Skip to main content

Advertisement

Log in

Hypertrophic pachymeningitis

  • Case-Based Update
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Background

Hypertrophic pachymeningitis (HP) is a rare clinical entity characterized by diffuse or localized fibrous thickening of the dura mater. It is well known but rare especially in pediatric population disease of differing origins. The primary (idiopathic) form is diagnosed after excluding other possible etiologies. Similar results from magnetic resonance imaging (MRI) for patients with hypertrophic pachymeningitis and meningiomas may make the diagnosis confusing. Additionally, making a proper diagnosis without histological sampling can be difficult in some cases.

Case description

We present a case of an 18-year-old boy diagnosed with hypertrophic pachymeningitis in the area of the hypoglossal canal. The diagnosis was made after a 2-month history of hypoglossal nerve palsy and dysphagia preceded by a middle ear infection. The patient was treated surgically with suspicion of meningioma, but no evidence of a tumor was found during the operation. The postoperative period was uneventful. At the latest check-up, MRI revealed regression of all previously observed pathological changes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Bucy PC, Freeman LW (1952) Hypertrophic spinal pachymeningitis with special reference to appropriate surgical treatment. J Neurosurg 9:564–578

    Article  CAS  PubMed  Google Scholar 

  2. Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, Yamasaki R, Yoshida M, Kusunoki S, Sakata K, Fujii K, Kira J (2014) A nationwide survey of hypertrophic pachymeningitis in Japan. J Neurol Neurosurg Psychiatry 85:732–739

    Article  PubMed  Google Scholar 

  3. Lieberman AP (2007) Inflammatory dural masses: if it’s not one thing, it’s another. J Neuroophthalmol Off J N Am Neuroophthalmol Soc 27:89–90

    Article  Google Scholar 

  4. Guidetti B, La Torre E (1967) Hypertrophic spinal pachymeningitis. J Neurosurg 26:496–503

    Article  CAS  PubMed  Google Scholar 

  5. Mikawa Y, Watanabe R, Hino Y, Hirano K (1994) Hypertrophic spinal pachymeningitis. Spine 19:620–625

    Article  CAS  PubMed  Google Scholar 

  6. Hassan KM, Deb P, Bhatoe HS (2011) Idiopathic hypertrophic cranial pachymeningitis: three biopsy-proven cases including one case with abdominal pseudotumor and review of the literature. Ann Indian Acad Neurol 14:189–193

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Rudnik A, Larysz D, Gamrot J, Rudnik A, Skorupa A, Bierzynska-Macyszyn G, Bazowski P (2007) Idiopathic hypertrophic pachymeningitis—case report and literature review. Folia Neuropathol Assoc Pol Neuropathol Med Res Cent Pol Acad Sci 45:36–42

    Google Scholar 

  8. Sharma PK, Saikia B, Sharma R, Gagneja V, Khilnani P (2014) Pachymeningitis in a young child responded to antitubercular therapy: a case report. J Child Neurol 29:92–95

    Article  Google Scholar 

  9. Aburahma SK, Anabtawi AG, Al Rimawi HS, Elheis MA, Mohtaseb AH (2009) Idiopathic hypertrophic pachymeningitis in a child with hydrocephalus. Pediatr Neurol 40:457–460

    Article  PubMed  Google Scholar 

  10. Asano T, Hayashida M, Ogawa K, Adachi K, Teramoto A, Yamamoto M (1998) Hypertrophic cranial pachymeningitis in a patient with aplastic anemia. Ann Hematol 77:279–282

    Article  CAS  PubMed  Google Scholar 

  11. van Toorn R, Esser M, Smit D, Andronikou S (2008) Idiopathic hypertrophic cranial pachymeningitis causing progressive polyneuropathies in a child. Eur J Paediatr Neurol Off J Eur Paediatr Neurol Soc 12:144–147

    Article  Google Scholar 

  12. Karimi A, Tabatabaei SR, Shiva F, Sayfikar M, Jafari M, Shirvani F, Shiari R Tuberculous pachymeningitis in a young child with spinal involvement: a case report. International J Infect Dis 21: 419

  13. Wattamwar PR, Doshi SA, Thomas B, Nair M, Kuruvilla A (2012) Hypertrophic pachymeningitis in a patient with Takayasu arteritis: one more association? Ann Indian Acad Neurol 15:56–59

