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Risk factors associated with epilepsy development in children with cerebral palsy

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Abstract

Objectives

Epilepsy is one of the most common and important comorbidity among patients with cerebral palsy (CP). The purpose of this study was to determine the risk factors predicting the development of epilepsy considering prenatal, perinatal, and natal characteristics; associated impairments; and cranial imaging findings in our patient population with cerebral palsy at a tertiary center in Istanbul, Turkey.

Methods

This retrospective study consisted of 234 children aged between 3 and 18 years of age. Children were divided into two groups as CP patients with epilepsy (126 patients) and CP patients without epilepsy (108 patients). Demographic features and clinical and cranial magnetic resonance imaging (cMRI) findings were compared between the two groups.

Results

Presence of family history of epilepsy, history of neonatal seizure especially in the first 72 h of life, quadriplegic type of CP, severe degree of gross motor function and fine motor disorders, and moderate to severe mental retardation or psycho-social developmental delay were determined as risk factors for the development of epilepsy in CP patients. Also, an increased risk of epilepsy was detected in term infants and appropriate for gestational age (2500–4000 g) infants. On the other hand, presence of parental consanguinity, being born from a primiparous mother, age of mother at birth, mode of delivery, presence of multiple gestation and labor problems, history of follow-up in neonatal intensive care unit and intubation, and cMRI findings were not significant risk factors for the development of epilepsy in CP.

Conclusion

Predicting epilepsy development by determining the risk factors in patients with CP might be useful because knowing the risk factors could provide close follow-up of these patients for epilepsy.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Pediatric Neurology, Medeniyet University, Istanbul, Turkey

    Elif Karatoprak

  2. Department of Pediatric Neurology, Umraniye Training and Research Hospital, Istanbul, Turkey

    Gülhan Sözen

  3. Cerrahpasa Faculty of Medicine, Department of Pediatric Neurology, Istanbul University, Istanbul, Turkey

    Sema Saltık

Authors
  1. Elif Karatoprak
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  2. Gülhan Sözen
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  3. Sema Saltık
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Corresponding author

Correspondence to Elif Karatoprak.

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The study was approved by the local ethics committee (2012/25/D).

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The authors declared no conflict of interest.

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Karatoprak, E., Sözen, G. & Saltık, S. Risk factors associated with epilepsy development in children with cerebral palsy. Childs Nerv Syst 35, 1181–1187 (2019). https://doi.org/10.1007/s00381-019-04152-w

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  • DOI: https://doi.org/10.1007/s00381-019-04152-w

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