Child's Nervous System

, Volume 22, Issue 12, pp 1631–1633 | Cite as

Spontaneous isolated non-haemorrhagic thrombosis in a child with development venous anomaly: case report and review of the literature

  • A. Vieira SantosEmail author
  • P. Saraiva
Case Report



The natural history of developmental venous anomalies (DVAs) is said to be relatively benign.

Case report

We herein report the clinical case of a 9-year-old female child with sudden right hemiparesis. An ischaemic infarct secondary to an isolated spontaneous thrombosis of a DVA was diagnosed by brain magnetic resonance imaging, further confirmed by digital subtraction angiography.


Considering the therapeutic options, early diagnosis is mandatory.


DVAs Ischemic venous infarct Rare MRI Cerebral angiography Plasminogen activator inhibitor-1 


  1. 1.
    Lasjaunias P, Burrows P, Planet C (1986) Developmental venous anomalies (DVA): the so-called venous angioma. Neurosurg Rev 9(3):233–242PubMedCrossRefGoogle Scholar
  2. 2.
    Sarwar M, McCormick WF (1978) Intracerebral venous angioma. Case report and review. Arch Neurol 35(5):323–325PubMedGoogle Scholar
  3. 3.
    Topper R, Jurgens E, Reul J, Thron A (1999) Clinical significance of intracranial developmental venous anomalies. J Neurol Neurosurg Psychiatry 67(2):234–238PubMedCrossRefGoogle Scholar
  4. 4.
    Timothy B, Garner MD, O Del Curling MD Jr, David L Kelly MD Jr, Wayne Laster MD (1991) The natural history of intracranial venous angiomas. J Neurosurg 75:715–722Google Scholar
  5. 5.
    Wilms G, Bleus E, Demaerel P, Marchal G, Plets C, Goffin J, Baert AL (1994) Simultaneous occurrence of developmental venous anomalies and cavernous angiomas. Am J Neuroradiol 15(7):1247–1254PubMedGoogle Scholar
  6. 6.
    Peltier J, Toussaint P, Desenclos C, Le Gars D, Deramond H (2004) Cerebral venous angioma of the pons complicated by nonhemorrhagic infarction. Case report. J Neurosurg 101(4):690–693PubMedCrossRefGoogle Scholar
  7. 7.
    Valavanis A, Wellauer J, Yasargil MG (1983) The radiological diagnosis of cerebral venous angioma: cerebral angiography and computed tomography. Neuroradiology 24:193–199PubMedCrossRefGoogle Scholar
  8. 8.
    Truwit CL (1992) Venous angioma of the brain: history, significance and imaging findings. AM J Roentgenol 159:1299–1307Google Scholar
  9. 9.
    Lee C, Pennington MA, Kenney CM III (1996) MR evaluation of developmental venous anomalies: medullary venous anatomy of venous angiomas. Am J Neuroradiol 17(1):61–70PubMedGoogle Scholar
  10. 10.
    Lasjaunias P, Terbrugge K, Rodesch G, Willinsky R, Burrows P, Pruvost Ph, Piske R (1989) Vraies et fausses lesions veineuses cérébrales: pseudo-angiomes veineux et hémangiomes caverneux. Neurochirurgie 35:132–139PubMedGoogle Scholar
  11. 11.
    Dillon et al (1991) ASNR meeting highlights, paper 208. Am J Neuroradiol 12:1245–1246Google Scholar
  12. 12.
    Maeder P, Gudinchet F, Meuli R, de Tribolet N (1998) Development of a cavernous malformation of the brain. Am J Neuroradiol 19(6):1141–1143PubMedGoogle Scholar
  13. 13.
    Baumeister FA, Auberger K, Schneider K (2000) Thrombosis of the deep cerebral veins with excessive bilateral infarction in a premature infant with the thrombogenic 4G/4G genotype of the plasminogen activator inhibitor-1. Eur J Pediatr 159(4):239–242PubMedCrossRefGoogle Scholar
  14. 14.
    Heineking B, Riebel T, Scheer I, Kulozik A, Hoehn T, Buhrer C (2003) Intraventricular hemorrhage in a full-term neonate associated with sinus venous thrombosis and homozygosity for the plasminogen activator inhibitor-1 4G/4G polymorphism. Pediatr Int 45(1):93–96PubMedCrossRefGoogle Scholar
  15. 15.
    Konan AV, Raymond J, Bourgouin P, Lesage J, Milot G, Roy D (1999) Cerebellar infarct caused by spontaneous thrombosis of a developmental venous anomaly of the posterior fossa. Am J Neuroradiol 20(2):256–258PubMedGoogle Scholar
  16. 16.
    Lovblad KO, Bassetti C, Schneider J, Guzman R, El-Koussy M, Remonda L, Schroth G (2001) Diffusion-weighted MR in cerebral venous thrombosis. Cerebrovasc Dis 11(3):169–176PubMedCrossRefGoogle Scholar
  17. 17.
    Forbes KP, Pipe JG, Heiserman JE (2001) Evidence for cytotoxic edema in the pathogenesis of cerebral venous infarction. Am J Neuroradiol 22(3):450–455PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Neuroradiology DepartmentGarcia de Orta HospitalAlmadaPortugal

Personalised recommendations