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A review on the management of epilepsy associated with hypothalamic hamartomas

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Abstract

Introduction

Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay.

Clinical presentation

Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs.

Summary

This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.

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References

  1. Akai T, Okamoto K, Iizuka H, Kakinuma H, Nojima T (2002) Treatments of hamartoma with neuroendoscopic surgery and stereotactic radiosurgery: a case report. Minim Invasive Neurosurg 45:235–239

    Article  CAS  PubMed  Google Scholar 

  2. Arita K, Ikawa F, Kurisu K, Sumida M, Harada K, Uozumi T, Monden S, Yoshida J, Nishi Y (1999) The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg 91:212–220

    Article  CAS  PubMed  Google Scholar 

  3. Arita K, Kurisu K, Iida K, Hanaya R, Akimitsu T, Hibino S, Pant B, Hamasaki M, Shinagawa S (1998) Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report. J Neurosurg 89:645–648

    Article  CAS  PubMed  Google Scholar 

  4. Arzimanoglou AA, Hirsch E, Aicardi J (2003) Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutions. Epileptic Disord 5:187–199

    PubMed  Google Scholar 

  5. Barajas MA, Ramirez-Guzman MG, Rodriguez-Vazquez C, Toledo-Buenrostro V, Cuevas-Solorzano A, Rodriguez-Hernandez G (2005) Gamma knife surgery for hypothalamic hamartomas accompanied by medically intractable epilepsy and precocious puberty: experience in Mexico. J Neurosurg 102(Suppl):53–55

    Article  PubMed  Google Scholar 

  6. Berkovic SF, Andermann F, Melanson D, Ethier RE, Feindel W, Gloor P (1988) Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging. Ann Neurol 23:429–439

    Article  CAS  PubMed  Google Scholar 

  7. Berkovic SF, Arzimanoglou A, Kuzniecky R, Harvey AS, Palmini A, Andermann F (2003) Hypothalamic hamartoma and seizures: a treatable epileptic encephalopathy. Epilepsia 44:969–973

    Article  PubMed  Google Scholar 

  8. Berkovic SF, Kuzniecky RI, Andermann F (1997) Human epileptogenesis and hypothalamic hamartomas: new lessons from an experiment of nature. Epilepsia 38:1–3

    Article  CAS  PubMed  Google Scholar 

  9. Boyko OB, Curnes JT, Oakes WJ, Burger PC (1991) Hamartomas of the tuber cinereum: CT, MR, and pathologic findings. AJNR Am J Neuroradiol 12:309–314

    CAS  PubMed  Google Scholar 

  10. Brandberg G, Raininko R, Eeg-Olofsson O (2004) Hypothalamic hamartoma with gelastic seizures in Swedish children and adolescents. Eur J Paediatr Neurol 8:35–44

    Article  PubMed  Google Scholar 

  11. Breningstall GN (1985) Gelastic seizures, precocious puberty, and hypothalamic hamartoma. Neurology 35:1180–1183

    CAS  PubMed  Google Scholar 

  12. Cascino GD, Andermann F, Berkovic SF, Kuzniecky RI, Sharbrough FW, Keene DL, Bladin PF, Kelly PJ, Olivier A, Feindel W (1993) Gelastic seizures and hypothalamic hamartomas: evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment. Neurology 43:747–750

    CAS  PubMed  Google Scholar 

  13. Choi JU, Yang KH, Kim TG, Chang JH, Chang JW, Lee BI, Kim DS (2004) Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases. J Neurosurg 100:506–511

    PubMed  Google Scholar 

  14. Coulter D (1997) Thalamocortical anatomy and physiology. In: Engel J, Pedley T (eds) Epilepsy: a comprehensive textbook. Lippincott-Raven, Philadelphia, pp 341–351

    Google Scholar 

  15. Daly DD, Mulder DW (1957) Gelastic epilepsy. Neurology 7:189–192

    CAS  PubMed  Google Scholar 

  16. Debeneix C, Bourgeois M, Trivin C, Sainte-Rose C, Brauner R (2001) Hypothalamic hamartoma: comparison of clinical presentation and magnetic resonance images. Horm Res 56:12–18

