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Child's Nervous System

, Volume 25, Issue 6, pp 669–675 | Cite as

Unfavorable lipoprotein profile in childhood cancer survivors with suprasellar brain tumors—a high Apo B level and increased small dense LDL-cholesterol

  • Masanori Adachi
  • Koji Muroya
  • Yumi Asakura
Original Paper

Abstract

Objective

The purpose of this study is to evaluate atherosclerotic potency among childhood cancer survivors (CCS) with suprasellar tumors.

Study design

Patients with remitted suprasellar tumors were recruited. A total of 17 subjects with simple obesity of similar ages served as obese controls. Fasting sera were subjected to determination of lipids and apolipoproteins (Apo), including small dense LDL-cholesterol (sdLDL-C).

Results

Twenty-three patients (4–22 years old) were enrolled. Patients, 12/23, had a body mass index (BMI) above the 90th percentile and were designated as ‘obese patients’. Obese patients had lower BMI scores (mean 26.4 kg/m2, p < 0.01) compared to obese controls (mean 31.5 kg/m2). Both groups had identical levels of total cholesterol, triglycerides, LDL-C, and HDL-C. However, obese patients were found to have a higher incidence of Apo B/Apo A1 ratio elevation (6/12) than obese controls (0/17, p < 0.01). In addition, obese patients had higher sdLDL-C level (47.6 ± 14.8 mg/dL) than obese controls (28.3 ± 7.1 mg/dL, p < 0.01). BMI showed strong correlations with both the Apo B/Apo A1 ratio (r = 0.663, p < 0.001) and sdLDL-C (r = 0.606, p < 0.01).

Conclusion

CCS with suprasellar tumors, especially patients with a high BMI, had an unfavorable lipoprotein profile characterized by increased Apo B and sdLDL-C.

Keywords

Apolipoprotein Atherosclerosis Craniopharyngioma Familial combined hyperlipidemia Germinoma Hyperlipidemia Hypothalamic obesity 

Notes

Acknowledgments

This work was made possible by a grant from the Foundation for Growth Science (Tokyo, Japan).

Competing interests

None of the authors has any conflict of interest to declare.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Endocrinology and Metabolism, Clinical Research InstituteKanagawa Children’s Medical CenterYokohamaJapan

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