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Imaging findings in congenital Zika virus infection syndrome: an update

Child's Nervous System volume 34, pages 85–93 (2018)Cite this article

Abstract

Background

Zika virus (ZIKV) is a neurotropic and neurotoxic RNA Flavivirus prompt to cause severe fetal brain dysmorphisms during pregnancy, a period of rapid and critical central nervous system development. A wide range of clinico-radiological findings of congenital ZIKV infections were reported in the literature, such as microcephaly, overlapping sutures, cortical migrational and corpus callosum abnormalities, intracranial calcifications, ventriculomegaly, brain stem and cerebellar malformations, spinal cord involvement, and joint contractures. ZIKV is also related to other severe neurological manifestations in grown-up individuals such as Guillain-Barré syndrome and encephalomyelitis.

Purpose

Our purpose is to review the radiological central nervous system abnormalities of congenital ZIKV infection syndrome on different imaging modalities.

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Acknowledgements

We gratefully acknowledge the members of the Brazilian Network BRAZIKA (Rede Internacional de Estudos Sobre Zika no Brasil).

Financial support

This work was funded by different grants from the Brazilian Council for Development of Science and Technology (CNPq, Ref: 440909/2016-3), the CAPES Foundation, the Brazilian Ministry of Education (Ref. 88887.116625/2016-01), the Rio de Janeiro Foundation for the Support of Science (FAPERJ, Ref: E-26/201.319/2016), and intramural grants from the D’Or Institute for Research and Education (IDOR, PNeuro).

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Authors and Affiliations

  1. D’Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro, 30, Botafogo, Rio de Janeiro, 22281-100, Brazil

    Andrea Silveira de Souza, Luis Alberto Moreira de Souza & Fernanda Tovar-Moll

  2. Department of Diagnostic Imaging, Federal University of São Paulo, São Paulo, Brazil

    Patrícia Soares de Oliveira-Szjenfeld

  3. Foundation Institute for Education and Research in Diagnostic Imaging (FIDI), Federal University of São Paulo, São Paulo, Brazil

    Patrícia Soares de Oliveira-Szjenfeld

  4. Research Institute Professor Amorim Neto (IPESQ), Campina Grande, PB, Brazil

    Adriana Suely de Oliveira Melo & Alba Gean Medeiros Batista

  5. UNIFACISA, Campina Grande, PB, Brazil

    Adriana Suely de Oliveira Melo

  6. Hospital Pedro I, Campina Grande, PB, Brazil

    Alba Gean Medeiros Batista

  7. Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

    Fernanda Tovar-Moll

Authors
  1. Andrea Silveira de Souza
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  2. Patrícia Soares de Oliveira-Szjenfeld
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  3. Adriana Suely de Oliveira Melo
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  5. Alba Gean Medeiros Batista
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Contributions

A.S.S. and F.T.M. wrote and edited the initial drafts. All authors reviewed the final draft.

Corresponding author

Correspondence to Fernanda Tovar-Moll.

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de Souza, A.S., de Oliveira-Szjenfeld, P.S., de Oliveira Melo, A.S. et al. Imaging findings in congenital Zika virus infection syndrome: an update. Childs Nerv Syst 34, 85–93 (2018). https://doi.org/10.1007/s00381-017-3637-1

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  • DOI: https://doi.org/10.1007/s00381-017-3637-1

Keywords

  • Zika
  • ZIKV
  • Microcephaly
  • Congenital malformation
  • Brain calcifications
  • Ventriculomegaly
  • Arthrogryposis