Abstract
Summary
To present the clinical feature, radiographic characteristic, treatment and prognosis of an 11 years old girl with cervical intervertebral disc calcification combined with ossification of posterior longitudinal ligament(OPLL).
Background
Calcification is the degeneration of intervertebral disc, mostly occurs in the cervical segment. The pediatric cervical intervertebral disc calcification associated with OPLL is very rare. The etiology and treatment guidelines of this complex are poorly known.
Method
An 11 years old girl experienced neck pain for 3 months,aggravated for half a month. Neurological examination revealed the limitation of cervical spine motion and numbness of the upper left extremity. The spine radiograph, computed tomography and magnetic resonance imaging confirmed the diagnosis of cervical intervertebral disc calcification accompanied with OPLL. Conservative intervention was performed, followed up with an observation for 6 months.
Result
On admission, the spine radiograph and computed tomography found the calcified intervertebral disc of C5/6 and ossified posterior longitudinal ligament at C5/6,C6 level, leading to spinal canal stenosis and spine cord compression. After a two-week in-hospital conservative treatment, the patient’s neurologic symptoms were relieved. Two months later, the computed tomography confirmed the calcification of C5/6 intervertebral disc and ossified mass decreased significantly, spinal stenosis subsided. Six months later, the patient felt no discomfort, the computed tomography showed the ossified mass completely disappeared, only a small calcification remained at C5/6 intervertebral disc.
Conclusion
Intervertebral disc calcification associated with OPLL is extremely rare in children. In this case, OPLL is a temporary condition highly related to the disease process of Intervertebral disc calcification. The patient has a satisfactory recovery after non-surgical intervention. Conservative treatment is a prospective choice.
Similar content being viewed by others
References
Smith LJ, Nerurkar NL, Choi KS, Harfe BD, Elliott DM (2011) Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech 4(1):31–41
Tsutsumi S, Yasumoto Y, Ito M (2011) Idiopathic intervertebral disk calcification in childhood: a case report and review of literature. Childs Nerv Syst 27(7):1045–1051
Du JJ, Meng H, Cao YJ, Li FQ, Luo ZJ (2012) Calcification of the intervertebral disc and posterior longitudinal ligament in children. J Spinal Disord Tech 25(1):59–63
Fu Z, Shi J, Jia L Jr, Yuan W Jr, Guan Z (2011) Intervertebral thoracic disc calcification associated with ossification of posterior longitudinal ligament in an eleven-year-old child. Spine (Phila Pa 1976) 36(12):E808–E810
Hristova GI, Jarzem P, Ouellet JA, Roughley PJ et al (2011) Calcification in human intervertebral disc degeneration and scoliosis. J Orthop Res 29(12):1888–1895
Rutges J, Creemers LB, Dhert W, Milz S et al (2010) Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration. Osteoarthr Cartil 18(3):416–423
Tsuyama N (1984) Ossification of the posterior longitudinal ligament of the spine. Clin Orthop Relat Res 184:71–84
Matsunaga S, Sakou T (2012) Ossification of the posterior longitudinal ligament of the cervical spine: etiology and natural history. Spine (Phila Pa 1976) 37(5):E309–E314
Saetia K, Cho D, Lee S, Kim DH, Kim SD (2011) Ossification of the posterior longitudinal ligament: a review. Neurosurg Focus 30(3):E1
Matsunaga S, Sakou T, Hayashi K, Ishidou Y, Hirotsu M, Komiya S (2002) Trauma-induced myelopathy in patients with ossification of the posterior longitudinal ligament. J Neurosurg 97(2 Suppl):172–175
Yang HS, Chen DY, Yuan W, Yang LL, Tsai N, Lin QS (2010) Paresis associated with aconuresis caused by intervertebral disc calcification at c7-t1: a case report and review of the literature. Spine (Phila Pa 1976) 35(10):E434–E439
Urban JP, Smith S, Fairbank JC (2004) Nutrition of the intervertebral disc. Spine (Phila Pa 1976) 29(23):2700–2709
