Abstract
Materials and methods. The expression and severity of hydrocephalus was characterized in LEW/Jms rats with inherited hydrocephalus.
Results. The frequency of overt disease (lethal) was 27.7%, but varied depending on breeding line. It increased to 31.5% when rats with mild disease were included. Most breeding pairs (48/51) produced hydrocephalic offspring with significantly more males than females affected. Some adult rats were also found to have mild (nonlethal) ventricular dilatation. When bred to Fisher F344 rats, 3% of the F1 progeny had overt hydrocephalus, indicating that the trait is not recessive. Overt hydrocephalus was 9–20% in N2 rats (F1 rats × LEW/Jms). The frequency of hydrocephalus and the presence of an excess of hydrocephalic males, varied depending on the direction of the cross. Mild hydrocephalus in N2 rats was 3.1%.
Conclusion. It is concluded that the inheritance of hydrocephalus in LEW/Jms strain is probably not mendelian recessive but may be semidominant or involve more than one gene and has a male bias indicating possible linkage to sex chromosomes.
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Jones, H.C., Carter, B.J. & Morel, L. Characteristics of hydrocephalus expression in the LEW/Jms rat strain with inherited disease. Childs Nerv Syst 19, 11–18 (2003). https://doi.org/10.1007/s00381-002-0671-3
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DOI: https://doi.org/10.1007/s00381-002-0671-3