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Prognosis of cerebellar astrocytomas in children

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Abstract

Objective

Our main objective is to review a large series of cerebellar astrocytomas in children and evaluate the outcome of the patients depending on astrocytoma class. The effect of astrocytoma characteristics on the children’s prognosis was determined by grouping a series of cerebellar astrocytomas by their location, radiological aspect, size, and histology and determining whether this was related with outcome.

Materials and methods

Two hundred and three children with cerebellar astrocytomas were retrospectively reviewed, and their tumors were classified by location, macroscopic radiological appearance, size, and histology. We have distinguished between patients operated before and after 1974 because of the introduction of new diagnostic (computed tomography, magnetic resonance) and more sophisticated treatment techniques after this year (microsurgery, laser, cavitron, etc).

Results

Our patients’ results were classified according to the Lapras scale/classification as normal, with some neurological deficit but able to lead a normal life, and those with severe post surgical deficits. Recurrences and mortality were also noted. Normal or good results were obtained in 111 patients, some neurological deficit in 55, and severe deficits in nine. There were six recurrences and 22 deaths because of the disease.

Conclusions

Two main factors affected prognosis. One was whether the tumor was completely resected or not; this was the treatment in most cases in this series. The second factor was the location, size, and macroscopic appearance of the tumor. The best prognosis was associated with being located in one hemisphere, being cystic, being cystic with a posterior nodule, and/or being small.

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References

  1. Alpers CE, Davis RL, Wilson CB (1982) Persistence and late malignant transformation of childhood cerebellar astrocytoma. J Neurosurg 57:648–655

    Google Scholar 

  2. Austin EJ, Alvord EC (1988) Recurrences of cerebellar astrocytomas. A violation of Collin’s law. J Neurosurg 68:41–41

    PubMed  CAS  Google Scholar 

  3. Bernell WR, Kepes JJ, Seitz EP (1973) Late malignant recurrence of childhood cerebellar astrocytoma. Report of two cases. J Neurosurg 37:470–474

    Google Scholar 

  4. Bucy PC, Thieman PW (1984) Astrocytomas of the cerebellum: a study of a series of patients operated upon over 28 years old. Arch Neurol 18:14–19

    Google Scholar 

  5. Budka H (1975) Partially resected and irradiated cerebellar astrocytoma of childhood malignant evolution after 28 years. Acta Neurochir 32:139–146

    Article  CAS  Google Scholar 

  6. Crawford JV, Rubinstein LW, Rusell DS (1958) Follow up of cerebellar astrocytoma in relation to their pathology. J Neurol Neurosurg Psychiatry 21:64

    Google Scholar 

  7. Cushing H (1931) Experiences with the cerebellar astrocytomas, a critical review of seventy-six cases. Surg Gynecol Obstet 52:129–204

    Google Scholar 

  8. Davis CH, Joglekar VM (1981) Cerebellar astrocytomas in children and young adults. J Neurol Neurosurg Psychiatry 44:820–828

    PubMed  CAS  Google Scholar 

  9. Dirven CMF, Mooij JJA, Molenaan WM (1997) Cerebellar pilocytic astrocytoma a treatment protocol based upon analysis of 73 cases and review of the literature. Child’s Ner Syst 13:17–23

    Article  CAS  Google Scholar 

  10. Elridge AR (1968) Long term survival in the astrocytomas series. J Neurosurg 28:399–404

    Google Scholar 

  11. Ferbert A, Gullotta F (1985) Remarks on the follow-up of cerebellar astrocytomas. J Neurol 232:134–136

    Article  PubMed  CAS  Google Scholar 

  12. Garcia DM, Latifi HR, Simpson JR, Picker S (1989) Astrocytomas of the cerebellum in children. J Neurosurg 71:661–664

    PubMed  CAS  Google Scholar 

  13. Geissinger JD, Bucy PC (1971) Astrocytomas of the cerebellum in children long term study. Arch Neurol 24:125–135

    PubMed  CAS  Google Scholar 

  14. Gjerris F, Klinken L (1978) Clinical aspects and long term prognosis in children with benign cerebellar astrocytomas. J Neurosurg 49:179–184

