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Selective neuropsychological impairments and related clinical factors in children with moyamoya disease of the transient ischemic attack type

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Abstract

Purpose

Moyamoya disease is characterized by progressive narrowing of bilateral internal carotid arteries. Neuropsychological impairments are suspected due to frequent involvement of the frontotemporal areas. The present study thus aimed to investigate the pattern of neuropsychological function in children diagnosed with moyamoya disease.

Methods

Thirteen children with moyamoya disease of the transient ischemic attack type received standardized neuropsychological tests that evaluate general intellectual function, verbal comprehension, perceptual organization, working memory, processing speed, episodic memory, category fluency and visuospatial function. Related clinical factors were also analyzed.

Results

The results showed single-domain cognitive impairment in around 15 % of patients and multiple-domain cognitive impairments in 23 % of patients. Selective impairments of episodic memory and processing speed were especially noted in those with younger age of onset and prolonged symptom duration.

Conclusions

Neuropsychological impairments are not infrequent in children with moyamoya disease despite normal general intellectual functioning. The pattern of cognitive dysfunction is often associated with lesions in frontotemporal areas. Early detection and intervention shall be considered regarding cognitive outcome in pediatric group.

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Acknowledgments

This work was partially supported by the National Science Council of Taiwan (grant number NSC101-2321-b-182-014).

Author information

Authors and Affiliations

  1. Department of Psychology, College of Science, National Taiwan University, Number 1, Section 4, Roosevelt Road, Taipei 106, Taiwan

    Yen-Hsuan Hsu & Mau-Sun Hua

  2. Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, 8 Zhong-Shan South Road, Taipei 100, Taiwan

    Meng-Fai Kuo

  3. Departments of Psychiatry and Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, 8 Zhong-Shan South Road, Taipei 100, Taiwan

    Mau-Sun Hua

  4. Neurobiological and Cognitive Science Center, National Taiwan University, Number 1, Section 4, Roosevelt Road, Taipei 106, Taiwan

    Mau-Sun Hua

  5. Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, 8 Zhong-Shan South Road, Taipei 100, Taiwan

    Mau-Sun Hua

  6. Division of Clinical Psychology, Master of Behavioral Science, Department of Occupational Therapy, College of Medicine, Chang-Gung University, 259 Wenhua 1st Road, Taoyuan 333, Taiwan

    Chi-Cheng Yang

  7. Department of Neurology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Number 66, Section 1, Fongsing Road, Taichung 427, Taiwan

    Yen-Hsuan Hsu

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  1. Yen-Hsuan Hsu
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Correspondence to Chi-Cheng Yang.

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Hsu, YH., Kuo, MF., Hua, MS. et al. Selective neuropsychological impairments and related clinical factors in children with moyamoya disease of the transient ischemic attack type. Childs Nerv Syst 30, 441–447 (2014). https://doi.org/10.1007/s00381-013-2271-9

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  • DOI: https://doi.org/10.1007/s00381-013-2271-9

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