Skip to main content
Log in

Diffuse intrinsic pontine glioma ventricular peritoneal shunt metastasis: a case report and literature review

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Dissemination of diffuse intrinsic pontine glioma (DIPG) outside the central nervous system is exceptional. Here, we present a child diagnosed with DIPG who developed seeding along the track of the ventriculoperitoneal shunt and review the literature on this unusual occurrence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Hargrave D, Bartels U, Bouffet E (2006) Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol 7:241–248

    Article  PubMed  Google Scholar 

  2. Gururangan S, McLaughlin CA, Brashears J, Watral MA, Provenzale J et al (2006) Incidence and patterns of neuraxis metastases in children with diffuse pontine glioma. J Neuro-Oncol 77:207–212

    Article  Google Scholar 

  3. Sethi R, Allen J, Donahue B, Karajannis M, Gardner S, Wisoff J, Kunnakkat S, Mathew J, Zagzag D, Newman K, Narayana A (2011) Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma. J Neuro-Oncol 102:121–127

    Article  Google Scholar 

  4. Vanan MI, Eisenstat DD (2015) DIPG in children - what can we learn from the past? Front Oncol 5:237

    Article  PubMed  PubMed Central  Google Scholar 

  5. Janssens GO, Gandola L, Bolle S, Mandeville H, Ramos-Albiac M, van Beek K, Benghiat H, Hoeben B, Morales la Madrid A, Kortmann RD, Hargrave D, Menten J, Pecori E, Biassoni V, von Bueren AO, van Vuurden DG, Massimino M, Sturm D, Peters M, Kramm CM (2017) Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: a matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group. Eur J Cancer 73:38–47

    Article  PubMed  Google Scholar 

  6. Morales La Madrid A, Santa-Maria V, Cruz Martinez O, Mora J, Puerta Roldan P et al (2017) Second re-irradiation for DIPG progression, re-considering “old strategies” with new approaches. Child’s Nerv Syst 33:849–852

    Article  Google Scholar 

  7. Lassaletta A, Strother D, Laperriere N, Hukin J, Vanan MI, Goddard K, Lafay-Cousin L, Johnston DL, Zelcer S, Zapotocky M, Rajagopal R, Ramaswamy V, Hawkins C, Tabori U, Huang A, Bartels U, Bouffet E (2018) Reirradiation in patients with diffuse intrinsic pontine gliomas: the Canadian experience. Pediatr Blood Cancer 65:e26988

    Article  PubMed  Google Scholar 

  8. Rickert CH (2003) Extraneural metastases of paediatric brain tumours. Acta Neuropathol 105:309–327

    PubMed  Google Scholar 

  9. Rickert CH (1998) Abdominal metastases of pediatric brain tumors via ventriculo-peritoneal shunts. Child’s Nerv Syst 14:10–14

    Article  CAS  Google Scholar 

  10. Barajas RF Jr, Phelps A, Foster HC, Courtier J, Buelow BD et al (2015) Metastatic diffuse intrinsic pontine glioma to the peritoneal cavity via ventriculoperitoneal shunt: case report and literature review. J Neurol Surg Rep 76:e91–e96

    Article  PubMed  PubMed Central  Google Scholar 

  11. Newton HB, Rosenblum MK, Walker RW (1992) Extraneural metastases of infratentorial glioblastoma multiforme to the peritoneal cavity. Cancer 69:2149–2153

    Article  CAS  PubMed  Google Scholar 

  12. Mosca L, Baldini M (1976) Early glial tumor metastases through a ventriculo-atrial shunt. Tumori 62:47–54

    Article  CAS  PubMed  Google Scholar 

  13. Jacques TS, Miller K, Rampling D, Gatscher S, Harding B (2008) Peritoneal dissemination of a malignant glioma. Cytopathology 19:264–266

    Article  CAS  PubMed  Google Scholar 

  14. Wakamatsu T, Matsuo T, Kawano S, Teramoto S, Matsumura H (1971) Glioblastoma with extracranial metastasis through ventriculopleural shunt. Case report. J Neurosurg 34:697–701

    Article  CAS  PubMed  Google Scholar 

  15. Nawashiro H, Otani N, Katoh H, Ohnuki A, Ogata S, Shima K (2002) Subcutaneous seeding of pancreatic carcinoma along a VP shunt catheter. The Lancet. Oncology 3:683

    Article  PubMed  Google Scholar 

  16. Ko JH, Lu PH, Tang TC, Hsu YH (2011) Metastasis of primary CNS lymphoma along a ventriculoperitoneal shunt. J Clin Oncol 29:e823–e824

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eric Bouffet.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gelder, C.L., Hawkins, C., Zapotocky, M. et al. Diffuse intrinsic pontine glioma ventricular peritoneal shunt metastasis: a case report and literature review. Childs Nerv Syst 35, 861–864 (2019). https://doi.org/10.1007/s00381-019-04069-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-019-04069-4

Keywords

Navigation