    Article  CAS  PubMed  Google Scholar 

  17. Delalande O, Fohlen M (2003) Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo) 43:61–68

    Article  Google Scholar 

  18. Deonna T, Ziegler AL (2000) Hypothalamic hamartoma, precocious puberty and gelastic seizures: a special model of “epileptic” developmental disorder. Epileptic Disord 2:33–37

    CAS  PubMed  Google Scholar 

  19. Diebler C, Ponsot G (1983) Hamartomas of the tuber cinereum. Neuroradiology 25:93–101

    Article  CAS  PubMed  Google Scholar 

  20. DiFazio MP, Davis RG (2000) Utility of early single photon emission computed tomography (SPECT) in neonatal gelastic epilepsy associated with hypothalamic hamartoma. J Child Neurol 15:414–417

    Article  CAS  PubMed  Google Scholar 

  21. Dunoyer C, Ragheb J, Resnick T, Alvarez L, Jayakar P, Altman N, Wolf A, Duchowny M (2002) The use of stereotactic radiosurgery to treat intractable childhood partial epilepsy. Epilepsia 43:292–300

    Article  PubMed  Google Scholar 

  22. Feiz-Erfan I, Horn EM, Rekate HL, Spetzler RF, Ng YT, Rosenfeld JV, Kerrigan JF 3rd (2005) Surgical strategies for approaching hypothalamic hamartomas causing gelastic seizures in the pediatric population: transventricular compared with skull base approaches. J Neurosurg 103:325–332

    PubMed  Google Scholar 

  23. Fohlen M, Lellouch A, Delalande O (2003) Hypothalamic hamartoma with refractory epilepsy: surgical procedures and results in 18 patients. Epileptic Disord 5:267–273

    PubMed  Google Scholar 

  24. Frattali CM, Liow K, Craig GH, Korenman LM, Makhlouf F, Sato S, Biesecker LG, Theodore WH (2001) Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma. Neurology 57:43–46

    CAS  PubMed  Google Scholar 

  25. Freeman JL, Coleman LT, Wellard RM, Kean MJ, Rosenfeld JV, Jackson GD, Berkovic SF, Harvey AS (2004) MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol 25:450–462

    PubMed  Google Scholar 

  26. Freeman JL, Harvey AS, Rosenfeld JV, Wrennall JA, Bailey CA, Berkovic SF (2003) Generalized epilepsy in hypothalamic hamartoma: evolution and postoperative resolution. Neurology 60:762–767

    CAS  PubMed  Google Scholar 

  27. Fujimoto Y, Kato A, Saitoh Y, Ninomiya H, Imai K, Sakakibara RI, Maruno M, Kishima H, Yoshimura K, Hasegawa H, Yoshimine T (2003) Stereotactic radiofrequency ablation for sessile hypothalamic hamartoma with an image fusion technique. Acta Neurochir (Wien) 145:697–700, discussion 700-691

    Article  CAS  Google Scholar 

  28. Fukuda M, Kameyama S, Wachi M, Tanaka R (1999) Stereotaxy for hypothalamic hamartoma with intractable gelastic seizures: technical case report. Neurosurgery 44:1347–1350

    Article  PubMed  Google Scholar 

  29. Gore PA, Nakaji P, Deshmukh V, Rekate HL (2006) Synchronous endoscopy and microsurgery: a novel strategy to approach complex ventricular lesions. Report of three cases. J Neurosurg 105:485–489

    Article  PubMed  Google Scholar 

  30. Harvey AS, Freeman JL (2007) Epilepsy in hypothalamic hamartoma: clinical and EEG features. Semin Pediatr Neurol 14:60–64

    Article  PubMed  Google Scholar 

  31. Harvey AS, Freeman JL, Berkovic SF, Rosenfeld JV (2003) Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Epileptic Disord 5:257–265

    PubMed  Google Scholar 

  32. Homma J, Kameyama S, Masuda H, Ueno T, Fujimoto A, Oishi M, Fukuda M (2007) Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures. Epilepsy Res 76:15–21

