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Child's Nervous System

, Volume 34, Issue 1, pp 85–93 | Cite as

Imaging findings in congenital Zika virus infection syndrome: an update

  • Andrea Silveira de Souza
  • Patrícia Soares de Oliveira-Szjenfeld
  • Adriana Suely de Oliveira Melo
  • Luis Alberto Moreira de Souza
  • Alba Gean Medeiros Batista
  • Fernanda Tovar-MollEmail author
Focus Session

Abstract

Background

Zika virus (ZIKV) is a neurotropic and neurotoxic RNA Flavivirus prompt to cause severe fetal brain dysmorphisms during pregnancy, a period of rapid and critical central nervous system development. A wide range of clinico-radiological findings of congenital ZIKV infections were reported in the literature, such as microcephaly, overlapping sutures, cortical migrational and corpus callosum abnormalities, intracranial calcifications, ventriculomegaly, brain stem and cerebellar malformations, spinal cord involvement, and joint contractures. ZIKV is also related to other severe neurological manifestations in grown-up individuals such as Guillain-Barré syndrome and encephalomyelitis.

Purpose

Our purpose is to review the radiological central nervous system abnormalities of congenital ZIKV infection syndrome on different imaging modalities.

Keywords

Zika ZIKV Microcephaly Congenital malformation Brain calcifications Ventriculomegaly Arthrogryposis 

Notes

Acknowledgements

We gratefully acknowledge the members of the Brazilian Network BRAZIKA (Rede Internacional de Estudos Sobre Zika no Brasil).

Financial support

This work was funded by different grants from the Brazilian Council for Development of Science and Technology (CNPq, Ref: 440909/2016-3), the CAPES Foundation, the Brazilian Ministry of Education (Ref. 88887.116625/2016-01), the Rio de Janeiro Foundation for the Support of Science (FAPERJ, Ref: E-26/201.319/2016), and intramural grants from the D’Or Institute for Research and Education (IDOR, PNeuro).

Author contributions

A.S.S. and F.T.M. wrote and edited the initial drafts. All authors reviewed the final draft.

Compliance with ethical standards

Conflict of interest

All authors reported no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Andrea Silveira de Souza
    • 1
  • Patrícia Soares de Oliveira-Szjenfeld
    • 2
    • 3
  • Adriana Suely de Oliveira Melo
    • 4
    • 5
  • Luis Alberto Moreira de Souza
    • 1
  • Alba Gean Medeiros Batista
    • 4
    • 6
  • Fernanda Tovar-Moll
    • 1
    • 7
    Email author
  1. 1.D’Or Institute for Research and Education (IDOR)Rio de JaneiroBrazil
  2. 2.Department of Diagnostic ImagingFederal University of São PauloSão PauloBrazil
  3. 3.Foundation Institute for Education and Research in Diagnostic Imaging (FIDI)Federal University of São PauloSão PauloBrazil
  4. 4.Research Institute Professor Amorim Neto (IPESQ)Campina GrandeBrazil
  5. 5.UNIFACISACampina GrandeBrazil
  6. 6.Hospital Pedro ICampina GrandeBrazil
  7. 7.Federal University of Rio de Janeiro (UFRJ)Rio de JaneiroBrazil

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