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Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells

Child's Nervous System volume 24, pages 1499–1503 (2008)Cite this article

Abstract

Objects

Congenital Subependymal giant cell astrocytoma (SEGA), diagnosed in fetal and neonatal period, is extremely rare. Previous studies have reported poor surgical outcomes of this small group of patients. We encountered a patient diagnosed as congenital SEGA and report the surgical outcome along with interesting immuno-phenotypes of giant tumor cells.

Case

Ventriculomegaly and a hypoechoic mass near the foramen of Monro were detected in a fetus on prenatal ultrasonography in the 35th week of gestation. Surgery was scheduled 2 months later to reduce the risk of operative complications. At postnatal 2 months, gross total resection of the tumor was achieved without complications. The patient had been followed up for 1 year without tumor recurrence. In double immunofluorescence, the prototype cells of SEGA expressed a variety of neural stem cell (nestin and Sox2) and radial glial cell markers (vimentin and brain lipid-binding protein), in addition to glutamate/aspartate transporter and glial fibrillary acidic protein.

Conclusions

Congenital SEGA can be successfully treated with judicious use of observation period and careful evaluation of general conditions. Pathological findings support the concept that SEGA may originate from aberrant radial glial cells in the developing brain.

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Acknowledgment

This study was supported by a grant (no. 7-2005-1216; to Kim S. K.) from the Korean Ministry of Health and Welfare.

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Affiliations

  1. Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Republic of Korea

    Ji Hoon Phi, Byung-Kyu Cho, Kyu-Chang Wang & Seung-Ki Kim

  2. Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea

    Sung-Hye Park

  3. Department of Pediatrics, Seoul National University Children’s Hospital, Seoul, Republic of Korea

    Jong Hee Chae

  4. Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea

    Ki Ho Hong & Sung Sup Park

  5. Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of Korea

    Ji Hyun Kang & Jong Kwan Jun

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  1. Ji Hoon Phi
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  2. Sung-Hye Park
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  4. Ki Ho Hong
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  5. Sung Sup Park
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  8. Byung-Kyu Cho
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  10. Seung-Ki Kim
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Correspondence to Seung-Ki Kim.

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Phi, J.H., Park, SH., Chae, J.H. et al. Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells. Childs Nerv Syst 24, 1499–1503 (2008). https://doi.org/10.1007/s00381-008-0681-x

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  • DOI: https://doi.org/10.1007/s00381-008-0681-x

Keywords

  • Subependymal giant cell astrocytoma
  • Congenital
  • Tuberous sclerosis complex
  • Radial glial cell