Unfavorable lipoprotein profile in childhood cancer survivors with suprasellar brain tumors—a high Apo B level and increased small dense LDL-cholesterol
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The purpose of this study is to evaluate atherosclerotic potency among childhood cancer survivors (CCS) with suprasellar tumors.
Patients with remitted suprasellar tumors were recruited. A total of 17 subjects with simple obesity of similar ages served as obese controls. Fasting sera were subjected to determination of lipids and apolipoproteins (Apo), including small dense LDL-cholesterol (sdLDL-C).
Twenty-three patients (4–22 years old) were enrolled. Patients, 12/23, had a body mass index (BMI) above the 90th percentile and were designated as ‘obese patients’. Obese patients had lower BMI scores (mean 26.4 kg/m2, p < 0.01) compared to obese controls (mean 31.5 kg/m2). Both groups had identical levels of total cholesterol, triglycerides, LDL-C, and HDL-C. However, obese patients were found to have a higher incidence of Apo B/Apo A1 ratio elevation (6/12) than obese controls (0/17, p < 0.01). In addition, obese patients had higher sdLDL-C level (47.6 ± 14.8 mg/dL) than obese controls (28.3 ± 7.1 mg/dL, p < 0.01). BMI showed strong correlations with both the Apo B/Apo A1 ratio (r = 0.663, p < 0.001) and sdLDL-C (r = 0.606, p < 0.01).
CCS with suprasellar tumors, especially patients with a high BMI, had an unfavorable lipoprotein profile characterized by increased Apo B and sdLDL-C.
KeywordsApolipoprotein Atherosclerosis Craniopharyngioma Familial combined hyperlipidemia Germinoma Hyperlipidemia Hypothalamic obesity
This work was made possible by a grant from the Foundation for Growth Science (Tokyo, Japan).
None of the authors has any conflict of interest to declare.
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