Spapens N, Wouters C, Moens P (2010) Thoracolumbar intervertebral disc calcifications in an 8-year-old boy: case report and review of the literature. Eur J Pediatr 169(5):577–580
Bajard X, Renault F, Benharrats T, Mary P, Madi F, Vialle R (2010) Intervertebral disc calcification with neurological symptoms in children: report of conservative treatment in two cases. Childs Nerv Syst 26(7):973–978
Moore RJ (2006) The vertebral endplate: disc degeneration, disc regeneration. Eur Spine J 15(Suppl 3):S333–S337
Hsieh AH, Twomey JD (2010) Cellular mechanobiology of the intervertebral disc: new directions and approaches. J Biomech 43(1):137–145
Rudert M, Tillmann B (1993) Detection of lymph and blood vessels in the human intervertebral disc by histochemical and immunohistochemical methods. Ann Anat 175(3):237–242
Ayotte DC, Ito K, Perren SM, Tepic S (2000) Direction-dependent constriction flow in a poroelastic solid: the intervertebral disc valve. J Biomech Eng 122(6):587–593
Terayama K (1989) Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine (Phila Pa 1976) 14(11):1184–1191
Stetler WR, La Marca F, Park P (2011) The genetics of ossification of the posterior longitudinal ligament. Neurosurg Focus 30(3):E7
Matsunaga S, Sakou T, Taketomi E, Nakanisi K (1996) Effects of strain distribution in the intervertebral discs on the progression of ossification of the posterior longitudinal ligaments. Spine (Phila Pa 1976) 21(2):184–189
Resnick D, Guerra J Jr, Robinson CA, Vint VC (1978) Association of diffuse idiopathic skeletal hyperostosis (DISH) and calcification and ossification of the posterior longitudinal ligament. AJR Am J Roentgenol 131(6):1049–1053
Hanamoto T, Miura A, Daido H, Yamamoto M, Takeda N, Yasuda K (2001) Hypophosphatemic rickets with normoalkaliphosphatemia, ossification of the posterior longitudinal ligament and yellow ligament. Nihon Naika Gakkai Zasshi 90(6):1073–1075
Inamasu J, Guiot BH, Sachs DC (2006) Ossification of the posterior longitudinal ligament: an update on its biology, epidemiology, and natural history. Neurosurgery 58(6):1027–1039, discussion 1027-1039
Beluffi G, Fiori P, Sileo C (2009) Intervertebral disc calcifications in children. Radiol Med 114(2):331–341
Matsunaga S, Sakou T, Taketomi E, Komiya S (2004) Clinical course of patients with ossification of the posterior longitudinal ligament: a minimum 10-year cohort study. J Neurosurg 100(3 Suppl Spine):245–248
Benneker LM, Heini PF, Anderson SE, Alini M, Ito K (2005) Correlation of radiographic and MRI parameters to morphological and biochemical assessment of intervertebral disc degeneration. Eur Spine J 14(1):27–35
Rodriguez DP, Poussaint TY (2010) Imaging of back pain in children. AJNR Am J Neuroradiol 31(5):787–802
Sieron D, Gruszczynska K, Machnikowska-Sokolowska M, Olczak Z, Knap D, Baron J (2013) Intervertebral disc calcification in children: case description and review of relevant literature. Pol J Radiol 78(1):78–80
Dai LY, Ye H, Qian QR (2004) The natural history of cervical disc calcification in children. J Bone Joint Surg Am 86-A(7):1467–1472
Smith ZA, Buchanan CC, Raphael D, Khoo LT (2011) Ossification of the posterior longitudinal ligament: pathogenesis, management, and current surgical approaches. a review. Neurosurg Focus 30(3):E10
Iwasaki M, Okuda S, Miyauchi A, Sakaura H et al (2007) Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: part 2: advantages of anterior decompression and fusion over laminoplasty. Spine (Phila Pa 1976) 32(6):654–660
Compliance with ethical standards
This research was approved by the ethics committee of Central South University.
Conflict of interest
All authors declare no conflicts of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, G., Kang, Y., Chen, F. et al. Cervical intervertebral disc calcification combined with ossification of posterior longitudinal ligament in an-11-year old girl: case report and review of literature. Childs Nerv Syst 32, 381–386 (2016). https://doi.org/10.1007/s00381-015-2840-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00381-015-2840-1