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Tract-based spatial statistics of diffusion tensor imaging after corpus callosotomy in relation to seizure recurrence

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Abstract

Purpose

To delineate microstructural changes in transected white matter tracts after corpus callosotomy in relation to seizure recurrence using tract-based spatial statistics of diffusion tensor imaging (DTI-TBSS).

Methods

We retrospectively included 12 total corpus callosotomy patients who had undergone serial pre- and postoperative DTI studies. The first postoperative DTI was performed within 6 months after callosotomy. The second postoperative DTI was performed in five patients with seizure recurrence (symptomatic group) and in seven patients without seizure recurrence (asymptomatic group) after 1 year following surgery. Group comparisons of fractional anisotropy (FA) with age- and sex-matched controls were performed in a whole brain voxel-wise manner using DTI-TBSS.

Results

The first postoperative DTI-TBSS showed a significant FA decrease in the entire corpus callosum in all patients. The second postoperative DTI-TBSS showed that a significant FA decrease remained in the entire corpus callosum in the asymptomatic group. However, in the symptomatic group, no significant decrease of FA was observed in some parts of the posterior body and splenium of the corpus callosum, although there was still a significant FA decrease in the genu of the corpus callosum.

Conclusions

Using DTI-TBSS analysis, we characterized and visualized microstructural white matter changes over time in relation to seizure recurrence in callosotomy patients, suggesting that reorganization of some transected white matter tracts may be related to seizure recurrence. DTI-TBSS analysis can provide reliable and useful information about the state of white matter bundles affected by corpus callosotomy in a noninvasive manner.

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Abbreviations

TBSS:

Tract-based spatial statistics

DTI:

Diffusion tensor imaging

FA:

Fractional anisotropy

MNI:

Montreal Neurological Institute

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Acknowledgements

This work was supported by the new faculty research fund of Ajou University School of Medicine.

Conflict of interest

The authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Pediatrics, Ajou University School of Medicine, Suwon, South Korea

    Da Eun Jung

  2. Department of Radiology and Research Institute of Radiology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, South Korea

    Woo Hyun Shim & Hee Mang Yoon

  3. Division of Pediatric Neurology, Pediatric Epilepsy Clinic, Department of Pediatrics, College of Medicine, Severance Children’s Hospital, Epilepsy Research Institute, Yonsei University, 134, Shinchon-dong, Seodaemun-gu, Seoul, South Korea

    Jeong A. Kim & Joon Soo Lee

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  1. Da Eun Jung
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  2. Woo Hyun Shim
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Correspondence to Joon Soo Lee.

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Jung, D.E., Shim, W.H., Yoon, H.M. et al. Tract-based spatial statistics of diffusion tensor imaging after corpus callosotomy in relation to seizure recurrence. Childs Nerv Syst 30, 2043–2049 (2014). https://doi.org/10.1007/s00381-014-2516-2

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  • DOI: https://doi.org/10.1007/s00381-014-2516-2

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