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Giant, symptomatic mixed vascular malformation containing a cavernoma, developmental venous anomaly, and capillary telangiectasia in a 19-month-old infant

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Abstract

Intracranial mixed vascular malformations (MVMs) are defined as any combination of a developmental venous anomaly (DVA), cerebral cavernous malformation (CCM), capillary telangiectasia (CTG), or arteriovenous malformation (AVM) within a single, contiguous lesion. However, most MVMs described in the literature contain only 2 pathologically discrete malformations; juxtaposition of 3 or more abnormalities in a single lesion remains exceedingly rare. We present the case of a 19-month-old female with new onset focal seizures and a 4-cm right basal ganglia lesion initially believed to be an embryonal neoplasm. She subsequently underwent gross total resection (GTR) of the lesion via a transsylvian-transinsular approach. Intraoperatively, the lesion appeared to be heterogenous and highly vascular, with areas of purplish-gray friable tissue. Pathology confirmed the lesion to be a MVM containing a CCM, CTG, and a DVA. This appears to be the first reported case of such a lesion confirmed on pathology in the literature.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA

    Wendy Gaztanaga, Evan Luther, David McCarthy, Shelly Wang & John Ragheb

  2. Department of Neurosurgery, Nicklaus Children’s Hospital, Miami, FL, USA

    Shelly Wang & John Ragheb

  3. Department of Pathology, Nicklaus Children’s Hospital, Miami, FL, USA

    Gabriel Chamyan

Authors
  1. Wendy Gaztanaga
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  2. Evan Luther
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  3. David McCarthy
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  4. Gabriel Chamyan
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  5. Shelly Wang
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  6. John Ragheb
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Correspondence to Wendy Gaztanaga.

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Gaztanaga, W., Luther, E., McCarthy, D. et al. Giant, symptomatic mixed vascular malformation containing a cavernoma, developmental venous anomaly, and capillary telangiectasia in a 19-month-old infant. Childs Nerv Syst 38, 1005–1009 (2022). https://doi.org/10.1007/s00381-021-05358-7

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  • DOI: https://doi.org/10.1007/s00381-021-05358-7

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