Abstract
Introduction
The need for a surgical biopsy for diffuse pontine glioma (DPG) is increasing, and a safer and less invasive procedure is required.
Methods
We describe a transcerebellar stereotactic biopsy procedure that can be safely performed in young children. Four pediatric patients with DPG underwent transcerebellar stereotactic biopsies.
Results
All of the patients were diagnosed with gliomas, and one patient had a transient numbness of the lip margin after the procedure.
Discussion
Transcerebellar stereotactic biopsy is a relatively safe way to obtain a tissue diagnosis for children with DPG.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Khatua S, Moore KR, Vats TS, Kestle JR (2011) Diffuse intrinsic pontine glioma—current status and future strategies. Childs Nerv Syst 27:1391–1397
Donaldson SS, Laningham F, Fisher PG (2006) Advances toward an understanding of brainstem gliomas. J Clin Oncol 24:1266–1272
Albright AL, Packer RJ, Zimmerman R, Rorke LB, Boyett J, Hammond GD (1993) Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children’s Cancer Group. Neurosurgery 33:1026–1029
Stroink AR, Hoffman HJ, Hendrick EB, Humphreys RP (1986) Diagnosis and management of pediatric brain-stem gliomas. J Neurosurg 65:745–750
Nishikawa R (2012) Diffuse intrinsic pontine gliomas: new waves. Neuro Oncol 14:245
Grill J, Puget S, Andreiuolo F, Philippe C, MacConaill L, Kieran MW (2012) Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma. Pediatr Blood Cancer 58:489–491
Puget S, Philippe C, Bax DA, Job B, Varlet P, Junier MP, Andreiuolo F, Carvalho D, Reis R, Guerrini-Rousseau L (2012) Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas. PLoS One 7:e30313
Boviatsis EJ, Voumvourakis K, Goutas N, Kazdaglis K, Kittas C, Kelekis DA (2001) Stereotactic biopsy of brain stem lesions. Minim Invasive Neurosurg 44:226–229
Lobato RD, Rivas JJ (1989) Stereotactic suboccipital transcerebellar biopsy of pontine lesions. J Neurosurg 71:466–467
Mathisen JR, Giunta F, Marini G, Backlund EO (1987) Transcerebellar biopsy in the posterior fossa: 12 years experience. Surg Neurol 28:100–104
Neal JH, Van Norman AS (1993) Transcerebellar biopsy of posterior fossa lesions using the Leksell gamma model stereotactic frame. Neurosurgery 32:473–474
Abernathey CD, Camacho A, Kelly PJ (1989) Stereotaxic suboccipital transcerebellar biopsy of pontine mass lesions. J Neurosurg 70:195–200
Parker P, Levesque MF, Bittoun J, Doyon D, Tadie M (1999) Stereotactic transcerebellar approach to pontine lesions through the middle cerebellar peduncle. Interv Neuroradiol 5:19–25
Sanai N, Wachhorst SP, Gupta NM, McDermott MW (2008) Transcerebellar stereotactic biopsy for lesions of the brainstem and peduncles under local anesthesia. Neurosurgery 63:460–466
Chhang WH, Kak VK, Banerjee AK, Rajwanshi A (1990) Stereotaxic biopsy of brain-stem tumours in children. Childs Nerv Syst 6:409–411
Patel P, Balamurugan M (2009) Transcerebellar stereotactic biopsy for brainstem lesions in children. J Pediatr Neurosci 4:17–19
Roujeau T, Machado G, Garnett MR, Miquel C, Puget S, Geoerger B, Grill J, Boddaert N, Di Rocco F, Zerah M (2007) Stereotactic biopsy of diffuse pontine lesions in children. J Neurosurg 107:1–4
Acknowledgments
This work was supported by the National Research Foundation of Korea grant funded by the Korean government (MEST 2012011770).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Phi, J.H., Chung, HT., Wang, KC. et al. Transcerebellar biopsy of diffuse pontine gliomas in children: a technical note. Childs Nerv Syst 29, 489–493 (2013). https://doi.org/10.1007/s00381-012-1933-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00381-012-1933-3