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Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature

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Abstract

Case reports

The authors report their experience about three children (two girls, one boy; average age 1.6 years) with a spontaneous regression of optic gliomas. All of them had a previous diagnosis of neurofibromatosis type 1 (NF 1). None of them underwent surgery or biopsy nor received chemotherapy or radiotherapy. The complete regression was documented by MRI scans performed during a mean follow-up of 6.3 years.

Literature review

Moreover, the authors analyze the features of the 16 cases previously reported in English literature of spontaneously regressed optic gliomas with an overview of the different therapeutic strategies. The knowledge that this kind of tumor, particularly in young patients, may regress is important in the decision of the best therapeutic approach.

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Authors and Affiliations

  1. Department of Neurosurgical Sciences, Neurosurgery, University of Rome, La Sapienza, Rome, Italy

    Manolo Piccirilli, Jacopo Lenzi, Catia Delfinis, Guido Trasimeni, Maurizio Salvati & Antonino Raco

  2. Department of Neuroradiology, Sant’Andrea Hospital, Rome, Italy

    Guido Trasimeni

  3. Neurosurgery, INM Neuromed, Pozzilli (IS), Italy

    Maurizio Salvati & Antonino Raco

Authors
  1. Manolo Piccirilli
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  2. Jacopo Lenzi
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  3. Catia Delfinis
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  4. Guido Trasimeni
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  5. Maurizio Salvati
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  6. Antonino Raco
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Correspondence to Antonino Raco.

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Piccirilli, M., Lenzi, J., Delfinis, C. et al. Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature. Childs Nerv Syst 22, 1332–1337 (2006). https://doi.org/10.1007/s00381-006-0061-3

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  • DOI: https://doi.org/10.1007/s00381-006-0061-3

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