Skip to main content

Advertisement

SpringerLink
Log in

Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Purpose

John Cunningham (JC) viral DNA sequence has seldom been reported in patients with brain tumors such as high grade gliomas and medulloblastomas, pointing to a role in the etiopathogenesis of such tumors.

Results

We present a unique clinical case of an HIV-positive pediatric patient with multifocal leukoencephalopathy and confirmed JC virus (JCV) infection that developed a giant-cell glioblastoma.

Conclusions

Experimental data with infected primates has previously hypothesized an association of human giant-cell glioblastoma with JCV or progressive multifocal leukoencephalopathy, though such association has not been documented in the literature for humans. Future studies with larger cohorts and molecular pathological analyses are still needed to corroborate the role of the widely spread human neurotropic virus in early transformation and in the development of brain tumors with different histology in the setting of HIV-related severe immunosuppression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) (2007) WHO classification of tumours of the central nervous system. IARC, Lyon

    Google Scholar 

  2. Kozak KR, Moody JS (2009) Giant cell glioblastoma: a glioblastoma subtype with distinct epidemiology and superior prognosis. Neuro Oncol 11(6):833–841. doi:10.1215/15228517-2008-123

    Article  PubMed  Google Scholar 

  3. Pandey JP (2011) Genetic and viral etiology of glioblastoma—a unifying hypothesis. Cancer Epidemiol Biomark Prev 20(6):1061–1063

    Article  CAS  Google Scholar 

  4. Khalili K, Del Valle L, Otte J, Weaver M, Gordon J (2003) Human neurotropic polyomavirus, JCV, and its role in carcinogenesis. Oncogene 22(33):5181–5191. doi:10.1038/sj.onc.12065591206559

    Article  PubMed  CAS  Google Scholar 

  5. Piña-Oviedo S, De Leon-Bojorge B, Cuesta-Mejias T, White MK, Ortiz-Hidalgo C, Khalili K, Del Valle L (2006) Glioblastoma multiforme with small cell neuronal-like component: association with human neurotropic JC virus. Acta Neuropathol 111(4):388–396. doi:10.1007/s00401-006-0050-3

    Article  PubMed  Google Scholar 

  6. Noch E, Sariyer IK, Gordon J, Khalili K (2012) JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells. PLoS One 7(4):e35054

    Article  PubMed  CAS  Google Scholar 

  7. McNees AL, White ZS, Zanwar P, Vilchez RA, Butel JS (2005) Specific and quantitative detection of human polyomaviruses BKV, JCV, and SV40 by real time PCR. J Clin Virol 34(1):52–62

    Article  PubMed  CAS  Google Scholar 

  8. Walker DL, Padgett BL, ZuRhein GM, Albert AE, Marsh RF (1973) Human papovavirus (JC): induction of brain tumors in hamsters. Science 181(4100):674–676

    Article  PubMed  CAS  Google Scholar 

  9. London WT, Houff SA, Madden DL, Fuccillo DA, Gravell M, Wallen WC, Palmer AE, Sever JL, Padgett BL, Walker DL, ZuRhein GM, Ohashi T (1978) Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus). Science 201(4362):1246–1249

    Article  PubMed  CAS  Google Scholar 

  10. Neel JV, Major EO, Awa AA, Glover T, Burgess A, Traub R, Curfman B, Satoh C (1996) Hypothesis: "Rogue cell"-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncopenesis. Proc Natl Acad Sci U S A 93(7):2690–2695

    Article  PubMed  CAS  Google Scholar 

  11. Goel A, Li MS, Nagasaka T, Shin SK, Fuerst F, Ricciardiello L, Wasserman L, Boland CR (2006) Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers. Gastroenterology 130(7):1950–1961. doi:10.1053/j.gastro.2006.02.061

    Article  PubMed  CAS  Google Scholar 

  12. Del Valle L, Gordon J, Assimakopoulou M, Enam S, Geddes JF, Varakis JN, Katsetos CD, Croul S, Khalili K (2001) Detection of JC virus DNA sequences and expression of the viral regulatory protein T-antigen in tumors of the central nervous system. Cancer Res 61(10):4287–4293

    PubMed  Google Scholar 

  13. Blumenthal DT, Raizer JJ, Rosenblum MK, Bilsky MH, Hariharan S, Abrey LE (1999) Primary intracranial neoplasms in patients with HIV. Neurology 52(8):1648–1651

    Article  PubMed  CAS  Google Scholar 

  14. Hall JR, Short SC (2009) Management of glioblastoma multiforme in HIV patients: a case series and review of published studies. Clin Oncol (R Coll Radiol) 21(8):591–597. doi:10.1016/j.clon.2009.04.006

    Article  CAS  Google Scholar 

  15. Tada H, Rappaport J, Lashgari M, Amini S, Wong-Staal F, Khalili K (1990) Trans-activation of the JC virus late promoter by the tat protein of type 1 human immunodeficiency virus in glial cells. Proc Natl Acad Sci U S A 87(9):3479–3483

    Article  PubMed  CAS  Google Scholar 

  16. Krachmarov CP, Chepenik LG, Barr-Vagell S, Khalili K, Johnson EM (1996) Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha. Proc Natl Acad Sci U S A 93(24):14112–14117

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This study received financial support from the FAPESP (proc.: 2010/15717-0).

Author information

Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of SãoPaulo, SãoPaulo, Brazil

    María Sol Brassesco, Luiz Guilherme Darrigo Jr, Elvis Terci Valera, Yulie Aparecida Yamamoto & Luiz Gonzaga Tone

  2. Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of SãoPaulo, SãoPaulo, Brazil

    Ricardo Santos Oliveira

  3. Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of SãoPaulo, SãoPaulo, Brazil

    Marcus Vinícius de Castro Barros

  4. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, USP. Laboratório de Pediatria, Bloco G. Av. Bandeirantes, 3900. Bairro Monte Alegre, CEP 14048-900, Ribeirão Preto, SãoPaulo, Brazil

    María Sol Brassesco

Authors
  1. María Sol Brassesco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luiz Guilherme Darrigo Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elvis Terci Valera
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ricardo Santos Oliveira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yulie Aparecida Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marcus Vinícius de Castro Barros
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Luiz Gonzaga Tone
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to María Sol Brassesco.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brassesco, M.S., Darrigo, L.G., Valera, E.T. et al. Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection. Childs Nerv Syst 29, 1387–1390 (2013). https://doi.org/10.1007/s00381-013-2154-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-013-2154-0

Keywords

Search

Navigation