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A comparison of clinicopathological features and surgical outcomes between pediatric skull base and non-skull base meningiomas

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Abstract

Object

The purpose of this study is to analyze and compare the clinicopathological characteristics and surgical outcomes between skull base and non-skull base meningiomas in pediatric population.

Methods

We retrospectively analyzed a total of 140 cases of pediatric meningiomas surgically treated in our department from January 2005 to July 2015 and compared the clinicopathological characteristics and surgical outcomes between skull base and non-skull base meningiomas.

Results

Of all the pediatric meningiomas, 50 (35.8 %) were located at the skull base and 90 (64.2 %) were located at the non-skull base. Skull base and non-skull base meningiomas had a similar sex distribution (male/female = 1:1 in skull base meningiomas and male/female = 1.5:1 in non-skull base meningiomas) (P = 0.288) and high-grade meningioma occurrence rate (P = 0.569). In addition, the mean age of non-skull base meningiomas was 12.5 years which was younger than that of skull base meningiomas (14.2 years) (P = 0.019), and the preoperative tumor size was smaller in skull base (mean size = 4.7 cm in skull base meningiomas and mean size = 5.7 cm in non-skull base meningiomas) (P = 0.020). Gross total resection was achieved in 64 non-skull base patients (73.9 %) and 26 skull base patients (52 %) (P = 0.046). Patients with gross total resection had better progression free survival (PFS) than those with subtotal resection.

Conclusion

Pediatric skull base and non-skull base meningiomas are similar in sex distribution and high-grade meningioma occurrence rate. In comparison with non-skull base ones, pediatric skull base meningiomas occur at elder age and are smaller in size and they are more likely to be incompletely resected. Gross total resection and early treatment are recommended to prolong PFS of pediatric patients.

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Acknowledgments

We thank Dr. Junmei Wang for her help in the pathological examination.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Beijing, 100050, China

    Zhicen Li, Hao Li, Yuming Jiao, Ji Ma, Shuo Wang, Jizong Zhao & Yong Cao

  2. China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China

    Zhicen Li, Hao Li, Yuming Jiao, Ji Ma, Shuo Wang, Jizong Zhao & Yong Cao

Authors
  1. Zhicen Li
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  2. Hao Li
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  3. Yuming Jiao
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  4. Ji Ma
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  5. Shuo Wang
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  6. Jizong Zhao
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  7. Yong Cao
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Corresponding author

Correspondence to Yong Cao.

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The authors have declared no potential conflict of interest.

Ethical approval

This research was approved by the research ethics committee of the Beijing Tiantan Hospital, Capital Medical University, Beijing.

Additional information

Zhicen Li and Hao Li contribute equally to this study

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Li, Z., Li, H., Jiao, Y. et al. A comparison of clinicopathological features and surgical outcomes between pediatric skull base and non-skull base meningiomas. Childs Nerv Syst 33, 595–600 (2017). https://doi.org/10.1007/s00381-016-3278-9

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  • DOI: https://doi.org/10.1007/s00381-016-3278-9

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