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Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumor

Child's Nervous System volume 22, pages 1611–1618 (2006)Cite this article

Abstract

Introduction

Dysembryoplastic neuroepithelial tumor (DNT) frequently causes medically intractable epilepsy.

Objective

The aim of this study was to investigate the basic mechanism of epileptogenecity of the tumor.

Materials and methods

Clinicopathological data in 13 cases of DNT and immunohistochemical changes of ionotropic glutamate receptor subunits in the tumor and peritumoral epileptogenic cortex were studied.

Conclusions

Magnetic resonance imaging combined with electroencephalography (EEG), electrocorticography, and depth-electrode EEG was valuable to localize complicated epileptogenic zones of the patients with DNT. Neuropathological examinations of the peritumoral cerebral cortex presenting abnormal spikes showed different histopathological grades of neuronal migration disorder (NMD). The tumor cells in DNT disclosed increased immunopositivities of N-methyl-d-aspartate receptor 1 (NR1) and NR2A/B, and peritumoral epileptogenic NMD revealed increased immunopositivities of GluR2 and GluR3. The amplification of ionotropic glutamate receptor subunits in the tumor and peritumoral NMD may be the underlying cause of epileptic seizures in DNT patients.

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Acknowledgment

This work was supported by the Korea Science and Engineering Foundation through the Medical Research Center for Gene Regulation (R13-2002-013-01000-0) at Chonnam National University.

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Affiliations

  1. Department of Pathology, Chonnam National University Medical School and Hospital, 5 Hakdong, Dongku, Gwangju, 501-746, South Korea

    Min-Cheol Lee, Jang-Young Kang, Myung-Bok Seol, Hyung-Seok Kim, Jae-Yeon Woo & Ji-Shin Lee

  2. Department of Neurosurgery, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, South Korea

    Shin Jung & Jae-Hyoo Kim

  3. Department of Pediatrics, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, South Korea

    Young-Jong Woo

  4. Department of Neurology, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, South Korea

    Myung-Kyu Kim

  5. Department of Neurosurgery, Jesus Hospital, Chonju, South Korea

    Hyung-Ihl Kim

  6. Department of Brain Disease Research Center, Ajou University, Suwon, South Korea

    Seung-Up Kim

  7. Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    Seung-Up Kim

Authors
  1. Min-Cheol Lee
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  2. Jang-Young Kang
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  3. Myung-Bok Seol
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  4. Hyung-Seok Kim
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  5. Jae-Yeon Woo
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  6. Ji-Shin Lee
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  7. Shin Jung
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  8. Jae-Hyoo Kim
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  9. Young-Jong Woo
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  10. Myung-Kyu Kim
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  11. Hyung-Ihl Kim
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  12. Seung-Up Kim
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Corresponding author

Correspondence to Min-Cheol Lee.

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Lee, MC., Kang, JY., Seol, MB. et al. Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumor. Childs Nerv Syst 22, 1611–1618 (2006). https://doi.org/10.1007/s00381-006-0162-z

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Keywords

  • Dysembryoplastic neuroepithelial tumor
  • Epilepsy
  • Glutamate receptor
  • Immunohistochemistry
  • Neuronal migration disorder