    Article  PubMed Central  PubMed  Google Scholar 

  14. Gupta V, Sharma AK, Sureka RK, Bhuyan SK, Singh PK (2013) Chronic meningitis with multiple cranial neuropathies: a rare initial presentation of Wegener’s granulomatosis. Ann Indian Acad Neurol 16:411–413

    Article  PubMed Central  PubMed  Google Scholar 

  15. Vale TC, Duani H, Macedo DL, Christo PP (2013) Cranial hypertrophic pachymeningitis secondary to neurocysticercosis. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol 34:401–403

    Google Scholar 

  16. Vale TC, Moraes TE, Lara A, Cota GF, Christo PP (2012) Hypertrophic cervical spinal cord pachymeningitis due to Treponema pallidum infection. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol 33:359–362

    Google Scholar 

  17. Okuma H, Kobori S, Shinohara Y, Takagi S (2007) A case of hypertrophic pachymeningitis with prolonged headache, attributable to Epstein-Barr virus. Headache 47:620–622

    Article  PubMed  Google Scholar 

  18. Kato H, Nakajima M, Ichikawa H, Kawamura M (2011) Hypertrophic pachymeningitis in an immunocompetent adult with positive Aspergillus DNA in the cerebrospinal fluid. Neurol India 59:111–113

    Article  PubMed  Google Scholar 

  19. Ismail AR, Clifford L, Meacock WR (2007) Compressive optic neuropathy in fungal hypertrophic cranial pachymeningitis. Eye (Lond) 21:568–569

    Article  CAS  Google Scholar 

  20. Shobha N, Mahadevan A, Taly AB, Sinha S, Srikanth SG, Satish S, Nandagopal R, Arunodaya GR, Chandramouli BA, Shankar SK (2008) Hypertrophic cranial pachymeningitis in countries endemic for tuberculosis: diagnostic and therapeutic dilemmas. J Clin Neurosci Off J Neurosurg Soc Australas 15:418–427

    CAS  Google Scholar 

  21. Senapati SB, Mishra SS, Das S, Parida DK, Satapathy MC (2014) Cranio cervical tuberculous hypertrophic pachymeningitis. Surg Neurol Int 5:52

    Article  PubMed Central  PubMed  Google Scholar 

  22. Iwasaki S, Ito K, Sugasawa M (2006) Hypertrophic cranial pachymeningitis associated with middle ear inflammation. Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 27:928–933

    Article  Google Scholar 

  23. Dickson G (2014) Acute otitis media. Prim Care 41:11–18

    Article  PubMed  Google Scholar 

  24. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K (2001) High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 344:732–738

    Article  CAS  PubMed  Google Scholar 

  25. Utsuki S, Kijima C, Fujii K, Miyakawa S, Iizuka T, Hara A (2013) Investigation of IgG4-positive cell infiltration in biopsy specimens from cases of hypertrophic pachymeningitis. Clin Neuropathol 32:84–90

    Article  PubMed  Google Scholar 

  26. Lee YS, Lee HW, Park KS, Park SH, Hwang JH (2014) Immunoglobulin G4-related hypertrophic pachymeningitis with skull involvement. Brain Tumor Res Treat 2:87–91

    Article  PubMed Central  PubMed  Google Scholar 

  27. Liao B, Kamiya-Matsuoka C, Fang X, Smith RG (2014) Refractory IgG4-related intracranial hypertrophic pachymeningitis responded to rituximab. Neurol Neuroimmunol Neuroinflammation 1:e41

    Article  Google Scholar 

  28. Takeuchi S, Osada H, Seno S, Nawashiro H (2014) IgG4-related intracranial hypertrophic pachymeningitis: a case report and review of the literature. J Korean Neurosur Soc 55:300–302

    Article  Google Scholar 

  29. Lu LX, Della-Torre E, Stone JH, Clark SW (2014) IgG4-related hypertrophic pachymeningitis: clinical features, diagnostic criteria, and treatment. JAMA Neurol 71:785–793

    Article  PubMed  Google Scholar 

  30. Mehta SH, Switzer JA, Biddinger P, Rojiani AM (2014) IgG4-related leptomeningitis: a reversible cause of rapidly progressive cognitive decline. Neurology 82:540–542

