Abstract
Rationale
Meningiomas in the pediatric age group are very rare tumors, comprising about 1–4.2% of all primary pediatric intracranial tumors.
Case report
We present a 17-year-old patient who suffered from an intraventricular malignant meningioma. At the age of 2 years, acute lymphatic leukemia (common ALL [cALL]) was diagnosed and successfully treated with chemotherapy. There was no cranial radiation therapy.
In December 2001, 13 years after diagnosis of cALL, he complained of headache, vomiting, and walking difficulties. Magnetic resonance imaging showed an enhancing mass with cystic components in the trigone of the right lateral ventricle. The tumor was removed completely. Histological diagnosis revealed a malignant papillary meningioma. After removal of a recurrent meningioma 16 months later, he received local radiotherapy.
Conclusion
Pathogenetic mechanisms, treatment options, and prognosis of meningiomas and secondary malignancies of this age group are discussed.
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References
Amirjamshidi A, Mehrazin M, Abbassioun K (2000) Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature. Childs Nerv Syst 16:406–416
Bhatia S, Sather HN, Pabustan OB et al (2002) Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983. Blood 99:4257–4264
Blay JY, Conroy T, Chevreau C et al (1998) High-dose methotrexate for the treatment of primary cerebral lymphomas: analysis of survival and late neurologic toxicity in a retrospective series. J Clin Oncol 16:864–871
Brenner DJ, Elliston CD, Hall EJ, Berdon WE (2001) Estimates of the cancer risks from pediatric CT radiation are not merely theoretical: comment on point/counterpoint: in x-ray computed tomography, technique factors should be selected appropriate to patient size. against the proposition. Med Phys 28:2387–2388
Carra S, Drigo P, Gardiman M et al (2001) Clear-cell meningioma in a 22-month-old male: a case report and literature review. Pediatr Neurosurg 34:264–267
Doty JR, Schut L, Bruce DA, Sutton LN (1987) Intracranial meningiomas of childhood and adolescence. Prog Exp Tumor Res 30:247–254
Hojo H, Abe M (2001) Rhabdoid papillary meningioma. Am J Surg Pathol 25:964–969
Im SH, Wang KC, Kim SK et al (2001) Childhood meningioma: unusual location, atypical radiological findings, and favorable treatment outcome. Childs Nerv Syst 17:656–662
Iuvone L, Mariotti P, Colosimo C et al (2002) Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia. Cancer 95:2562–2570
Kohama I, Sohma T, Nunomura K et al (1996) Intraparenchymal meningioma in an infant-case report. Neurol Med Chir (Tokyo) 36:598–601
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Regel, J.P., Schoch, B., Sandalcioglu, I.E. et al. Malignant meningioma as a second malignancy after therapy for acute lymphatic leukemia without cranial radiation. Childs Nerv Syst 22, 172–175 (2006). https://doi.org/10.1007/s00381-005-1143-3
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DOI: https://doi.org/10.1007/s00381-005-1143-3