MR (2013) Ruptured temporal lobe arachnoid cyst presenting with severe back pain. J Neurosurg Pediatr 12:281–283

    Article  PubMed  Google Scholar 

  60. Bora A, Yokuş A, Batur A, Bulut MD, Yavuz A, Gülşen İ, Özgökçe M, Arslan M (2015) Spontaneous rupture of the middle fossa arachnoid cyst into the subdural space: case report. Polish J Radiol 80:324–327

    Article  Google Scholar 

  61. Cress M, Kestle JR, Holubkov R, Riva-Cambrin J (2013) Risk factors for pediatric arachnoid cyst rupture/hemorrhage: a case-control study. Neurosurgery 72(5):716–722

    Article  PubMed  Google Scholar 

  62. Hall S, Smedley A, Sparrow O, Mathad N, Waters R, Chakraborty A, Tsitouras V (2019) Natural history of intracranial arachnoid cysts. World neurosurgery 126:e1315–e1320

    Article  PubMed  Google Scholar 

  63. Rao G, Anderson RC, Feldstein NA, Brockmeyer DL (2005) Expansion of arachnoid cysts in children: report of two cases and review of the literature. J Neurosurg Pediatr 102(3):314–317

    Article  Google Scholar 

  64. Lee JY, Kim JW, Phi JH, Kim SK, Cho BK, Wang KC (2012) Enlarging arachnoid cyst: a false alarm for infants. Childs Nerv Syst 28(8):1203–1211

    Article  PubMed  Google Scholar 

  65. Cokluk C, Senel A, Celik F, Ergur H (2003) Spontaneous disappearance of two asymptomatic arachnoid cysts in two different locations. Minim Invasive Neurosurg 46(2):110–112

    Article  CAS  PubMed  Google Scholar 

  66. Pandey P, Tripathi M, Chandra PS, Singh VP, Mehta VS (2001) Spontaneous decompression of a posterior fossa arachnoid cyst: a case report. Pediatr Neurosurg 35(3):162–163

    Article  CAS  PubMed  Google Scholar 

  67. Russo N, Domenicucci M, Beccaglia MR, Santoro A (2008) Spontaneous reduction of intracranial arachnoid cysts: a complete review. Br J Neurosurg 22(5):626–629

    Article  CAS  PubMed  Google Scholar 

  68. Al-Holou WN, Yew AY, Boomsaad ZE, Garton HJ, Muraszko KM, Maher CO (2010) Prevalence and natural history of arachnoid cysts in children. J Neurosurg Pediatr 5(6):578–585

    Article  PubMed  Google Scholar 

  69. Wang X, Chen JX, You C, Jiang S (2012) CT cisternography in intracranial symptomatic arachnoid cysts: classification and treatment. J Neurol Sci 318(1–2):125–130

    Article  PubMed  Google Scholar 

  70. Li L, Zhang Y, Li Y, Zhai X, Zhou Y, Liang P (2013) The clinical classification and treatment of middle cranial fossa arachnoid cysts in children. Clin Neurol Neurosurg 115(4):411–418

    Article  PubMed  Google Scholar 

  71. Zuckerman SL, Prather CT, Yengo-Kahn AM, Solomon GS, Sills AK, Bonfield CM (2016) Sport-related structural brain injury associated with arachnoid cysts: a systematic review and quantitative analysis. Neurosurg Focus 40(4):E9

    Article  PubMed  Google Scholar 

  72. Tsuzuki N, Katoh H, Ohtani N (2003) Chronic subdural hematoma complicating arachnoid cyst secondary to soccer-related head injury: case report. Neurosurgery 53(1):242–243

    Article  PubMed  Google Scholar 

  73. Mori K, Yamamoto T, Horinaka N, Maeda M (2002) Arachnoid cyst is a risk factor for chronic subdural hematoma in juveniles: twelve cases of chronic subdural hematoma associated with arachnoid cyst. J Neurotrauma 19(9):1017–1027

    Article  PubMed  Google Scholar 

  74. Wu X, Li G, Zhao J, Zhu X, Zhang Y, Hou K (2018) Arachnoid cyst–associated chronic subdural hematoma: report of 14 cases and a systematic literature review. World Neurosurgery 109:e118–e130

    Article  PubMed  Google Scholar 

  75. Eskandary H, Sabba M, Khajehpour F, Eskandari M (2005) Incidental findings in brain computed tomography scans of 3000 head trauma patients. Surg Neurol 63(6):550–553

    Article  PubMed  Google Scholar 

  76. Ortega HW, Vander Velden H, Reid S (2012) Incidental findings on computed tomography scans in children with mild head trauma. Clin Pediatr 51(9):872–876

    Article  Google Scholar 

  77. Rogers AJ, Maher CO, Schunk JE, Quayle K, Jacobs E, Lichenstein R, Kuppermann N (2013) Incidental findings in children with blunt head trauma evaluated with cranial CT scans. Pediatrics 132(2):e356–e363

    Article  PubMed  Google Scholar 

  78. Strahle J, Selzer BJ, Geh N, Srinivasan D, Strahle M, Martinez-Sosa M, Maher CO (2016) Sports participation with arachnoid cysts. J Neurosurg Pediatr 17(4):410–417

    Article  PubMed  Google Scholar 

  79. Maher CO, Garton HJ, Al-Holou WN, Trobe JD, Muraszko KM, Jackson EM (2013) Management of subdural hygromas associated with arachnoid cysts. J Neurosurg Pediatr 12(5):434–443

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

The main idea of the article was postulated by Mohamed El Beltagy, while literature search was performed by Abdelrhman Enayet. Both authors shared analysis of the data in the literature. The draft was written by Abdelrhman Enayet, and the manuscript was critically revised and reviewed by Mohamed El Beltagy.

Corresponding author

Correspondence to Mohamed A. El Beltagy.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Conflict of interest

The authors have no competing interests to declare that are relevant to the content of this article.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Beltagy, M.A.E., Enayet, A.E.R. Surgical indications in pediatric arachnoid cysts. Childs Nerv Syst 39, 87–92 (2023). https://doi.org/10.1007/s00381-022-05709-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-022-05709-y

Keywords

Navigation