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Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country

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Multidisciplinary team meetings (MDTMs) are essential in the clinical management of pediatric central nervous system (CNS) tumors. Evaluations of the impact of MDTMs on childhood CNS tumors and clinicians’ perspectives on their effectiveness are scarce.


We retrospectively reviewed the clinical data of pediatric patients (aged <18 years) with CNS tumors diagnosed and treated in the Pediatric Hematology-Oncology Division at the University Malaya Medical Center from 2008 to 2019. We also conducted a web-based survey of the core members of the multidisciplinary team to evaluate the impact of the MDTMs.


During the pre-MDTM era (2008–2012), 29 CNS tumors were diagnosed and treated, and during the MDTM era (2014–2019), 49 CNS tumors were diagnosed and treated. The interval for histologic diagnosis was significantly shorter during the MDTM era (p=0.04), but the interval from diagnosis to chemotherapy or radiotherapy and the 5-year overall survival of the 78 patients did not improve (62.1% ± 9.0% vs. 68.8% ± 9.1%; p=0.184). However, the 5-year overall survival of patients with medulloblastoma or rare tumors significantly improved in the MDTM era (p=0.01). Key factors that contributed to delayed treatment and poor outcomes were postoperative complications, the facility’s lack of infrastructure, poor parental education about early treatment, cultural beliefs in alternative medicine, and infection during chemotherapy. Eighteen clinicians responded to the survey; they felt that the MDTMs were beneficial in decision-making and enhanced the continuity of coordinated care.


MDTMs significantly reduced the diagnostic interval and improved the overall outcomes. However, delayed treatment remains a major challenge that requires further attention.

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We thank Dr. Angela McArthur for the scientific editing of this manuscript.

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Authors and Affiliations



Revathi Rajagopal, Tsiao Yi Yap, Jasmin Loh, Nicholas G. Gottardo, Daniel C Moreira, and Ibrahim Qaddoumi designed the study. Jen Chun Foo and Vida Jawin collected the data. Nor Faizal Ahmad Bahuri, Dharmendra Ganesan, Kein Seong Mun, and Jen Chun Foo coordinated the web-based cross-sectional survey. Revathi Rajagopal and Daniel C Moreira analyzed the data. Jen Chun, Vida Jawin, Daniel Moreira, and Revathi Rajagopal drafted the manuscript. All authors reviewed and revised the manuscript.

Corresponding author

Correspondence to Revathi Rajagopal.

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Ethics approval

Study approval was obtained from the University Malaya Medical Center Medical Research Ethics Committee for patient data collection (MREC ID: 201914-6968). The UMMC Ethics Committee waived the need for written informed consent from patients and families.

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The authors have no conflicts of interest to declare.

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This report is from a Global Alliance Pediatric Neuro-Oncology quality improvement project conducted at the University Malaya Medical Center, Kuala Lumpur, Malaysia. Clinicians from various departments and centers participated in this study.

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Foo, J.C., Jawin, V., Yap, T.Y. et al. Conduct of neuro-oncology multidisciplinary team meetings and closing the “gaps” in the clinical management of childhood central nervous system tumors in a middle-income country. Childs Nerv Syst 37, 1573–1580 (2021).

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