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Primary central nervous system non-Hodgkin lymphoma in childhood presenting as bilateral optic neuritis

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Abstract

Inroduction

Primary central nervous system lymphoma is a very rare condition in pediatric patients.

Case report

We describe the case of a 10-year old girl who presented with acute bilateral vision impairment. At the time of presentation, the only positive finding was optic disk swelling, and the brain MRI scan was normal. Seventeen months later, she developed a large-cell non-Hodgkin lymphoma in the brain, with no evidence of neoplasia elsewhere. Immunodeficiencies and Epstein–Barr virus infection could not be demonstrated. The patient was successfully treated with a combination of cyclophosphamide, etoposide, vincristine, methotrexate, and cytarabine, plus intrathecal chemotherapy. Craneospinal irradiation was not used.

Outcome

The patient’s condition is still in remission 68 months after completing the treatment.

Conclusion

This case is the only non-Hodgkin lymphoma with primary central nervous system location treated in our institution in the last 10 years and represents less than 0.5% of our non-Hodgkin lymphoma series. Due to its rare occurrence, not much is known about the clinical features and treatment outcome of primary central nervous system lymphoma in pediatric patients.

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Authors and Affiliations

  1. Department of Oncology, Hospital Infantil de México Federico Gomez, Dr. Marquez Num 162, Colonia Doctores, C.P. 06720, Distrito Federal, México

    Aurora Medina-Sanson & Sergio Gallegos-Castorena

  2. Department of Neurosurgery, Hospital Infantil de México Federico Gomez, Dr. Marquez Num 162, Colonia Doctores, C.P. 06720, Distrito Federal, México

    Fernado Chico-Ponce de León

  3. Department of Pathology, Hospital Infantil de México Federico Gomez, Dr. Marquez Num 162, Colonia Doctores, C.P. 06720, Distrito Federal, México

    María de Lourdes Cabrera-Muñoz

  4. Department of Infectology, Hospital Infantil de México Federico Gomez, Dr. Marquez Num 162, Colonia Doctores, C.P. 06720, Distrito Federal, México

    Raul Caltenco-Serrano

  5. Department of Neurology, Hospital Infantil de México Federico Gomez, Dr. Marquez Num 162, Colonia Doctores, C.P. 06720, Distrito Federal, México

    Eduardo Barragán-Pérez

Authors
  1. Aurora Medina-Sanson
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  2. Fernado Chico-Ponce de León
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  3. María de Lourdes Cabrera-Muñoz
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  4. Sergio Gallegos-Castorena
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  5. Raul Caltenco-Serrano
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  6. Eduardo Barragán-Pérez
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Corresponding author

Correspondence to Aurora Medina-Sanson.

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Medina-Sanson, A., Chico-Ponce de León, F., Cabrera-Muñoz, M. et al. Primary central nervous system non-Hodgkin lymphoma in childhood presenting as bilateral optic neuritis. Childs Nerv Syst 22, 1364–1368 (2006). https://doi.org/10.1007/s00381-006-0093-8

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  • DOI: https://doi.org/10.1007/s00381-006-0093-8

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