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Recurrent adult-type fibrosarcoma of the frontal bone in a child

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Abstract

Introduction

Primary, adult-type bone fibrosarcoma is an uncommon, malignant spindle-cell tumor of fibroblastic origin, rarely affecting children. Most frequently diagnosed among bone malignancies in the past, improved diagnostic techniques and further restrictive classification criteria have currently made the diagnosis of fibrosarcoma very unusual.

Case report

We hereby report the case of a 7-year-old child with a right frontal swelling mass. A computed tomography scan showed an osteolytic lesion of the right frontal bone, involving the diploe and the outer table of the skull. An en bloc surgical excision, followed by a thorough immunohistological evaluation, led to the diagnosis of fibroblastic proliferation, with low cellularity and minimal atypias. The patient had four recurrences during the 4-year follow-up. With an increasing histological grade at recurrences, a diagnosis of adult-type fibrosarcoma was made.

Conclusion

To the best of the authors’ knowledge, this is the first reported case of an adult-type fibrosarcoma arising in the frontal bone of a child.

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Authors and Affiliations

  1. Department of Anatomic Pathology, Catholic University, Largo F. Vito 1, 00168, Rome, Italy

    Mariangela Novello & Antonella Coli

  2. Pediatric Neurosurgery, Catholic University, Rome, Italy

    Concezio Di Rocco, Gianpiero Tamburrini & Paolo Frassanito

  3. Pediatric Neurosurgery, International Neuroscience Institute, Hannover, Germany

    Concezio Di Rocco & Daniel T. Aguirre

  4. Division of Anatomic Pathology, Miller School of Medicine, University of Miami, Miami, FL, USA

    Andrew E. Rosenberg

Authors
  1. Mariangela Novello
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  2. Concezio Di Rocco
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  3. Gianpiero Tamburrini
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  4. Paolo Frassanito
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  5. Daniel T. Aguirre
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  6. Andrew E. Rosenberg
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  7. Antonella Coli
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Corresponding author

Correspondence to Antonella Coli.

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The authors declare that they have no conflict of interest.

Ethical statement

The present report was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Novello, M., Di Rocco, C., Tamburrini, G. et al. Recurrent adult-type fibrosarcoma of the frontal bone in a child. Childs Nerv Syst 32, 1169–1173 (2016). https://doi.org/10.1007/s00381-015-2998-6

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  • DOI: https://doi.org/10.1007/s00381-015-2998-6

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