Abstract
Purpose
The aim of this study is to elucidate the architecture of these fine structures in human fetuses.
Methods
The histological examination of medial wall (MW) and lateral wall (LW) was performed in 15 normal human fetuses. Eleven fetuses were female and four were male. The gestational age ranged between 14 and 35 weeks. The weight ranged between 180 and 1750 g. The wall samples (two MW and two LW from each fetus) were obtained by microsurgical technique and underwent histological examination. Each wall was examined for the structure and composition of collagen and elastic fibers, ganglions, peripheral nerves, and vessels.
Results
A total of 60 wall samples (30 MW and 30 LW) were examined in 15 fetuses. Loose connective tissue composed of type III collagen was observed in both of the walls. Elastic fibers were observed only in three wall samples (two MW and one LW). Ganglion was detected in 11 samples (nine in LW and two in MW), and peripheral nerve was found in 28 walls (18 LW and 10 MW). Vessels were observed in 51 samples (26 LW and 25 MW). None of the walls was stained with type I collagen.
Conclusions
The structure of LW and MW of the cavernous sinus (CS) in fetuses is mainly composed of collagen tissue while some elastic fibers are supported by this tissue. Type III collagen is the main component of fetal CS walls. Because of the weak histological structure, CS may be more prone to tumor invasion in infants.
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References
Bergman RA, Afifi AK, Heidger PM (2013) Connective tissue. Atlas of microscopic anatomy. Anatomy Atlases. Curated by Bergman RA. Available at http://www.anatomyatlases.org. Accessed 12 Sept 2013
Campero A, Campero AA, Martins C, Yasuda A, Rhoton AL Jr (2010) Surgical anatomy of the dural walls of the cavernous sinus. J Clin Neurosci 17(6):746–750
Cottier JP, Destrieux C, Brunereau L, Bertrand P, Moreau L, Jan M, Herbreteau D (2000) Cavernous sinus invasion by pituitary adenoma: MR imaging. Radiology 215(2):463–469
Diao Y, Liang L, Yu C, Zhang M (2013) Is there an identifiable intact medial wall of the cavernous sinus? Macro- and microscopic anatomical study using sheet plastination. Neurosurgery 73(1 Suppl Operative) ons106–110
Dietemann JL, Kehrli P, Maillot C, Diniz R, Reis M Jr, Neugroschl C, Vinclair L (1998) Is there a dural wall between the cavernous sinus and the pituitary fossa? Anatomical and MRI findings. Neuroradiology 40:627–630
Dolenc VV (1989) Relation of the cavernous sinus to the sella. In: Dolenc VV (ed) Anatomy and surgery of the cavernous sinus. Springer-Verlag, Wien, pp 118–130
Gonçalves MB, de Oliveira JG, Williams HA, Alvarenga RM, Landeiro JA (2012) Cavernous sinus medial wall: dural or fibrous layer? Systematic review of the literature. Neurosurg Rev 35(2):147–153
Gray H (1995) Angiologia. In: Williams PL, Warwick R, Dyson M, Bannister LH (eds) Gray anatomia, vol 1. Guanabara Koogan, Rio de Janerio, pp 754–755
Haines DE, Harkey HL, Al-Mefty O (1993) The “subdural” space: a new look at an outdated concept. Neurosurgery 32:111–120
Harris FS, Rhoton AL Jr (1976) Anatomy of the cavernous sinus. J Neurosurg 45:169–180
Hashimoto M, Yokota A, Yamada H, Okudera T (2000) Development of the cavernous sinus in the fetal period: a morphological study. Neurol Med Chir (Tokyo) 40(3):140–150
Kehrli P, Ali M, Reis M Jr, Maillot C, Dietemann JL, Dujovny M, Ausman JI (1998) Anatomy and embryology of the lateral sellar compartment (cavernous sinus) medial wall. Neurol Res 20:585–592
Kırıcı Y, Kılıc C, Kocaoglu M, Ozan H (2010) Radiological and anatomical evaluation of the cranial nerves running lateral wall of the cavernous sinus. Gulhane Med J 52:162–166
Knappe UJ, Konerding MA, Schoenmayr R (2009) Medial wall of the cavernous sinus: microanatomical diaphanoscopic and episcopic investigation. Acta Neurochir (Wien) 151(8):961–967
Marinkovic S, Gibo H, Vucevic R, Petrovic P (2001) Anatomy of the cavernous sinus region. J Clin Neurosci 8(Suppl 1):78–81
Parkinson D (1995) Lateral sellar compartment. History and anatomy. J Craniofac Surg 6:55–68
Peker S, Kurtkaya-Yapicier O, Kilic T, Pamir MN (2005) Microsurgical anatomy of the lateral walls of the pituitary fossa. Acta Neurochir (Wien) 147(6):641–648
Rhoton AL Jr (2002) The cavernous sinus, the cavernous venous plexus, and the carotid collar. Neurosurgery 51(Suppl 1):375–410
Tobenas-Dujardin AC, Duparc F, Ali N, Laquerriere A, Muller JM, Freger P (2005) Embryology of the internal carotid artery dural crossing: apropos of a continuous series of 48 specimens. Surg Radiol Anat 27(6):495–501
Umansky F, Nathan H (1982) The lateral wall of the cavernous sinus. J Neurosurg 56:228–234
Winslow JB (1734) Exposition anatomique de la structure du corps humain. N. Prevast, London, Vol II, pp 29
Yasuda A, Campero A, Martins C, Rhoton AL Jr, Ribas GC (2004) The medial wall of the cavernous sinus: an anatomical study. Neurosurgery 55:179–190
Yılmazlar S, Kocaeli H, Aydiner F, Korfali E (2005) Medial portion of the cavernous sinus: quantitative analysis of the medial wall. Clin Anat 18(6):416–422
Yokoyama S, Hirano H, Moroki K, Goto M, Imamura S, Kuratsu JI (2001) Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery 49(4):857–862
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Kural, C., Simsek, G.G., Guresci, S. et al. Histological structure of the medial and lateral walls of cavernous sinus in human fetuses. Childs Nerv Syst 31, 699–703 (2015). https://doi.org/10.1007/s00381-015-2644-3
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DOI: https://doi.org/10.1007/s00381-015-2644-3