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A rare case of atypical spinal neurocytoma with EGFR mutation in a 12-year-old boy

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Abstract

Spinal neurocytoma (SN), although frequently reportedly as tumors of the central nervous system (CNS), are a distinct class of tumors, which can achieve a better prognosis following subtotal or gross total tumor resection. Nonetheless, even with the premise of successful treatment after tumor resection, poor prognosis after treatment due to the SN high proliferation index (typically known as atypical SN) have been reported. Over the past two decades, atypical SN was only reported in four pediatric cases, amidst the lingering controversy surrounding its postoperative adjuvant therapy. Thus, herein, we report a unique case of atypical SN with epidermal growth factor receptor (EGFR) amplification mutation in a 12-year-old boy. We, however, also highlighted the significance of radiotherapy and target therapy for patients with SN.

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Data availability

The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

Authors

Contributions

Beibei Yu and Jiatong Li developed the idea of the study, participated in its design and coordination and helped to draft the manuscript. Linkai Jing and Weitao Man contributed to the acquisition and interpretation of data. Guihuai Wang provided critical review and substantially revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Guihuai Wang.

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The authors report no conflicts of interest.

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Our institution’s committee on human research gave approval for this study, and all participants gave informed consent.

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Informed consent was obtained from legal guardians.

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The participant has consented to the submission of the case report to the journal.

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Jiatong Li is the Co-first author

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Yu, B., Li, J., Jing, L. et al. A rare case of atypical spinal neurocytoma with EGFR mutation in a 12-year-old boy. Childs Nerv Syst 37, 2399–2403 (2021). https://doi.org/10.1007/s00381-020-04912-z

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  • DOI: https://doi.org/10.1007/s00381-020-04912-z

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