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MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases



Nearly a quarter of neurofibromatosis type 1 (NF 1)- associated diencephalic low-grade tumors are refractory to chemotherapy. Addition of alternative treatment options with laser interstitial thermal therapy will have a positive impact on the outcome of these patients.


We report on two illustrated cases of pediatric NF1- associated, chemoresistant, WHO grade 1 pilocytic astrocytomas treated with laser interstitial thermal therapy (LITT).


Both tumors responded favorably to LITT.


LITT should be considered as a treatment option for chemoresistant deep-seated NF1-associated low-grade gliomas.

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Authors and Affiliations



Kevin Cross and Afshin Salehi wrote the manuscript. Kevin Cross and Afshin Salehi collected data. All authors contributed to review of the manuscript and David Limbrick oversaw the project.

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Correspondence to David D. Limbrick Jr..

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WUSM IRB approval was received for this study. No formal consent was required from subjects given the retrospective nature of this study.

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A.S. has received research equipment from Monteris.

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Cross, K.A., Salehi, A., Abdelbaki, M.S. et al. MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases. Childs Nerv Syst 39, 787–791 (2023).

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