    Article  PubMed  Google Scholar 

  33. Jung H, Neumaier Probst E, Hauffa BP, Partsch CJ, Dammann O (2003) Association of morphological characteristics with precocious puberty and/or gelastic seizures in hypothalamic hamartoma. J Clin Endocrinol Metab 88:4590–4595

    Article  CAS  PubMed  Google Scholar 

  34. Kahane P, Ryvlin P, Hoffmann D, Minotti L, Benabid AL (2003) From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord 5:205–217

    PubMed  Google Scholar 

  35. Kerrigan JF, Ng YT, Chung S, Rekate HL (2005) The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol 12:119–131

    Article  PubMed  Google Scholar 

  36. Kramer U, Spector S, Nasser W, Siomin V, Fried I, Constantini S (2001) Surgical treatment of hypothalamic hamartoma and refractory seizures: a case report and review of the literature. Pediatr Neurosurg 34:40–42

    Article  CAS  PubMed  Google Scholar 

  37. Kuzniecky R, Guthrie B, Mountz J, Bebin M, Faught E, Gilliam F, Liu HG (1997) Intrinsic epileptogenesis of hypothalamic hamartomas in gelastic epilepsy. Ann Neurol 42:60–67

    Article  CAS  PubMed  Google Scholar 

  38. Kuzniecky RI, Guthrie BL (2003) Stereotactic surgical approach to hypothalamic hamartomas. Epileptic Disord 5:275–280

    PubMed  Google Scholar 

  39. Leal AJ, Moreira A, Robalo C, Ribeiro C (2003) Different electroclinical manifestations of the epilepsy associated with hamartomas connecting to the middle or posterior hypothalamus. Epilepsia 44:1191–1195

    Article  PubMed  Google Scholar 

  40. Likavec AM, Dickerman RD, Heiss JD, Liow K (2000) Retrospective analysis of surgical treatment outcomes for gelastic seizures: a review of the literature. Seizure 9:204–207

    Article  CAS  PubMed  Google Scholar 

  41. Machado HR, Hoffman HJ, Hwang PA (1991) Gelastic seizures treated by resection of a hypothalamic hamartoma. Childs Nerv Syst 7:462–465

    Article  CAS  PubMed  Google Scholar 

  42. Maixner W (2006) Hypothalamic hamartomas—clinical, neuropathological, and surgical aspects. Childs Nerv Syst 22:867–873

    Article  PubMed  Google Scholar 

  43. Mathieu D, Kondziolka D, Niranjan A, Flickinger J, Lunsford LD (2006) Gamma knife radiosurgery for refractory epilepsy caused by hypothalamic hamartomas. Stereotact Funct Neurosurg 84:82–87

    Article  PubMed  Google Scholar 

  44. Morrell F (1985) Secondary epileptogenesis in man. Arch Neurol 42:318–335

    CAS  PubMed  Google Scholar 

  45. Morrell F (1989) Varieties of human secondary epileptogenesis. J Clin Neurophysiol 6:227–275

    Article  CAS  PubMed  Google Scholar 

  46. Mottolese C, Stan H, Bret P, Berlier P, Lapras C (2001) Hypothalamic hamartoma: the role of surgery in a series of eight patients. Childs Nerv Syst 17:229–236, discussion 237-228

    Article  CAS  PubMed  Google Scholar 

  47. Mullatti N (2003) Hypothalamic hamartoma in adults. Epileptic Disord 5:201–204

    PubMed  Google Scholar 

  48. Mullatti N, Selway R, Nashef L, Elwes R, Honavar M, Chandler C, Morris R, Jarosz J, Buchanan C, Polkey C (2003) The clinical spectrum of epilepsy in children and adults with hypothalamic hamartoma. Epilepsia 44:1310–1319

    Article  PubMed  Google Scholar 

  49. Munari C, Kahane P, Francione S, Hoffmann D, Tassi L, Cusmai R, Vigevano F, Pasquier B, Betti OO (1995) Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study). Electroencephalogr Clin Neurophysiol 95:154–160

    Article  CAS  PubMed  Google Scholar 

  50. Murphy JV, Wheless JW, Schmoll CM (2000) Left vagal nerve stimulation in six patients with hypothalamic hamartomas. Pediatr Neurol 23:167–168

