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Letter to the editor re Sredni et al.: spontaneous involution of pediatric low-grade gliomas: high expression of cannabinoid receptor 1 (CNR1) at the time of diagnosis may indicate involvement of the endocannabinoid system (2016)

Dear Editor:

I wish to compliment Sredni et al. [1] for their report “Spontaneous involution of pediatric low-grade gliomas: high expression of cannabinoid receptor 1 (CNR1) at the time of diagnosis may indicate involvement of the endocannabinoid system.” They found that incompletely resected pediatric low-grade gliomas which remained stable or involuted spontaneously expressed higher levels of the cannabinoid receptor 1 (CNR1) than those tumors which progressed. They suggested that spontaneous involution of these pediatric low-grade gliomas may have been induced by endocannabinoids. I found this particularly interesting in the light of our previous report of two incompletely resected septum pellucidum pediatric low-grade astrocytomas that involuted spontaneously concurrent with the use of cannabis [2]. I wonder if one might be able to identify a population of low-grade gliomas and perhaps other brain tumors with elevated levels of CNR1 that might be particularly susceptible to involution with the use of cannabis. This “drug” could then be potentially used as a chemotherapeutic agent in such patients.

References

  1. Sredni ST, Huang CC, Suzuki M, Pundy T, Chou P, Tomita T (2016) Spontaneous involution of pediatric low-grade gliomas: high expression of cannabinoid receptor 1 (CNR1) at the time of diagnosis may indicate involvement of the endocannabinoid system. Child’s Nervous System : ChNS: Official Journal of the International Society for Pediatric Neurosurgery 32:2061–2067

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  2. Foroughi M, Hendson G, Sargent MA, Steinbok P (2011) Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas—possible role of cannabis inhalation. Child’s Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery 27:671–679

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Steinbok, P. Letter to the editor re Sredni et al.: spontaneous involution of pediatric low-grade gliomas: high expression of cannabinoid receptor 1 (CNR1) at the time of diagnosis may indicate involvement of the endocannabinoid system (2016). Childs Nerv Syst 33, 393 (2017). https://doi.org/10.1007/s00381-016-3333-6

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  • DOI: https://doi.org/10.1007/s00381-016-3333-6

Keywords

  • Public Health
  • High Expression
  • Brain Tumor
  • Elevated Level
  • Astrocytoma