Abstract
Diastolic wall strain (DWS), an echocardiographic index based on linear elasticity theory, has been identified as a predictor of heart failure (HF) in patients with sinus rhythm. However, its effectiveness in atrial fibrillation (AF) patients remains uncertain. This study aims to assess DWS as a predictor of HF in AF patients with preserved ejection fraction. We analysed a prospective database of AF patients undergoing transthoracic echocardiography. AF patients with reduced left ventricular ejection fraction (< 50%), posterior wall motion abnormality, hypertrophic cardiomyopathy, valvular heart disease, pericardial disease, congenital heart disease, or history of pacemaker/implantable cardioverter-defibrillator implantation or cardiac surgery were excluded. The study followed patients until HF development, death, or last visit. Follow-up for patients who underwent catheter ablation was censored on the date of their procedure. HF was ascertained based on the Framingham criteria. DWS was calculated using a validated formula: DWS = (PWs -PWd)/PWs, where PWs is the posterior wall thickness at end-systole and PWd is the posterior wall thickness at end-diastole. Among 411 study patients (mean age 69.6 years, 66% men), 20 (5%) was underwent catheter ablation and 57 (14%) developed HF during a mean follow-up of 82 months. Cox-proportional hazards demonstrated that low DWS (≤ 0.33) significantly predicted HF events (hazard ratio [HR] 3.28, 95% confidence interval [CI]) 1.81–5.94, P < 0.0001), independent of age (per 10 years; HR 1.99, 95% CI 1.35–2.93, P < 0.001), indexed left ventricular mass (per 10 g/m2; HR 1.16, 95% CI 1.05–1.27, P < 0.01), and indexed left atrial volume (per 10 mL/m2; HR 1.14, 95% CI 1.04–1.24, P < 0.01). Additionally, global log-likelihood ratio chi-square statistics indicated that DWS incrementally predicts HF development beyond age, indexed left ventricular mass, and left atrial volume (P < 0.001).
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Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, Gillum RF, Kim YH, McAnulty JH Jr., Zheng ZJ, Forouzanfar MH, Naghavi M, Mensah GA, Ezzati M, Murray CJ (2014) Worldwide epidemiology of atrial fibrillation: a global burden of Disease 2010 study. Circulation 129:837–847
McManus DD, Rienstra M, Benjamin EJ (2012) An update on the prognosis of patients with atrial fibrillation. Circulation 126:e143–146
Ruddox V, Sandven I, Munkhaugen J, Skattebu J, Edvardsen T, Otterstad JE (2017) Atrial fibrillation and the risk for myocardial infarction, all-cause mortality and heart failure: a systematic review and meta-analysis. Eur J Prev Cardiol 24:1555–1566
Magnussen C, Niiranen TJ, Ojeda FM, Gianfagna F, Blankenberg S, Njølstad I, Vartiainen E, Sans S, Pasterkamp G, Hughes M, Costanzo S, Donati MB, Jousilahti P, Linneberg A, Palosaari T, de Gaetano G, Bobak M, den Ruijter HM, Mathiesen E, Jørgensen T, Söderberg S, Kuulasmaa K, Zeller T, Iacoviello L, Salomaa V, Schnabel RB (2017) Sex differences and similarities in Atrial Fibrillation Epidemiology, Risk factors, and mortality in community cohorts: results from the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe). Circulation 136:1588–1597
Miyasaka Y, Barnes ME, Gersh BJ, Cha SS, Bailey KR, Abhayaratna W, Seward JB, Iwasaka T, Tsang TS (2006) Incidence and mortality risk of congestive heart failure in atrial fibrillation patients: a community-based study over two decades. Eur Heart J 27:936–941
Piccini JP, Hammill BG, Sinner MF, Hernandez AF, Walkey AJ, Benjamin EJ, Curtis LH, Heckbert SR (2014) Clinical course of atrial fibrillation in older adults: the importance of cardiovascular events beyond stroke. Eur Heart J 35:250–256
Sartipy U, Dahlström U, Fu M, Lund LH (2017) Atrial fibrillation in heart failure with Preserved, mid-range, and reduced ejection fraction. JACC Heart Fail 5:565–574
Wang TJ, Larson MG, Levy D, Vasan RS, Leip EP, Wolf PA, D’Agostino RB, Murabito JM, Kannel WB, Benjamin EJ (2003) Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation 107:2920–2925
