Child's Nervous System

, Volume 34, Issue 3, pp 395–400 | Cite as

Vagal nerve stimulation for medically refractory epilepsy in Angelman syndrome: a series of three cases

  • Krystal L. Tomei
  • Christine Y. Mau
  • Michael Ghali
  • Jayoung Pak
  • Ira M. GoldsteinEmail author
Review Paper



We describe three children with Angelman syndrome and medically refractory epilepsy.


Case series of three pediatric patients with Angelman syndrome and medically refractory epilepsy. All three patients failed medical treatment and were recommended for vagal nerve stimulator (VNS) implantation.


Following VNS implantation, all three patients experienced reduction in seizure frequency greater than that afforded by medication alone.


We present vagal nerve stimulator implantation as a viable treatment option for medically refractory epilepsy associated with Angelman syndrome.


Vagal nerve stimulation Angelman syndrome Medically refractory epilepsy 


Compliance with ethical standards


VNS is currently FDA approved for individuals greater than 12 years of age and all patients in this series were under 12.

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Krystal L. Tomei
    • 1
  • Christine Y. Mau
    • 2
  • Michael Ghali
    • 3
  • Jayoung Pak
    • 4
  • Ira M. Goldstein
    • 5
    Email author
  1. 1.University Hospitals Case Medical CenterRainbow Babies and Children’s HospitalClevelandUSA
  2. 2.Department of Neurological SurgeryPenn State Milton S. Hershey Medical CenterHersheyUSA
  3. 3.Department of General SurgeryPenn State Milton S. Hershey Medical CenterHersheyUSA
  4. 4.Department of NeurologyRutgers New Jersey Medical School NewarkNewarkUSA
  5. 5.Department of Neurological SurgeryRutgers New Jersey Medical SchoolNewarkUSA

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