    Article  CAS  PubMed  Google Scholar 

  51. Ng YT, Kerrigan JF, Prenger EC, White WL, Rekate HL (2005) Successful resection of a hypothalamic hamartoma and a Rathke cleft cyst. Case report. J Neurosurg 102:78–80

    PubMed  Google Scholar 

  52. Ng YT, Rekate HL (2007) Endoscopic resection of hypothalamic hamartoma for refractory epilepsy: preliminary report. Semin Pediatr Neurol 14:99–105

    Article  PubMed  Google Scholar 

  53. Ng Y, Rekate H, Kerrigan J et al (2004) Transcallosal resection of hypothalamic hamartoma: case report. Barrow Quarterly 20:No 1

  54. Ng YT, Rekate HL, Prenger EC, Chung SS, Feiz-Erfan I, Wang NC, Varland MR, Kerrigan JF (2006) Transcallosal resection of hypothalamic hamartoma for intractable epilepsy. Epilepsia 47:1192–1202

    Article  PubMed  Google Scholar 

  55. Ng YT, Rekate HL, Prenger EC, Wang NC, Chung SS, Feiz-Erfan I, Johnsonbaugh RE, Varland MR, Kerrigan JF (2008) Endoscopic resection of hypothalamic hamartomas for refractory symptomatic epilepsy. Neurology 70:1543–1548

    Article  PubMed  Google Scholar 

  56. Nguyen D, Singh S, Zaatreh M, Novotny E, Levy S, Testa F, Spencer SS (2003) Hypothalamic hamartomas: seven cases and review of the literature. Epilepsy Behav 4:246–258

    Article  PubMed  Google Scholar 

  57. Nishio S, Morioka T, Fukui M, Goto Y (1994) Surgical treatment of intractable seizures due to hypothalamic hamartoma. Epilepsia 35:514–519

    Article  CAS  PubMed  Google Scholar 

  58. Northfield DW, Russell DS (1967) Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumour. J Neurol Neurosurg Psychiatry 30:166–173

    Article  CAS  PubMed  Google Scholar 

  59. Paillas JE, Roger J, Toga M, Soulayrol R, Salamon G, Dravet C, Bureau M (1969) Hamartoma of the hypothalamus. Clinical, radiological and histological study. Results of excision. Rev Neurol (Paris) 120:177–194

    CAS  Google Scholar 

  60. Palmini A, Chandler C, Andermann F, Costa Da Costa J, Paglioli-Neto E, Polkey C, Rosenblatt B, Montes J, Martinez JV, Farmer JP, Sinclair B, Aronyk K, Paglioli E, Coutinho L, Raupp S, Portuguez M (2002) Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy. Neurology 58:1338–1347

    CAS  PubMed  Google Scholar 

  61. Palmini A, Paglioli-Neto E, Montes J, Farmer JP (2003) The treatment of patients with hypothalamic hamartomas, epilepsy and behavioural abnormalities: facts and hypotheses. Epileptic Disord 5:249–255

    PubMed  Google Scholar 

  62. Palmini A, Van Paesschen W, Dupont P, Van Laere K, Van Driel G (2005) Status gelasticus after temporal lobectomy: ictal FDG-PET findings and the question of dual pathology involving hypothalamic hamartomas. Epilepsia 46:1313–1316

    Article  PubMed  Google Scholar 

  63. Papez JW (1995) A proposed mechanism of emotion. 1937. J Neuropsychiatry Clin Neurosci 7:103–112

    CAS  PubMed  Google Scholar 

  64. Parrent AG (1999) Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma. Case report. J Neurosurg 91:881–884

    Article  CAS  PubMed  Google Scholar 

  65. Penfold JL, Manson JI, Caldicott WM (1978) Laughing seizures and precocious puberty (case report and review of the literature). Aust Paediatr J 14:185–190

    CAS  PubMed  Google Scholar 

  66. Prigatano GP (2007) Cognitive and behavioral dysfunction in children with hypothalamic hamartoma and epilepsy. Semin Pediatr Neurol 14:65–72