    Article  PubMed  Google Scholar 

  31. Wallace ZS, Carruthers MN, Khosroshahi A, Carruthers R, Shinagare S, Stemmer-Rachamimov A, Deshpande V, Stone JH (2013) IgG4-related disease and hypertrophic pachymeningitis. Medicine 92:206–216

    Article  CAS  PubMed  Google Scholar 

  32. Yamashita H, Takahashi Y, Ishiura H, Kano T, Kaneko H, Mimori A (2012) Hypertrophic pachymeningitis and tracheobronchial stenosis in IgG4-related disease: case presentation and literature review. Intern Med (Tokyo, Jpn) 51:935–941

    Article  Google Scholar 

  33. Della-Torre E, Galli L, Franciotta D, Bozzolo EP, Briani C, Furlan R, Roveri L, Sessa M, Passerini G, Sabbadini MG (2014) Diagnostic value of IgG4 Indices in IgG4-related hypertrophic pachymeningitis. J Neuroimmunol 266:82–86

    Article  CAS  PubMed  Google Scholar 

  34. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H (2012) Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol Japan Rheum Assoc 22:21–30

    Article  CAS  Google Scholar 

  35. Iguchi A, Wada Y, Kobayashi D, Sato H, Oyama T, Nakatsue T, Murakami S, Kuroda T, Nakano M, Narita I (2013) A case of MPO- and PR3-ANCA-positive hypertrophic cranial pachymeningitis with elevated serum IgG4. Mod Rheumatol Japan Rheum Assoc 23:151–155

    Article  Google Scholar 

  36. Zhou Z, Li Q, Zheng J (2010) Hypertrophic cranial pachymeningitis induced by long-term administration of nonsteroidal antiinflammatory drugs. Ann Pharmacother 44:755–759

    Article  PubMed  Google Scholar 

  37. Ahmed M, Luggen M, Herman JH, Weiss KL, Decourten-Myers G, Quinlan JG, Khanna D (2006) Hypertrophic pachymeningitis in rheumatoid arthritis after adalimumab administration. J Rheumatol 33:2344–2346

    CAS  PubMed  Google Scholar 

  38. Togashi M, Komatsuda A, Masai R, Maki N, Hatakeyama T, Wakui H, Sawada K (2008) Hypertrophic cranial pachymeningitis in a patient with Cogan’s syndrome. Clin Rheumatol 27(Suppl 1):S33–S35

    Article  PubMed  Google Scholar 

  39. Yunokawa K, Hagiyama Y, Mochizuki Y, Tanaka N, Ochi M (2007) Hypertrophic spinal pachymeningitis associated with heavy-chain disease. Case report. J Neurosurg Spine 7:459–462

    Article  PubMed  Google Scholar 

  40. Voller B, Vass K, Wanschitz J, Machold K, Asenbaum S, Hoberstorfer M, Auff E (2001) Hypertrophic chronic pachymeningitis as a localized immune process in the craniocervical region. Neurology 56:107–109

    Article  CAS  PubMed  Google Scholar 

  41. Botella C, Orozco M, Navarro J, Riesgo P (1994) Idiopathic chronic hypertrophic craniocervical pachymeningitis: case report. Neurosurgery 35:1144–1149

    Article  CAS  PubMed  Google Scholar 

  42. Matsumoto K, Natori Y, Hirokawa E, Iwaki T (2002) Hypertrophic pachymeningitis as a result of a retropharyngeal inflammatory pseudotumor: case report. Neurosurgery 51:1061–1064, discussion 1064–1065

    PubMed  Google Scholar 

  43. Cannon PS, Cruz AA, Pinto CT, Mastropietro DA, Chahud F, Bilyk JR, Selva D, Prabhakaran VC (2011) A multi-centre case series investigating the aetiology of hypertrophic pachymeningitis with orbital inflammation. Orbit (Amsterdam, Neth) 30:64–69

    Google Scholar 

  44. Roongpiboonsopit D, Phanthumchinda K (2014) Idiopathic hypertrophic pachymeningitis at King Chulalongkorn Memorial Hospital. J Med Assoc Thai 97:374–380

    PubMed  Google Scholar 

  45. Saito T, Fujimori J, Yoshida S, Kaneko K, Kodera T (2014) Case of cerebral venous thrombosis caused by MPO-ANCA associated hypertrophic pachymeningitis. Clin Neurol (Rinsho Shinkeigaku) 54:827–830

