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Intramedullary metastasis in medulloblastoma: a case report and literature review

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Abstract

Background

Cerebellar medulloblastomas are the most common malignant tumors of the posterior fossa in childhood that frequently metastasize. Leptomeningeal dissemination and distant metastasis have been associated with medulloblastomas; however, intramedullary metastases are rare with very few case reports in the literature available.

Methods

We present a case of a 3-year-old girl with a medulloblastoma who underwent surgical resection of spinal intramedullary metastases. Histopathology revealed the tumor to be an anaplastic medulloblastoma similar to the intracranial lesions. The patient subsequently underwent postoperative chemotherapy followed by radiotherapy.

Results

Following the surgery and subsequent follow-up, the patient showed a good recovery without any new neurological dysfunction.

Conclusions

Intramedullary metastasis of medulloblastoma remains a rare disease. Surgical resection could play a possible role in the management in addition to radiation and chemotherapy.

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Acknowledgements

We are grateful to the research grant from the Beijing Municipal Science & Technology Commission, PR China, No. Z171100001017140 (to AJS) and the Science Foundation of Military Medical Research and Clinical Research Foundation of PLA General Hospital in China, No. 2017FC-TSYS-2026.

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Authors and Affiliations

  1. Department of Neurosurgery, the First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China

    Hongzhen Jiang, Benzhang Tao & Aijia Shang

  2. Department of Neurosurgery, Yuquan Hospital of Tsinghua University, Beijing, 100049, China

    Tianbao Luo

Authors
  1. Hongzhen Jiang
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  2. Tianbao Luo
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  3. Benzhang Tao
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  4. Aijia Shang
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Correspondence to Aijia Shang.

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Jiang, H., Luo, T., Tao, B. et al. Intramedullary metastasis in medulloblastoma: a case report and literature review. Childs Nerv Syst 37, 2091–2095 (2021). https://doi.org/10.1007/s00381-021-05086-y

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  • DOI: https://doi.org/10.1007/s00381-021-05086-y

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