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Dendritic architecture of corticothalamic neurons in a rat model of microgyria

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Abstract

Materials and methods. Freezing lesions of the sensorimotor cortex resembling focal human microgyria were carried out in newborn rats on first postnatal day (P1). The fine architecture of dendritic trees of corticothalamic neurons was studied in microgyric animals on P90.

Results and discussion. Compared with controls, layer 5 corticothalamic neurons located in the cortex surrounding the experimental lesion display longer basal dendrites. This finding is discussed with reference to earlier results on dendrites of layer 3 associative neurons, which, in contrast to those of corticothalamic neurons, appear to be markedly simplified.

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Authors and Affiliations

  1. Institute of Neurosurgery, Catholic University School of Medicine, Largo A. Gemelli, 8, 00168 Rome, Italy, , , , ,

    Federico Di Rocco & Concezio Di Rocco

  2. Institute of Anatomy, Catholic University School of Medicine, Largo F. Vito, 1, 00168 Rome, Italy, , , , ,

    Stefano Giannetti, Pierpaolo Gaglini & Alberto Granato

Authors
  1. Federico Di Rocco
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  2. Stefano Giannetti
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  3. Pierpaolo Gaglini
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  4. Concezio Di Rocco
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  5. Alberto Granato
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Di Rocco, F., Giannetti, S., Gaglini, P. et al. Dendritic architecture of corticothalamic neurons in a rat model of microgyria. Childs Nerv Syst 18, 690–693 (2002). https://doi.org/10.1007/s00381-002-0682-0

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  • DOI: https://doi.org/10.1007/s00381-002-0682-0

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