    Article  Google Scholar 

  46. Xia Z, Chen-Plotkin A, Schmahmann JD (2010) Hypertrophic pachymeningitis and cerebral venous sinus thrombosis in inflammatory bowel disease. J Clin Neurosci Off J Neurosurg Soc Australas 17:1454–1456

    Google Scholar 

  47. Bhatia R, Tripathi M, Srivastava A, Garg A, Singh MB, Nanda A, Padma MV, Prasad K (2009) Idiopathic hypertrophic cranial pachymeningitis and dural sinus occlusion: two patients with long-term follow up. J Clin Neurosci Off J Neurosurg Soc Australas 16:937–942

    CAS  Google Scholar 

  48. Oiwa Y, Hyotani G, Kamei I, Itakura T (2004) Idiopathic hypertrophic cranial pachymeningitis associated with total occlusion of the dural sinuses—case report. Neurol Med Chir 44:650–654

    Article  Google Scholar 

  49. Tanboon J, Felicella MM, Bilbao J, Mainprize T, Perry A (2013) Probable IgG4-related pachymeningitis: a case with transverse sinus obliteration. Clin Neuropathol 32:291–297

    Article  PubMed  Google Scholar 

  50. Wang YJ, Fuh JL, Lirng JF, Lu SR, Wang SJ (2004) Headache profile in patients with idiopathic hypertrophic cranial pachymeningitis. Headache 44:916–923

    Article  PubMed  Google Scholar 

  51. Wouda EJ, Vanneste JA (1998) Aspecific headache during 13 years as the only symptom of idiopathic hypertrophic pachymeningitis. J Neurol Neurosurg Psychiatry 64:408–409

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  52. Im SH, Cho KT, Seo HS, Choi JS (2008) Idiopathic hypertrophic cranial pachymeningitis presenting with headache. Headache 48:1232–1235

    Article  PubMed  Google Scholar 

  53. Chan JW (2012) Short-lasting unilateral neuralgiform headache with autonomic symptoms syndrome as the initial manifestation of idiopathic hypertrophic cranial pachymeningitis. Headache 52:149–152

    Article  PubMed  Google Scholar 

  54. Singh C, Kesavadas C, Nair MD, Sarada C (2009) Acquired anterior basal encephalocele in idiopathic hypertrophic pachymeningitis. Neuroradiol J 21:791–794

    Article  CAS  PubMed  Google Scholar 

  55. Hamada J, Yoshinaga Y, Korogi Y, Ushio Y (2000) Idiopathic hypertrophic cranial pachymeningitis associated with a dural arteriovenous fistula involving the straight sinus: case report. Neurosurgery 47:1230–1233

    Article  CAS  PubMed  Google Scholar 

  56. Jose A, Nagori SA, Bhutia O, Roychoudhury A (2014) Odontogenic infection and pachymeningitis of the cavernous sinus. Br J Oral Maxillofac Surg 52:e27–e29

    Article  PubMed  Google Scholar 

  57. Terada K, Misu N, Nara Y (1998) Painful ophthalmoplegia caused by idiopathic hypertrophic cranial pachymeningitis in the cavernous sinus. J Clin Neurosci Off J Neurosurg Soc Australas 5:363–365

    CAS  Google Scholar 

  58. Muthukumar N, Senthilbabu S, Usharani K (2005) Idiopathic hypertrophic cranial pachymeningitis masquerading as Tolosa-Hunt syndrome. J Clin Neurosci Off J Neurosurg Soc Australas 12:589–592

    CAS  Google Scholar 

  59. Nakamagoe K, Hosaka A, Kondo Y, Ishikawa E, Tamaoka A (2010) A case of idiopathic hypertrophic cranial pachymeningitis presenting high values of matrix metalloproteinase. BMJ case reports 2010

  60. Liewluck T, Schatz NJ, Potter PF, Romaguera RL (2008) Compressive retrobulbar optic neuropathy due to hypertrophic pachymeningitis. Intern Med (Tokyo, Jpn) 47:1761–1762

    Article  Google Scholar 

  61. Suresh CT, Devi V, Muralikrishna MM (2013) Hypertrophic tumefactive pachymeningitis presenting as left visual loss. J Assoc Physicians India 61:563–564

