Skip to main content
SpringerLink
Log in

Surgery of tumors of the cerebellum and prefrontal cortex, and sensory memory and motor planning disturbances in children

  • Original Paper
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Object

This study addressed the integration of sensory short-term memory (SSTM) and motor planning (MP) in the lateral cerebellar region, where the dentate nucleus is localized, and in the prefrontal cortex (PF).

Methods

Boucher and Lewis's test of SSTM and MP was administered pre- and postsurgically to 8 patients of either sex, between 5 and 19 years of age, with tumors of the cerebellum, PF (area 9 medial) or the parieto-occipital region, and on one occasion to 8 corresponding controls.

Results

Whereas lesions of the midline portions of the cerebellum and of the parietal-occipital region did not appear to cause any cognitive defects, patients with lesions affecting either the lateral cerebellar region or PF exhibited statistically significant deficits of SSTM and MP.

Conclusions

The lateral cerebellum seems to act in concert with PF to integrate different cognitive activities related to holding objects in SSTM and planning motor strategies in reference to them.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

References

  1. Boucher J, Lewis V (1989) Memory impairment in relatively able autistic children. J Child Psychol Psychiatry 30:99–122

    CAS  PubMed  Google Scholar 

  2. Chaisuksunt V, Zhang Y, Anderson PN, Campbell G, Vaudano E, Schachner M, Lieberman AR (2000) Axonal regeneration from CNS neurons in the cerebellum and brainstem of adult rats: correlation with the patterns of expression and distribution of messenger RNAs for L1, CHL1, c-jun and growth associated protein-23. Neuroscience 100:87–108

    CAS  PubMed  Google Scholar 

  3. Courchesne E, Townsend J, Saitoh O (1994) The brain in infantile autism: posterior fossa structures are abnormal. Neurology 44:214–223

    CAS  PubMed  Google Scholar 

  4. Fuster JM (2000) Prefrontal neurons in networks of executive memory. Brain Res Bull 52:331–336

    CAS  PubMed  Google Scholar 

  5. Jenkins IH, Brooks DJ, Nixon PD, Frackowiak RS, Passingham RE (1994) Motor sequence learning: a study with PET. J Neurosci 14:3775–3790

    CAS  PubMed  Google Scholar 

  6. Jueptner M, Krukenberg M (2001) Motor system: cortex, basal ganglia, and cerebellum. Neuroimaging Clin N Am 11:203–219

    CAS  PubMed  Google Scholar 

  7. Jueptner M, Weiller C (1998) A review of differences between basal ganglia and cerebellar control of movements as revealed by functional imaging studies. Brain 121:1437–1449

    PubMed  Google Scholar 

  8. Jueptner M, Stephan KM, Frith CD, Brooks DJ, Frackowiak RS, Passingham RE (1997) Anatomy of motor learning. I. Frontal cortex and attention to action. J Neurophysiol 77:1313–1324

    CAS  PubMed  Google Scholar 

  9. Jueptner M, Frith CD, Brooks DJ, Frackowiak RS, Passingham RE (1997) Anatomy of motor learning. II. Subcortical structures and learning by trial and error. J Neurophysiol 77:1325–1337

    CAS  PubMed  Google Scholar 

  10. Kawamura K, Brodal A (1973) The tecto-pontine projection in the cat: an experimental anatomical study with comments on pathways for teleceptive impulses to the cerebellum. J Comp Neurol 149:371–390

    CAS  PubMed  Google Scholar 

  11. Konishi S, Uchida I, Okuaki T, Machida T, Shirouzu I, Miyashita Y (2002) Neural correlates of recency judgment. J Neurosci 22:9549–9555

    PubMed  Google Scholar 

  12. Lalonde R, Boetz MI (1990) The cerebellum and learning processes in animals. Brain Res Rev 15:325–332

    CAS  PubMed  Google Scholar 

  13. Lazareff JA, Castro-Sierra E (1996) Preoperative and postoperative analysis of visual and auditory memory in children with cerebellar tumors. Childs Nerv Syst 12:81–86

    CAS  PubMed  Google Scholar 

  14. Lotze M, Montoya P, Erb M, Hülsmann E, Flor H, Klose U, Birbaumer N, Grodd W (1999) Activation of cortical and cerebellar motor areas during executed and imagined hand movements: an fMRI study. J Cogn Neurosci 11:491–501

    CAS  PubMed  Google Scholar 

  15. Mason MR, Lieberman AR, Grenningloh G, Anderson PN (2002) Transcriptional upregulation of SCG and GAP-43 is correlated with regeneration of the axons of peripheral and central neurons in vivo. Mol Cell Neurosci 20:595–615

    CAS  PubMed  Google Scholar 

  16. Middleton FA, Strick PL (2000) Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res Brain Res Rev 31:236–250

    Article  CAS  PubMed  Google Scholar 

  17. Middleton FA, Strick PL (2001) Cerebellar projections to prefrontal cortex of the primate. J Neurosci 21:700–712

    CAS  PubMed  Google Scholar 

  18. Robertson EM, Pascual-Leone A (2001) Aspects of sensory guidance in sequence learning. Exp Brain Res 137:336–345

    CAS  PubMed  Google Scholar 

  19. Thoenissen D, Zilles K, Toni I (2002) Differential involvement of parietal and precentral regions in movement preparation and motor intention. J Neurosci 22:9024–9034

    CAS  PubMed  Google Scholar 

  20. Wagner AD (1999) Working memory contributions to human learning and remembering. Neuron 22:19–22

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Psychoacoustics and Auditory Physiology, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, 06720 , México D.F., Mexico

    Eduardo Castro-Sierra

  2. Department of Neurosurgery, Hospital Infantil de México Federico Gómez, Dr. Márquez No. 162, 06720, México D.F., Mexico

    Fernando Chico-Ponce de León & Luis F. Gordillo-Domínguez

  3. Faculty of Psychology, National Autonomous University of Mexico, 04100, México D.F., Mexico

    Rocío Raya-Gutiérrez

Authors
  1. Eduardo Castro-Sierra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fernando Chico-Ponce de León
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luis F. Gordillo-Domínguez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rocío Raya-Gutiérrez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eduardo Castro-Sierra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Castro-Sierra, E., Chico-Ponce de León, F., Gordillo-Domínguez, L.F. et al. Surgery of tumors of the cerebellum and prefrontal cortex, and sensory memory and motor planning disturbances in children. Childs Nerv Syst 19, 736–743 (2003). https://doi.org/10.1007/s00381-003-0826-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-003-0826-x

Keywords

Search

Navigation