Abstract
Introduction
Cadherins are Ca2+-dependent cell-to-cell adhesion molecules that play an important role in tissue construction and morphogenesis in multicellular organisms. Cadherin involvement in tumor metastasis has recently been reported.
Case report
We investigated the expression of E-cadherin and N-cadherin in paraffin-embedded sequential surgical specimens and autopsy specimens from a 4-year-old girl with recurrent ependymoma, subsequent to cerebrospinal fluid (CSF) dissemination. We observed low expression of E-cadherin in all surgical specimens and autopsy specimens. In contrast, expression of N-cadherin was high in all surgical specimens, but was decreased in autopsy specimens.
Conclusion
Decreased expression of N-cadherin may be associated with CSF dissemination and may serve as a useful marker for CSF dissemination in patients with intracranial ependymoma.
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References
Teo C, Nakaji P, Symons P, Tobias V, Cohn R, Smee R (2003) Ependymoma. Childs Nerv Syst 19:270–285
Humpl T, Neuser H, Bruhl K, Bartels U, Schwarz M, Gutjahr P (2001) Clinical aspects and prognosis of ependymoma in infants and children. Childs Nerv Syst 17:246–251
Korshunov A, Golanov A, Timirgaz V (2002) Immunohistochemical markers for prognosis of ependymoma neoplasms. J Neurooncol 58:255–2703
Smyth MD, Horn BN, Russo C, Berger MS (2000) Intracranial ependymomas of childhood: current management strategies. Pediatr Neurosurg 33:138–150
Hazan RB, Qiao R, Keren R, Badano I, Suyama K (2004) Cadherin switch in tumor progression. Ann N Y Acad Sci 1014:155–163
Asano K, Kubo O, Tajika Y, Takakura K, Suzuki S (2000) Expression of cadherin and CSF dissemination in malignant astrocytic tumors. Neurosurg Rev 23:39–44
Asano K, Duntsch CD, Zhou Q, Weimar JD, Bordelon D, Robertson JH, Pourmotabbed T (2004) Correlation of N-cadherin expression in high grade glioma with tissue invasion. J Neurooncol 70:3–15
Fouladi M, Baruchel S, Chan H, Grant R, Malkin D, Weitzman S, Greenberg ML (1998) Use of adjuvant ICE chemotherapy in the treatment of anaplastic ependymoma. Childs Nerv Syst 14:590–595
Packer RJ, Sutton LN, Elterman R, Lange B, Goldwein J, Nicholson HS, Mulne L, Boyett J, D’Angio G, Wechsler-Jentzsch K, Reaman G, Cohen BH, Bruce DA, Rorke LB, Molloy P, Ryan J, Lafond D, Evans AE, Schut L (1994) Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy. J Neurosurg 81:690–698
Kleihues P, Cavanee W (2000) World Health Organization classification of tumours, pathology and genetics, tumours of nervous system. Chapter 3: ependymal tumours. IARC, Lyon
Schwechheimer K, Zhou L, Birchmeier W (1998) E-cadherin in human brain tumours: loss of immunoreactivity in malignant meningiomas. Virchows Arch 432:163–167
Utsuki S, Oka H, Sato Y, Tsutiya B, Kondo K, Tanizaki Y, Tanaka S, Fujii K (2004) E, N-cadherins and beta-catenin expression in medulloblastoma and atypical teratoid/rhabdoid tumor. Neurol Med Chir (Tokyo) 44:402–407
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Yokoi, K., Akiyama, M., Yanagisawa, T. et al. Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma. Childs Nerv Syst 23, 237–242 (2007). https://doi.org/10.1007/s00381-006-0197-1
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DOI: https://doi.org/10.1007/s00381-006-0197-1