    CAS  PubMed  Google Scholar 

  62. Weir NU, Collie D, McIlwaine GG, Lueck CJ (1999) Idiopathic hypertrophic chronic pachymeningitis presenting with acute visual loss. Eye (Lond Engl) 13(Pt 3a):384–387

    Article  Google Scholar 

  63. Shintani S, Shiigai T, Tsuruoka S (1993) Hypertrophic cranial pachymeningitis causing progressive unilateral blindness: MR findings. Clin Neurol Neurosurg 95:65–70

    Article  CAS  PubMed  Google Scholar 

  64. Mathew RG, Hogarth KM, Coombes A (2012) Idiopathic hypertrophic cranial pachymeningitis presenting as acute painless visual loss. Int Ophthalmol 32:195–197

    Article  PubMed  Google Scholar 

  65. Iwasaki S, Matsui Y, Ito K, Naito R, Abbey K (2003) Hypertrophic cranial pachymeningitis presenting as steroid-responsive hearing loss. Ann Otol Rhinol Laryngol 112:476–479

    Article  PubMed  Google Scholar 

  66. Lim EJ, Kim SH, Lee SH, Lee KY, Choi JH, Nam EJ, Lee SH (2011) Reversible sensorineural hearing loss due to pachymeningitis associated with elevated serum MPO-ANCA. Clin Exp Otorhinolaryngol 4:155–158

    Article  PubMed Central  PubMed  Google Scholar 

  67. Bovo R, Berto A, Palma S, Ceruti S, Martini A (2007) Symmetric sensorineural progressive hearing loss from chronic idiopathic pachymeningitis. Int J Audiol 46:107–110

    Article  PubMed  Google Scholar 

  68. Tan K, Lim SA, Thomas A, Lim CT, Wong SY, Tan CB (2008) Idiopathic hypertrophic pachymeningitis causing seizures. Eur J Neurol Off J Eur Fed Neurol Soci 15:e12–e13

    CAS  Google Scholar 

  69. Lv RJ, Cui T, Ma YT, Zhou H, Zhang XH, Shao XQ (2014) Somatosensory reflex seizures in a patient with hypertrophic cranial pachymeningitis. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol 35:777–780

    Google Scholar 

  70. Kim EH, Kim SH, Cho JM, Ahn JY, Chang JH (2011) Immunoglobulin G4-related hypertrophic pachymeningitis involving cerebral parenchyma. J Neurosurg 115:1242–1247

    Article  PubMed  Google Scholar 

  71. Tuncel D, Yucesan C, Erden E, Savas A, Erden I, Mutluer N (2005) Idiopathic hypertrophic cranial pachymeningitis with perifocal brain edema. Clin Neurol Neurosurg 107:249–252

    Article  PubMed  Google Scholar 

  72. Nakazaki H, Tanaka T, Isoshima A, Hida T, Nakajima M, Abe T (2000) Idiopathic hypertrophic cranial pachymeningitis with perifocal brain edema—case report. Neurol Med Chir 40:239–243

    Article  CAS  Google Scholar 

  73. Ito F, Kondo N, Fukushima S, Suzuki K, Awata S, Matsuoka H (2010) Catatonia induced by idiopathic hypertrophic pachymeningitis. Gen Hosp Psychiatry 32:447, e447–447.e410

    Article  PubMed  Google Scholar 

  74. Yamakita N, Hanamoto T, Muraoka N, Ikeda T, Hirata T, Yasuda K, Sano T (2004) Hypopituitarism and diabetes insipidus with localized hypertrophic pachymeningitis (Tolosa-Hunt syndrome) associated with Hashimoto thyroiditis. Am J Med Sci 327:38–43

    Article  PubMed  Google Scholar 

  75. Skierczynski PA, Goodman JM, Signal P, Payner TD, Bonnin JM (2007) Idiopathic hypertrophic pachymeningitis resulting in delayed panhypopituitarism. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinologist 13:481–486

    Google Scholar 

  76. Kitai R, Sato K, Kubota T, Kabuto M, Uno H, Kobayashi H (1997) Hypertrophic cranial pachymeningitis involving the pituitary gland: a case report. Surg Neurol 48:58–62, discussion 62–53

    Article  CAS  PubMed  Google Scholar 

  77. Park SH, Whang CJ, Sohn M, Oh YC, Lee CH, Whang YJ (2001) Idiopathic hypertrophic spinal pachymeningitis: a case report. J Korean Med Sci 16:683–688

