Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients.
We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT).
Both tumors responded favorably to LITT.
LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.
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Cross, K.A., Salehi, A., Abdelbaki, M.S. et al. MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases. Childs Nerv Syst 39, 787–791 (2023). https://doi.org/10.1007/s00381-022-05660-y