Skip to main content

Advertisement

SpringerLink
Log in

Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Background

Pineoblastomas are very rare brain tumors in fetus and neonates, comprising only 0.9% of congenital brain tumors. The occurrence of multiple tumors of different histopathologic types in the same individual is a rare event, most often encountered in hereditary cancer syndromes.

Case report

We report a female fetus presented with a congenital pineoblastoma at the 32nd week of gestation, with hydrocephalus and concurrent parameningeal embryonal rhabdomyosarcoma in early infancy.

Results

Cytogenetic analysis showed normal karyotype in the peripheral blood of the patient, and p53 mutational analysis revealed no germ line mutations.

Discussion

This is the first case with concurrent congenital pineoblastoma and parameningeal embryonal rhabdomyosarcoma in early infancy. We suggest that concurrence of these tumors could be due to mutations in other tumor suppressor genes or secondary to exposure to unknown in utero factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Balestrini MR, Micheli R, Giordano L, Lasio G, Giombini S (1994) Brain tumors with symptomatic onset in the first two years of life. Childs Nerv Syst 10:104–110

    Article  PubMed  CAS  Google Scholar 

  2. Isaacs HJR (2002) I. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol 27:249–261

    Article  PubMed  Google Scholar 

  3. Rickert CH, Porobst-Cousin S, Louwen F, Feldt B, Gullotta F (1997) Congenital immature teratoma of the fetal brain. Childs Nerv Syst 13:556–559

    Article  PubMed  CAS  Google Scholar 

  4. Isaacs HJR (2002) II. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol 27:333–342

    Article  PubMed  Google Scholar 

  5. Jakacki RI (1999) Pineal and nonpineal supratentorial primitive neuroectodermal tumors. Childs Nerv Syst 15:586–591

    Article  PubMed  CAS  Google Scholar 

  6. Brockmeyer DL, Walker ML, Thompson G, Fults DW (1997) Astrocytoma and pineoblastoma arising sequentially in the fourth ventricle of the same patient. Case report and molecular analysis. Pediatr Neurosurg 26:36–40

    Article  PubMed  CAS  Google Scholar 

  7. Marec-Berard P, Jouvet A, Thiesse P, Kalifa C, Doz F, Frappaz D (2002) Supratentorial embryonal tumors in children under 5 years of age: an SFOP study of treatment with postoperative chemotherapy alone. Med Pediatr Oncol 38:83–90

    Article  PubMed  CAS  Google Scholar 

  8. Im SH, Wang KC, Kim SK, Lee YH, Chi JG, Cho BK (2003) Congenital intracranial teratoma. Prenatal diagnosis and postnatal successful resection. Med Pediatr Oncol 40:57–61

    Article  PubMed  Google Scholar 

  9. Mazouni C, Porcu-Buisson G, Girard N, Sakr R, Figarella-Ballanger D, Guidicelli B, Bonnier P, Gamerre M (2003) Intrauterine brain teratoma: a case report of imaging (US, MRI) with neuropathologic correlations. Prenat Diagn 23:104–107

    Article  PubMed  Google Scholar 

  10. Girard N, Raybaud C, Gambarelli D, Figarella-Ballanger D (2001) Pediatric MR neuroimaging. Fetal brain MR imaging. Magn Reson Imaging Clin North Am 9:19–56

    CAS  Google Scholar 

  11. Cho BK, Wang KC, Man DH, Jung HW, Kim HJ, Han DH, Choi KS (1998) Pineal tumors: experience with 48 cases over 10 years. Childs Nerv Syst 14:53–58

    Article  PubMed  CAS  Google Scholar 

  12. Oi S, Matsuzawa K, Choi JU, Kim DS, Kang JK, Cho BK (1998) Identical characteristics of the patient populations with pineal region tumors in Japan and in Korea and therapeutic modalities. Childs Nerv Syst 14:36–40

    Article  PubMed  CAS  Google Scholar 

  13. Diller L, Sexsmith E, Gottlieb A, Li FP, Malkin D (1995) Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest 95:1606–1611

    Article  PubMed  CAS  Google Scholar 

  14. Merimsky O, Kollender Y, Issakov J, Bickels J, Flusser G, Gutman M, Lev-Chelouche D, Inbar M, Meller I (2001) Multiple primary malignancies in association with soft tissue sarcomas. Cancer 91:1361–1371

    Article  Google Scholar 

  15. Khayat CM, Johnston DL (2004) Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with germline p53 mutation. Pediatr Blood Cancer 43:683–686

    Article  PubMed  Google Scholar 

  16. Stander M, Peraud A, Leroch B, Kreth FW (2004) Prognostic impact of TP53 mutation status for adult patients with supratentorial World Health Organization grade II astrocytoma or oligoastrocytoma. A long-term analysis. Cancer 101:1028–1035

    Article  PubMed  Google Scholar 

  17. Tsumanuma I, Sato M, Okazaki H, Tanaka R, Washiyama K, Kawasaki T, Kumanishi T (1995) The analysis of p53 tumor suppressor gene in pineal parenchymal tumors. Noshuyo Byori 12:39–43

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Oncology, Kocaeli University, Kocaeli, Turkey

    Funda Çorapçíoğlu

  2. Division of Pediatric Neurosurgery, Marmara University Medical Center, Istanbul, Turkey

    M. Memet Özek

  3. Department of Pathology, Marmara University Medical Center, Istanbul, Turkey

    Aydın Sav

  4. BilGen Genetic Diagnosis Center, Bilkent University, Ankara, Turkey

    Deniz Üren

  5. Acıbadem, P.K 195, 34650, İstanbul, Turkey

    M. Memet Özek

Authors
  1. Funda Çorapçíoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Memet Özek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aydın Sav
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Deniz Üren
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Memet Özek.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Çorapçíoğlu, F., Memet Özek, M., Sav, A. et al. Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. Childs Nerv Syst 22, 533–538 (2006). https://doi.org/10.1007/s00381-005-0006-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-005-0006-2

Keywords

Search

Navigation