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Pediatric de novo cerebral AVM: report of two cases and review of literature

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Abstract

Purpose

Cerebral arteriovenous malformation (AVM) is traditionally thought of as a congenital diagnosis. In recent years, there has been infrequent reports of this neurovascular condition presenting as de novo entities.

Methods

The authors report two cases of pediatric patients who present with de novo cerebral AVMs. In both cases, the patients had magnetic resonance imaging (MRI) of the brain done as part of the work-up for first-onset seizures. At that point in time, the scans were unremarkable. After a latent period of approximately 6 and 9 years respectively, a repeated MRI brain scan showed evidence of de novo AVM for each patient.

Results

Both patients did not have radiological evidence of cerebral AVM during their first presentation of seizures. However, a repeated MRI brain scan after a period of 6 and 9 years demonstrated new findings of cerebral AVM for each patient.

Conclusions

Currently, the disease of cerebral de novo AVM remain as an ambiguous condition that is poorly understood. With the advances in molecular diagnostics, there are possibilities of exploring biochemical profiles for better understanding of the origin of cerebral AVMs. However, in the meantime, owing to the unpredictable nature of cerebral AVMs, clinicians should have increased awareness of this unique condition. This is especially important, as definitive treatment is available to prevent devastating neurological sequelae from cerebral AVM rupture.

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Conflict of interest

We, the authors of this manuscript, report no funding, financial support, or industrial affiliations received for the writing of this article. In addition, we report no conflict of interest concerning the material or methods used in this paper. This manuscript has not been published and is not being considered for publication elsewhere.

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Authors and Affiliations

  1. Faculty of Medicine, University of New South Wales, New South Wales, Australia

    Jared J. Y. Yeo

  2. Department of Neurosurgery, National Neuroscience Institute (Singapore), 11, Jalan Tan Tock Seng, Singapore, 308433, Singapore

    Sharon Y. Y. Low

  3. Neurosurgical Services, KK Women’s and Children’s Hospital, Singapore, Singapore

    Wan Tew Seow

  4. Neurosurgical Services, KK Women’s and Children’s Hospital, Singapore, Singapore

    David C. Y. Low

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  1. Jared J. Y. Yeo
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  2. Sharon Y. Y. Low
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Correspondence to Sharon Y. Y. Low.

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Yeo, J.J.Y., Low, S.Y.Y., Seow, W.T. et al. Pediatric de novo cerebral AVM: report of two cases and review of literature. Childs Nerv Syst 31, 609–614 (2015). https://doi.org/10.1007/s00381-014-2609-y

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  • DOI: https://doi.org/10.1007/s00381-014-2609-y

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