Skip to main content
SpringerLink
Log in

Atypical teratoid/rhabdoid tumor in an infant conceived by in vitro fertilization

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Background

Atypical teratoid/rhabdoid tumor (ATsRT) is a rare tumor and extremely aggressive embryonal neoplasm of the central nervous system. Brain tumors in infant are suggestive of some oncogenic prenatal factors.

Case presentation

We report on a case of ATRT in a 4-month-old infant conceived by in vitro fertilization (IVF). Some previous reports have raised a question about the possible relation between IVF and childhood cancer, particularly embryonal tumors.

Conclusion

Report of such cases may provide some evidence to identify if there is a real association between congenital tumors and IVF.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Bergh T, Ericson A, Hillensjo T, Nygren KG, Wennerholm UB (1999) Deliveries and children born after in-vitro fertilisation in Sweden 1982–95: a retrospective cohort study. Lancet 354:1578–1585

    Article  Google Scholar 

  2. Brinton LA, Kruger Kjaer S, Thomsen BL, Sharif HF, Graubard BI, Olsen JH, Bock JE (2004) Childhood tumor risk after treatment with ovulationstimulating drugs. Fertil Steril 81:1083–1091

    Article  PubMed  Google Scholar 

  3. Bruinsma F, Venn A, Lancaster P, Speirs A, Healy D (2000) Incidence of cancer in children born after in vitro fertilization. Hum Reprod 15:604–607

    Article  CAS  PubMed  Google Scholar 

  4. Buetow PC, Smirniotopoulos JG, Done S (1990) Congenital brain tumors: a review of 45 cases. AJR Am J Roentgenol 155:587–593

    CAS  PubMed  Google Scholar 

  5. Cohen ZR, Achiron R, Feldman Z (2002) Prenatal sonographic diagnosis of lateral ventricle choroid plexus papilloma in an in vitro fertilization-induced pregnancy. Pediatr Neurosurg 37:267–270

    Article  PubMed  Google Scholar 

  6. Das A, Simmons C, Danielpour M (2005) A congenital brain tumor associated with assisted in vitro fertilization. J Neurosurg 103:451–453

    PubMed  Google Scholar 

  7. Doyle P, Bunch KJ, Beral V, Draper GJ (1998) Cancer incidence in children conceived with assisted reproduction technology. Lancet 352:452–453

    Article  CAS  PubMed  Google Scholar 

  8. Edirisinghe W, Murch A, Junk S, Yovich J (1997) Cytogenetic abnormalities of unfertilized oocytes generated from in-vitro fertilization and intracytoplasmic sperm injection: a double-blind study. Hum Reprod 12:2784–2791

    Article  CAS  PubMed  Google Scholar 

  9. Giuffre R (1989) Biological aspects of brain tumors in infancy and childhood. Childs Nerv Syst 5:55–59

    Article  CAS  PubMed  Google Scholar 

  10. Hansen M, Bower C, Milne E, de Klerk N, Kurinczuk JJ (2005) Assisted reproductive technologies and the risk of birth defects-a systematic review. Hum Reprod 20:328–338

    Article  PubMed  Google Scholar 

  11. Jellinger K, Sunder-Plassmann M (1973) Connatal intracranial tumours. Neuropadiatrie 4:46–63

    Article  CAS  PubMed  Google Scholar 

  12. Kallen B, Finnstrom O, Nygren KG, Olausson PO (2005) In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril 84:605–610

    Article  PubMed  Google Scholar 

  13. Kim YD, Kim KJ, Hy L (2008) Secondary leukemia in a child conceived using in vitro fertilization. Pediatr Int 50:831–832

    Article  CAS  PubMed  Google Scholar 

  14. Klip H, Burger CW, de Kraker J, van Leeuwen FE (2001) Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF. Hum Reprod 16:2451–2458

    CAS  PubMed  Google Scholar 

  15. Kobayashi N, Matsui I, Tanimura M, Nagahara N, Akatsuka J, Hirayama T, Sato K (1991) Childhood neuroectodermal tumours and malignant lymphoma after maternal ovulation induction. Lancet 338:955

    Article  CAS  PubMed  Google Scholar 

  16. Kramer S, Ward E, Meadows AT, Malone KE (1987) Medical and drug risk factors associated with neuroblastoma: a case control study. J Natl Cancer Inst 78:797–804

    CAS  PubMed  Google Scholar 

  17. Lerner-Geva L, Toren A, Chetrit A, Moden B, Mandel M, Rechavi G, Dor J (2000) The risk for cancer among children of women who underwent in vitro fertilization. Cancer 88:2845–2847

