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Efficacy, safety, and outcomes in 17 pediatric cases treated with the free radical scavenger edaravone

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Abstract

Subjects

Edaravone is a free radical scavenger with brain protection properties and is recommended by “The Japanese Guidelines for the Management of Stroke 2009” for administration to adult patients, in whom it has been shown to improve neurological deficits after cerebral infarction. However, its dosage and effects have not yet been established in children.

Methods

Seventeen pediatric patients with cerebral ischemia were administered edaravone at a dose based on body weight from the standard dose given to adults. Functional outcomes were evaluated using mRS and PSOM (modified ranking scale and pediatric stroke outcome scale, respectively).

Results

Immediate post-treatment results were mostly positive, with no liver or renal complications. In some cases, neurological symptoms markedly improved after the administration of edaravone.

Conclusions

The efficacy of edaravone has not yet been examined in pediatric patients. The results of the present study suggest that edaravone has potential in the treatment of children safely with promising results similar to those in adults.

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Acknowledgments

We thank Dr. Kostadin Karagiozov for his advice and manuscript review and David Huang for his guidance, and gratefully acknowledge the radiological technologists, nurses, and staff of the Department of Neurosurgery, Tokyo Women’s Medical University in preparing this manuscript.

Declaration of funding source

This study was supported by research funds from the Department of Neurosurgery, Tokyo Women’s Medical University.

Conflict of interest

The authors have no personal financial or institutional interest in any of the materials or devices described in this study. The authors have no conflicts of interest relevant to this study to disclose.

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Authors and Affiliations

  1. Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan

    Hidetoshi Nakamoto, Yasuo Aihara, Koji Yamaguchi, Takakazu Kawamata & Yoshikazu Okada

  2. Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University, 8-1 Kawada-cho Shinjuku-ku, Tokyo, 162-8666, Japan

    Yasuo Aihara

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  1. Hidetoshi Nakamoto
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  2. Yasuo Aihara
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  3. Koji Yamaguchi
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  4. Takakazu Kawamata
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  5. Yoshikazu Okada
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Corresponding author

Correspondence to Yasuo Aihara.

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Nakamoto, H., Aihara, Y., Yamaguchi, K. et al. Efficacy, safety, and outcomes in 17 pediatric cases treated with the free radical scavenger edaravone. Childs Nerv Syst 31, 1533–1540 (2015). https://doi.org/10.1007/s00381-015-2814-3

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  • DOI: https://doi.org/10.1007/s00381-015-2814-3

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