    Article  PubMed  Google Scholar 

  67. Procaccini E, Dorfmuller G, Fohlen M, Bulteau C, Delalande O (2006) Surgical management of hypothalamic hamartomas with epilepsy: the stereoendoscopic approach. Neurosurgery 59:ONS336–ONS344, discussion ONS344-336

    Article  PubMed  Google Scholar 

  68. Quigg M, Barbaro NM (2008) Stereotactic radiosurgery for treatment of epilepsy. Arch Neurol 65:177–183

    Article  PubMed  Google Scholar 

  69. Regis J, Bartolomei F, de Toffol B, Genton P, Kobayashi T, Mori Y, Takakura K, Hori T, Inoue H, Schrottner O, Pendl G, Wolf A, Arita K, Chauvel P (2000) Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 47:1343–1351, discussion 1351-1342

    Article  CAS  PubMed  Google Scholar 

  70. Regis J, Bartolomei F, Hayashi M, Roberts D, Chauvel P, Peragut JC (2000) The role of gamma knife surgery in the treatment of severe epilepsies. Epileptic Disord 2:113–122

    CAS  PubMed  Google Scholar 

  71. Regis J, Bartolomei F, Rey M, Hayashi M, Porcheron D, Chauvel P, Peragut JC (2002) Gamma knife radiosurgery for the treatment of severe epilepsy. Rev Neurol (Paris) 158:405–411

    CAS  Google Scholar 

  72. Regis J, Hayashi M, Eupierre LP, Villeneuve N, Bartolomei F, Brue T, Chauvel P (2004) Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Acta Neurochir Suppl 91:33–50

    CAS  PubMed  Google Scholar 

  73. Regis J, Scavarda D, Tamura M, Villeneuve N, Bartolomei F, Brue T, Morange I, Dafonseca D, Chauvel P (2007) Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Semin Pediatr Neurol 14:73–79

    Article  PubMed  Google Scholar 

  74. Rekate HL, Feiz-Erfan I, Ng YT, Gonzalez LF, Kerrigan JF (2006) Endoscopic surgery for hypothalamic hamartomas causing medically refractory gelastic epilepsy. Childs Nerv Syst 22:874–880

    Article  PubMed  Google Scholar 

  75. Rosenfeld JV, Harvey AS, Wrennall J, Zacharin M, Berkovic SF (2001) Transcallosal resection of hypothalamic hamartomas, with control of seizures, in children with gelastic epilepsy. Neurosurgery 48:108–118

    Article  CAS  PubMed  Google Scholar 

  76. Ryvlin P, Ravier C, Bouvard S, Mauguire F, Le Bars D, Arzimanoglou A, Petit J, Kahane P (2003) Positron emission tomography in epileptogenic hypothalamic hamartomas. Epileptic Disord 5:219–227

    PubMed  Google Scholar 

  77. Sato M, Ushio Y, Arita N, Mogami H (1985) Hypothalamic hamartoma: report of two cases. Neurosurgery 16:198–206

    Article  CAS  PubMed  Google Scholar 

  78. Savard G, Bhanji NH, Dubeau F, Andermann F, Sadikot A (2003) Psychiatric aspects of patients with hypothalamic hamartoma and epilepsy. Epileptic Disord 5:229–234

    PubMed  Google Scholar 

  79. Schulze-Bonhage A, Homberg V, Trippel M, Keimer R, Elger CE, Warnke PC, Ostertag C (2004) Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas. Neurology 62:644–647

    CAS  PubMed  Google Scholar 

  80. Schulze-Bonhage A, Ostertag C (2007) Treatment options for gelastic epilepsy due to hypothalamic hamartoma: interstitial radiosurgery. Semin Pediatr Neurol 14:80–87

    Article  PubMed  Google Scholar 

  81. Schulze-Bonhage A, Trippel M, Wagner K, Bast T, Deimling FV, Ebner A, Elger C, Mayer T, Keimer R, Steinhoff BJ, Spreer J, Fauser S, Ostertag C (2008) Outcome and predictors of interstitial radiosurgery in the treatment of gelastic epilepsy. Neurology 71:277–282

