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Subependymal hyperintense layer on CISS sequence: An MRI study

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Abstract

Purpose

The present study aimed to explore the subependymal layers overlying the cerebral ventricles using magnetic resonance imaging.

Methods

A total of 69 outpatients underwent constructive interference in steady-state (CISS) sequence in thin-sliced, coronal, and sagittal sections.

Results

The subependymal layers were delineated as linear hyperintensities, coursing along the outer margins of the ventricular walls. On coronal images, the hyperintensities surrounding the anterior horn of the lateral ventricle were identified in 97% of patients, while those of the third ventricle were identified in 96% of patients. In the trigone and posterior horn of the lateral ventricle, the hyperintensities were delineated in all patients. On sagittal images, subependymal hyperintensities were identified in all. At the level of the anterior horn and third ventricle, the subependymal hyperintensities were found to communicate with the Virchow-Robin spaces (VRSs) in 68% and 65% of patients, respectively. At the level of the trigone and posterior horn of the lateral ventricle, the VRSs communicated with the subependymal hyperintensities in 83% of patients.

Conclusions

Subependymal hyperintensity may represent an inflow passage of the VRSs that jointly contribute to efficient transependymal migration of the interstitial fluid into the ventricular cerebrospinal fluid.

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Authors and Affiliations

  1. Department of Neurological Surgery, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan

    Satoshi Tsutsumi & Hisato Ishii

  2. Division of Radiological Technology, Medical Satellite Yaesu Clinic, Tokyo, Japan

    Hideo Ono

Authors
  1. Satoshi Tsutsumi
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  2. Hideo Ono
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  3. Hisato Ishii
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Contributions

Satoshi Tsutsumi and Hideo Ono developed the study project.

Hisato Ishii collected and managed the data.

Satoshi Tsutsumi and Hisato Ishii analyzed the data.

Satoshi Tsutsumi wrote the manuscript.

Corresponding author

Correspondence to Satoshi Tsutsumi.

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Conflict of interest

The authors have no conflicts of interest concerning the materials and methods used in this study or the findings presented in this manuscript.

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Tsutsumi, S., Ono, H. & Ishii, H. Subependymal hyperintense layer on CISS sequence: An MRI study. Childs Nerv Syst 37, 147–152 (2021). https://doi.org/10.1007/s00381-020-04707-2

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  • DOI: https://doi.org/10.1007/s00381-020-04707-2

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