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  78. Khadilkar SV, Menezes K, Parekh HN, Ursekar M, Bhagwati SN (2003) Idiopathic hypertrophic cervical pachymeningitis: a case report with 5 year follow up. J Assoc Physicians India 51:391–393

    CAS  PubMed  Google Scholar 

  79. Jee TK, Lee SH, Kim ES, Eoh W (2014) Idiopathic hypertrophic spinal pachymeningitis with an osteolytic lesion. J Korean Neurosurg Soci 56:162–165

    Article  Google Scholar 

  80. Ashkenazi E, Constantini S, Pappo O, Gomori M, Averbuch-Heller L, Umansky F (1991) Hypertrophic spinal pachymeningitis: report of two cases and review of the literature. Neurosurgery 28:730–732

    Article  CAS  PubMed  Google Scholar 

  81. Kanamori M, Matsui H, Terahata N, Tsuji H (1997) Hypertrophic spinal pachymeningitis. A case report. Spine 22:1787–1790

    Article  CAS  PubMed  Google Scholar 

  82. Kim JH, Park YM, Chin DK (2011) Idiopathic hypertrophic spinal pachymeningitis: report of two cases and review of the literature. J Korean Neurosurg Soc 50:392–395

    Article  PubMed Central  PubMed  Google Scholar 

  83. Ranasinghe MG, Zalatimo O, Rizk E, Specht CS, Reiter GT, Harbaugh RE, Sheehan J (2011) Idiopathic hypertrophic spinal pachymeningitis. J Neurosurg Spine 15:195–201

    Article  PubMed  Google Scholar 

  84. Takahashi H, Wada A, Yokoyama Y, Ishii M, Shibuya K, Suguro T (2010) Idiopathic hypertrophic spinal pachymeningitis: a case report. J Orthop Surg (Hong Kong) 18:113–117

    Google Scholar 

  85. Pai S, Welsh CT, Patel S, Rumboldt Z (2007) Idiopathic hypertrophic spinal pachymeningitis: report of two cases with typical MR imaging findings. AJNR Am J Neuroradiol 28:590–592

    Article  CAS  PubMed  Google Scholar 

  86. Rosenfeld JV, Kaye AH, Davis S, Gonzales M (1987) Pachymeningitis cervicalis hypertrophica. Case report. J Neurosurg 66:137–139

    Article  CAS  PubMed  Google Scholar 

  87. Smucker JD, Ramme AJ, Leblond RF, Bruch LA, Bakhshandehpour G (2011) Hypertrophic spinal pachymeningitis with thoracic myelopathy: the initial presentation of ANCA-related systemic vasculitis. J Spinal Disord Tech 24:525–532

    PubMed  Google Scholar 

  88. Mehta A, Duggal R, Nema SK (2006) Hypertrophic spinal pachymeningitis presenting as compressive myelopathy: a case report. Indian J Pathol Microbiol 49:286–288

    PubMed  Google Scholar 

  89. Sridhar K, Vasudevan MC (2004) Idiopathic chronic hypertrophic pachymeningitis causing thoracic cord compression. Br J Neurosurg 18:515–517

    Article  CAS  PubMed  Google Scholar 

  90. Pelz D, Heckmann JG, Oberst G (2014) Peace sign in calcified idiopathic hypertrophic pachymeningitis. Can J Neurol Sci 41:265–266

    Article  PubMed  Google Scholar 

  91. Thomas B, Thamburaj K, Kesavadas C (2007) ‘Eiffel-by-Night’: a new MR sign demonstrating reactivation in idiopathic hypertrophic pachymeningitis. Neuroradiol J 20:194–195

    Article  CAS  PubMed  Google Scholar 

  92. Lin CK, Lai DM (2013) IgG4-related intracranial hypertrophic pachymeningitis with skull hyperostosis: a case report. BMC Surg 13:37

    Article  PubMed Central  PubMed  Google Scholar 

  93. Keshavaraj A, Gamage R, Jayaweera G, Gooneratne IK (2012) Idiopathic hypertrophic pachymeningitis presenting with a superficial soft tissue mass. J Neurosci Rural Pract 3:193–195

    Article  PubMed Central  PubMed  Google Scholar 

  94. Hosler MR, Turbin RE, Cho ES, Wolansky LJ, Frohman LP (2007) Idiopathic hypertrophic pachymeningitis mimicking lymphoplasmacyte-rich meningioma. J Neuroophthalmol Off J N Am Neuroophthalmol Soc 27:95–98