    Article  CAS  PubMed  Google Scholar 

  82. Selch MT, Gorgulho A, Mattozo C, Solberg TD, Cabatan-Awang C, DeSalles AA (2005) Linear accelerator stereotactic radiosurgery for the treatment of gelastic seizures due to hypothalamic hamartoma. Minim Invasive Neurosurg 48:310–314

    Article  CAS  PubMed  Google Scholar 

  83. Sher PK, Brown SB (1976) Gelastic epilepsy. Onset in neonatal period. Am J Dis Child 130:1126–1131

    CAS  PubMed  Google Scholar 

  84. Shim KW, Chang JH, Park YG, Kim HD, Choi JU, Kim DS (2008) Treatment modality for intractable epilepsy in hypothalamic hamartomatous lesions. Neurosurgery 62:847–856, discussion 856

    Article  PubMed  Google Scholar 

  85. Siomin V, Spektor S, Beni-Adani L, Constantini S (2001) Application of the orbito-cranial approach in pediatric neurosurgery. Childs Nerv Syst 17:612–617

    Article  CAS  PubMed  Google Scholar 

  86. Siwanuwatn R, Deshmukh P, Feiz-Erfan I, Rekate HL, Zabramski JM, Spetzler RF, Rosenfeld JV (2005) Microsurgical anatomy of the transcallosal anterior interforniceal approach to the third ventricle. Neurosurgery 56:390–396, discussion 390–396

    Article  PubMed  Google Scholar 

  87. Striano S, Meo R, Bilo L, Cirillo S, Nocerino C, Ruosi P, Striano P, Estraneo A (1999) Gelastic epilepsy: symptomatic and cryptogenic cases. Epilepsia 40:294–302

    Article  CAS  PubMed  Google Scholar 

  88. Sturm JW, Andermann F, Berkovic SF (2000) “Pressure to laugh”: an unusual epileptic symptom associated with small hypothalamic hamartomas. Neurology 54:971–973

    CAS  PubMed  Google Scholar 

  89. Tassinari CA, Riguzzi P, Rizzi R et al (1997) Gelastic seizures. In: Tuxhorn I, Hothausen H, Boenigk H (eds) Paediatric epilepsy syndromes and their surgical treatment. John Libbey, London, pp 429–446

    Google Scholar 

  90. Unger F, Schrottner O, Feichtinger M, Bone G, Haselsberger K, Sutter B (2002) Stereotactic radiosurgery for hypothalamic hamartomas. Acta Neurochir Suppl 84:57–63

    CAS  PubMed  Google Scholar 

  91. Valdueza JM, Cristante L, Dammann O, Bentele K, Vortmeyer A, Saeger W, Padberg B, Freitag J, Herrmann HD (1994) Hypothalamic hamartomas: with special reference to gelastic epilepsy and surgery. Neurosurgery 34:949–958, discussion 958

    Article  CAS  PubMed  Google Scholar 

  92. Weissenberger AA, Dell ML, Liow K, Theodore W, Frattali CM, Hernandez D, Zametkin AJ (2001) Aggression and psychiatric comorbidity in children with hypothalamic hamartomas and their unaffected siblings. J Am Acad Child Adolesc Psychiatry 40:696–703

    Article  CAS  PubMed  Google Scholar 

  93. Wu J, Xu L, Kim DY, Rho JM, St John PA, Lue LF, Coons S, Ellsworth K, Nowak L, Johnson E, Rekate H, Kerrigan JF (2005) Electrophysiological properties of human hypothalamic hamartomas. Ann Neurol 58:371–382

    Article  PubMed  Google Scholar 

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  1. Department of Neurosurgery, Meyer 8-161, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD, 21287, USA

    James L. Frazier, C. Rory Goodwin, Edward S. Ahn & George I. Jallo

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  1. James L. Frazier
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Frazier, J.L., Goodwin, C.R., Ahn, E.S. et al. A review on the management of epilepsy associated with hypothalamic hamartomas. Childs Nerv Syst 25, 423–432 (2009). https://doi.org/10.1007/s00381-008-0798-y

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