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Neurocognitive outcomes of children with non-syndromic single-suture craniosynostosis

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Abstract

While the focus of craniosynostosis surgery is to improve head shape, neurocognitive sequelae are common and are incompletely understood. Neurodevelopmental problems that children with craniosynostosis face include cognitive and language impairments, motor delays or deficits, learning disabilities, executive dysfunction, and behavioral problems. Studies have shown that children with multiple suture craniosynostosis have more impairment than children with single-suture craniosynostosis. Children with isolated single-suture subtypes of craniosynostosis such as sagittal, metopic, and unicoronal craniosynostosis can have distinct neurocognitive profiles. In this review, we discuss the unique neurodevelopmental profiles of children with single-suture subtypes of craniosynostosis.

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Author information

Authors and Affiliations

  1. Division of Plastic and Reconstructive Surgery, Children’s Hospital of Philadelphia, PA, Philadelphia, USA

    Christopher L. Kalmar & Jordan W. Swanson

  2. Division of Neurosurgery, Children’s Hospital of Philadelphia, PA, Philadelphia, USA

    Shih-Shan Lang, Gregory G. Heuer & Alexander M. Tucker

  3. Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, PA, Philadelphia, USA

    Shih-Shan Lang & Gregory G. Heuer

  4. Department of Child & Adolescent Psychiatry and Behavioral Sciences, Children’s Hospital of Philadelphia, PA, Philadelphia, USA

    Jane E. Schreiber

  5. Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, PA, Philadelphia, USA

    Jane E. Schreiber

  6. Division of Plastic Surgery, Perelman School of Medicine at the University of Pennsylvania, PA, Philadelphia, USA

    Jordan W. Swanson

  7. Division of Neurology, Children’s Hospital of Philadelphia, PA, Philadelphia, USA

    Lauren A. Beslow

  8. Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, PA, Philadelphia, USA

    Lauren A. Beslow

  9. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, PA, Philadelphia, USA

    Lauren A. Beslow

Authors
  1. Christopher L. Kalmar
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  2. Shih-Shan Lang
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  3. Gregory G. Heuer
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  4. Jane E. Schreiber
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  5. Alexander M. Tucker
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  6. Jordan W. Swanson
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  7. Lauren A. Beslow
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Corresponding author

Correspondence to Lauren A. Beslow.

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Kalmar, C.L., Lang, SS., Heuer, G.G. et al. Neurocognitive outcomes of children with non-syndromic single-suture craniosynostosis. Childs Nerv Syst 38, 893–901 (2022). https://doi.org/10.1007/s00381-022-05448-0

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  • DOI: https://doi.org/10.1007/s00381-022-05448-0

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