    Article  Google Scholar 

  95. Deprez M, Born J, Hauwaert C, Otto B, Reznik M (1997) Idiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature. Acta Neuropathol 94:385–389

    Article  CAS  PubMed  Google Scholar 

  96. Roche JC, Sanchez-Carteyron A, Minchole E, Ara JR, Alarcia R (2012) Reply: idiopathic hypertrophic pachymeningitis mimicking neurosarcoidosis. Clin Neurol Neurosurg 114:825–826

    Article  PubMed  Google Scholar 

  97. Christakis PG, Machado DG, Fattahi P (2012) Idiopathic hypertrophic pachymeningitis mimicking neurosarcoidosis. Clin Neurol Neurosurg 114:176–178

    Article  PubMed  Google Scholar 

  98. Ishiyama K, Okada M, Anzai N, Tashima M (2011) Mantle cell lymphoma manifesting neurological symptoms similar to those of hypertrophic cranial pachymeningitis. [Rinsho ketsueki] Jpn J Clin Hematol 52:1788–1793

    Google Scholar 

  99. Park IS, Kim H, Chung EY, Cho KW (2010) Idiopathic hypertrophic cranial pachymeningitis misdiagnosed as acute subtentorial hematoma. J Korean Neurosurg Soc 48:181–184

    Article  PubMed Central  PubMed  Google Scholar 

  100. Hirunwiwatkul P, Trobe JD, Blaivas M (2007) Lymphoplasmacyte-rich meningioma mimicking idiopathic hypertrophic pachymeningitis. J Neuroophthalmol Off J N Am Neuroophthalmol Soc 27:91–94

    Article  Google Scholar 

  101. Singh P, Verma R, Paliwal VK, Neyaz Z (2012) Neuroblastoma presenting as hypertrophic pachymeningitis in a young female. Neurol India 60:655–656

    Article  PubMed  Google Scholar 

  102. Norikane T, Yamamoto Y, Okada M, Maeda Y, Aga F, Kawai N, Nishiyama Y (2012) Hypertrophic cranial pachymeningitis with IgG4-positive plasma cells detected by C-11 methionine PET. Clin Nucl Med 37:108–109

    Article  PubMed  Google Scholar 

  103. Nishio S, Morioka T, Togawa A, Yanase T, Nawata H, Fukui M, Hasuo K (1995) Spontaneous resolution of hypertrophic cranial pachymeningitis. Neurosurg Rev 18:201–204

    Article  CAS  PubMed  Google Scholar 

  104. Karakasis C, Deretzi G, Rudolf J, Tsiptsios I (2012) Long-term lack of progression after initial treatment of idiopathic hypertrophic pachymeningitis. J Clin Neurosci Off J Neurosurg Soc Australas 19:321–323

    Google Scholar 

  105. Tsutsui M, Yasuda T, Kanamori M, Hori T, Kimura T (2012) Long-term outcome of idiopathic hypertrophic thoracic pachymeningitis. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc 21(Suppl 4):S404–S407

    Article  Google Scholar 

  106. Denays R, Milbouw G, Mosseray A, Michotte A, Hella P (2013) Focal idiopathic hypertrophic pachymeningitis: a case with two separate sites involved at a 5-year interval. Acta Neurol Belg 113:95–98

    Article  PubMed  Google Scholar 

  107. Ito Z, Osawa Y, Matsuyama Y, Aoki T, Harada A, Ishiguro N (2006) Recurrence of hypertrophic spinal pachymeningitis. Report of two cases and review of the literature. J Neurosurg Spine 4:509–513

    Article  PubMed  Google Scholar 

  108. Claus E, Rutgers M, Sindic C, Raftopoulos C, Godfraind C, Duprez T (2005) Remitting/relapsing idiopathic hypertrophic spinal pachymeningitidis: comprehensive imaging work-up and MR monitoring. Eur Radiol 15:53–58

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tomasz Dziedzic.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dziedzic, T., Wojciechowski, J., Nowak, A. et al. Hypertrophic pachymeningitis. Childs Nerv Syst 31, 1025–1031 (2015). https://doi.org/10.1007/s00381-015-2680-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-015-2680-z

Keywords

Navigation