    PubMed  CAS  Google Scholar 

  15. Griffin TW, Beaufait D, Blasko JC (1979) Cystic cerebellar astrocytomas to childhood. Cancer 44:276–280

    Article  PubMed  CAS  Google Scholar 

  16. Ilgren EB, Stiller CA (1986) Cerebellar astrocytomas: therapeutic management. Acta Neurochir 81:11–26

    Article  CAS  Google Scholar 

  17. Kehler U, Arnold H, Muller H (1990) Long-term follow-up of infratentorial pilocytic astrocytomas. Neurosurg Rev 13:315–320

    Article  PubMed  CAS  Google Scholar 

  18. Lapras C, Patet JD, Lapras C Jr, Mottolese C (1986) Cerebellar astrocytomas in childhood. Child’s Nerv Syst 2:55–59

    Article  CAS  Google Scholar 

  19. Leviton A, Fulchiero A, Gilles FH, Winston K (1978) Survival status of children with cerebellar gliomas. J Neurosurg 48:29–33

    PubMed  CAS  Google Scholar 

  20. Mabon RF, Swien HJ, Adson AW, Kernohan JW (1950) Astrocytomas of the cerebellum. Arch Neurol Psychiatry 64:74–88

    PubMed  CAS  Google Scholar 

  21. Matson DD (1968) Surgery of the posterior fossa tumors in childhood. Clin Neurosurg 15:247–270

    PubMed  CAS  Google Scholar 

  22. Obrador S, Blazquez MG (1975) Benign cystic tumors of the cerebellum. Acta Neurochir 32:55–68

    Article  CAS  Google Scholar 

  23. Palma L, Russo A, Celli P (1984) Prognosis of the so called “diffuse” cerebellar astrocytoma. Neurosurgery 15:315–317

    Article  PubMed  CAS  Google Scholar 

  24. Pencalet P, Maixner W, Sainte-Rose C, Lellouch-Tubiana A, Cinalli G, Zerah M, Pierre-Kahn A, Hoppe-Hirsh E, Bourgeois M, Renier D (1999) Benign cerebellar astrocytomas in children. J Neurosurg 90:265–273

    Article  PubMed  CAS  Google Scholar 

  25. Rallel C, Edwards MSB, Davis RL et al (1985) Post-irradiation cerebellar glioma. J Neurosurg 62:300–302

    Google Scholar 

  26. Salazar OM (1981) Primary malignant cerebellar astrocytomas in children: a signal for postoperative craniospinal irradiation. Int J Radiat Oncol Biol Phys 7:1661–1665

    PubMed  CAS  Google Scholar 

  27. Schneider JH Jr, Rallel C, McComb JG (1992) Benign cerebellar astrocytomas of childhood. Neurosurgery 30:58–63

    Article  PubMed  Google Scholar 

  28. Scott RM, Ballantine HT (1972) Malignant recurrence after prolonged postoperative survival. J Neurosurg 39:777–779

    Google Scholar 

  29. Steinberg GK, Shuar LM, Conley FK et al (1985) Evolution and outcome in malignant astroglial neoplasms of the cerebellum. J Neurosurg 62:9–10

    PubMed  CAS  Google Scholar 

  30. Sznesy J, Slavik F (1983) Prognosis of benign cerebellar astrocytoma in children. Child Brain 10:39–47

    Article  Google Scholar 

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Correspondence to Francisco Villarejo.

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Villarejo, F., Belinchón de Diego, J.M. & Gómez de la Riva, Á. Prognosis of cerebellar astrocytomas in children. Childs Nerv Syst 24, 203–210 (2008). https://doi.org/10.1007/s00381-007-0449-8

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  • DOI: https://doi.org/10.1007/s00381-007-0449-8

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