    Article  CAS  PubMed  Google Scholar 

  18. Lightfoot T, Bunch K, Ansell P, Murphy M (2005) Ovulation induction, assisted conception and childhood cancer. Eur J Cancer 41:715–724

    Article  PubMed  Google Scholar 

  19. Mandel M, Toren A, Rechavi G, Dor J, Ben-Bassat I, Neumann Y (1994) Hormonal treatment in pregnancy: a possible risk factor for neuroblastoma. Med Pediatr Oncol 23:133–135

    Article  CAS  PubMed  Google Scholar 

  20. Melamed I, Bujanover Y, Hammer J, Spirer Z (1982) Hepatoblastoma in an infant born to a mother after hormonal treatment for sterility. N Engl J Med 307:820

    CAS  PubMed  Google Scholar 

  21. Michalek AM, Buck GM, Nasca PC, Freedman AN, Baptiste MS, Mahoney MC (1996) Gravid health status, medication use, and risk of neuroblastoma. Am J Epidemiol 143:996–1001

    CAS  PubMed  Google Scholar 

  22. Moore SW, Sasco AJ, Dechelotte P, Satgé D (2007) In vitro fertilization and brain tumors. J Neurosurg 106:418

    PubMed  Google Scholar 

  23. Morof DF, Levine D, Stringer KF, Grable I, Folkerth R (2001) Congenital glioblastoma multiforme: prenatal diagnosis on the basis of sonography and magnetic resonance imaging. J Ultrasund Med 20:1375–1396

    Google Scholar 

  24. Plon S, Malkin D (2006) Childhood cancer and heredity. In: Pizzo P, Poplack D (eds) Principles and practice of pediatric oncology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, p 23

    Google Scholar 

  25. Raimondi S, Pedotti P, Taioli E (2005) Meta-analysis of cancer incidance in children born after asisted reproductive tecnologies. Br J Cancer 93:1053–1056

    Article  CAS  PubMed  Google Scholar 

  26. Raisanen J, Hatanpaa KJ, Mickey BE, White CL 3rd (2004) Atypical teratoid/rhabdoid tumor: cytology and differential diagnosis in adults. Diagn Cytopathol 31:60–63

    Article  PubMed  Google Scholar 

  27. Rizk T, Nabbout R, Koussa S, Akatcherian C (2000) Congenital brain tumor in a neonate conceived by in vitro fertilization. Childs Nerv Syst 16:501–502

    Article  CAS  PubMed  Google Scholar 

  28. Rorke LB, Packer RJ, Biegel JA (1996) Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. J Neurosurg 85:56–65

    Article  CAS  PubMed  Google Scholar 

  29. Schieve LA, Rasmussen SA, Buck GM, Schendel DE, Reynolds MA, Wright VC (2004) Are children born after assisted reproductive technology at increased risk for adverse health outcomes? Obstet Gynecol 103:1154–1163

    PubMed  Google Scholar 

  30. Toren A, Sharon N, Mandel M, Neumann Y, Kenet G, Kaplinsky C, Dor J, Rechavi G (1995) Two embryonal cancers after in vitro fertilization. Cancer 76:2372–2374

    Article  CAS  PubMed  Google Scholar 

  31. Voullaire L, Wilton L, McBain J, Callaghan T, Williamson R (2002) Chromosome abnormalities identified by comparative genomic hybridization in embryos from women with repeated implantation failure. Mol Hum Reprod 8:1035–1041

    Article  CAS  PubMed  Google Scholar 

  32. Wakai S, Arai T, Nagai M (1984) Congenital brain tumors. Surg Neurol 21:597–609

    Article  CAS  PubMed  Google Scholar 

  33. White L, Giri N, Vowels MR, Lancaster PA (1990) Neuroectodermal tumours in children born after assisted conception. Lancet 336:1577

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Oncology, Adnan Menderes University School of Medicine, Aydin, 09100, Turkey

    Emre Cecen

  2. Department of Pediatric Oncology, Dokuz Eylul University School of Medicine, Izmir, Turkey

    Dilek Gunes & Kamer Mutafoglu Uysal

  3. Department of Neurosurgery, Dokuz Eylul University School of Medicine, Izmir, Turkey

    Nurullah Yuceer

  4. Department of Pathology, Dokuz Eylul University School of Medicine, Izmir, Turkey

    Erdener Ozer

Authors
  1. Emre Cecen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dilek Gunes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kamer Mutafoglu Uysal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nurullah Yuceer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Erdener Ozer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Emre Cecen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cecen, E., Gunes, D., Uysal, K.M. et al. Atypical teratoid/rhabdoid tumor in an infant conceived by in vitro fertilization. Childs Nerv Syst 26, 263–266 (2010). https://doi.org/10.1007/s00381-009-1005-5

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-009-1005-5

Keywords

Search

Navigation