Child's Nervous System

, Volume 35, Issue 1, pp 63–72 | Cite as

Monitoring optic chiasmatic-hypothalamic glioma volumetric changes by MRI in children under clinical surveillance or chemotherapy

  • Nathalia Cunha CalixtoEmail author
  • Gustavo Novelino Simão
  • Antonio Carlos dos Santos
  • Ricardo Santos de Oliveira
  • Luiz Guilherme Darrigo Junior
  • Elvis Terci Valera
  • Murilo Bicudo Cintra
  • Alessandro Spano Mello
Original Paper



Optic pathway gliomas represent 5% of pediatric brain tumors and are typically low-grade lesions. Because of their unpredictable clinical course, adequate treatment approaches have been controversial, involving surveillance, surgery, chemotherapy, and radiotherapy. In this study, we use volumetric imaging to compare evolution of optic chiasmatic-hypothalamic gliomas (OCHG) treated with and without chemotherapy, analyzing tumor volume variation during the overall period.


A total of 45 brain MRI were retrospectively analyzed for 14 patients with OCHG. Volumetric assessment of the lesions was performed by a neuroradiologist, using software DISPLAY. OCHG patients were allocated into two groups: group 1 (n = 8) who underwent chemotherapy and group 2 (n = 6) who did not receive chemotherapy. Outcome analysis was performed comparing tumor volume evolution of these two groups.


The results showed a reduction of 4.4% of the volume of the lesions for group 1 after the end of chemotherapy, with an increase of 5.3% in volume in the late follow-up examination. For group 2, we found a slight reduction (5%) of the overall volume of the lesions, both with no statistical significance (p > 0.05).


From the limited series analyzed in this study, no significant differences were observed in relation to the volume change of lesions treated or not treated with chemotherapy. Larger prospective clinical trials are needed to better evaluate the effect of chemotherapy and radiological response of OCHG.


Optic pathway gliomas (OPG) Radiology Pediatric neurosurgery Chemotherapy 


Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Supplementary material

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Nathalia Cunha Calixto
    • 1
    Email author
  • Gustavo Novelino Simão
    • 1
  • Antonio Carlos dos Santos
    • 1
  • Ricardo Santos de Oliveira
    • 2
  • Luiz Guilherme Darrigo Junior
    • 3
  • Elvis Terci Valera
    • 3
  • Murilo Bicudo Cintra
    • 1
  • Alessandro Spano Mello
    • 1
  1. 1.Division of Radiology, Department of Clinics, University Hospital of Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão PretoBrazil
  2. 2.Division of Pediatric Neurosurgery, Department of Surgery and Anatomy, University Hospital of Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão PretoBrazil
  3. 3.Division of Pediatric Neuroncology, Department of Pediatrics, University Hospital of Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão PretoBrazil

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