Bassand JP, Accetta G, Camm AJ, Cools F, Fitzmaurice DA, Fox KA, Goldhaber SZ, Goto S, Haas S, Hacke W, Kayani G, Mantovani LG, Misselwitz F, Ten Cate H, Turpie AG, Verheugt FW, Kakkar AK, Investigators G-A (2016) Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF. Eur Heart J 37:2882–2889
Gómez-Outes A, Lagunar-Ruíz J, Terleira-Fernández AI, Calvo-Rojas G, Suárez-Gea ML, Vargas-Castrillón E (2016) Causes of death in anticoagulated patients with Atrial Fibrillation. J Am Coll Cardiol 68:2508–2521
Takeda Y, Sakata Y, Higashimori M, Mano T, Nishio M, Ohtani T, Hori M, Masuyama T, Kaneko M, Yamamoto K (2009) Noninvasive assessment of wall distensibility with the evaluation of diastolic epicardial movement. J Card Fail 15:68–77
Tsujimoto S, Miyasaka Y, Suwa Y, Taniguchi N, Kittaka S, Yamamoto K, Shiojima I (2019) Diastolic wall strain as a predictor of age-related cardiovascular events in patients with preserved left ventricular ejection fraction. Heart Vessels 34:784–792
McKee PA, Castelli WP, McNamara PM, Kannel WB (1971) The natural history of congestive heart failure: the Framingham study. N Engl J Med 285:1441–1446
Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28:1–39e14
Bunting KV, Gill SK, Sitch A, Mehta S, O’Connor K, Lip GY, Kirchhof P, Strauss VY, Rahimi K, Camm AJ, Stanbury M, Griffith M, Townend JN, Gkoutos GV, Karwath A, Steeds RP, Kotecha D (2021) Improving the diagnosis of heart failure in patients with atrial fibrillation. Heart 107:902–908
Kotecha D, Mohamed M, Shantsila E, Popescu BA, Steeds RP (2017) Is echocardiography valid and reproducible in patients with atrial fibrillation? A systematic review. Europace 19:1427–1438
Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N (1986) Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 57:450–458
Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, Kamel H, Kernan WN, Kittner SJ, Leira EC, Lennon O, Meschia JF, Nguyen TN, Pollak PM, Santangeli P, Sharrief AZ, Smith SC Jr., Turan TN, Williams LS (2021) 2021 Guideline for the Prevention of Stroke in patients with stroke and transient ischemic attack: a Guideline from the American Heart Association/American Stroke Association. Stroke 52:e364–e467
Tsiartas E, Samaras A, Papazoglou AS, Kartas A, Moysidis DV, Gemousakakis E, Kamzolas O, Bekiaridou A, Doundoulakis I, Tzikas A, Giannakoulas G (2023) Changes in CHA2DS2-VASc score and risk of ischemic stroke among patients with atrial fibrillation. Heart Vessels 38:1267–1276
Chamberlain AM, Gersh BJ, Alonso A, Chen LY, Berardi C, Manemann SM, Killian JM, Weston SA, Roger VL (2015) Decade-long trends in atrial fibrillation incidence and survival: a community study. Am J Med 128:260–267e26
Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC, Ikonomidis JS, Khavjou O, Konstam MA, Maddox TM, Nichol G, Pham M, Piña IL, Trogdon JG (2013) Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail 6:606–619
Dzeshka MS, Lip GY, Snezhitskiy V, Shantsila E (2015) Cardiac fibrosis in patients with Atrial Fibrillation: mechanisms and clinical implications. J Am Coll Cardiol 66:943–959
Taniguchi N, Miyasaka Y, Suwa Y, Harada S, Nakai E, Shiojima I (2020) Heart failure in Atrial Fibrillation - An Update on clinical and echocardiographic implications. Circ J 84:1212–1217
Tsang TS, Gersh BJ, Appleton CP, Tajik AJ, Barnes ME, Bailey KR, Oh JK, Leibson C, Montgomery SC, Seward JB (2002) Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women. J Am Coll Cardiol 40:1636–1644
Pandey A, Kim S, Moore C, Thomas L, Gersh B, Allen LA, Kowey PR, Mahaffey KW, Hylek E, Peterson ED, Piccini JP, Fonarow GC (2017) Predictors and prognostic implications of Incident Heart failure in patients with prevalent Atrial Fibrillation. JACC Heart Fail 5:44–52
Suksaranjit P, McGann CJ, Akoum N, Biskupiak J, Stoddard GJ, Kholmovski EG, Navaravong L, Rassa A, Bieging E, Chang L, Haider I, Marrouche NF, Wilson BD (2016) Prognostic implications of Left Ventricular Scar determined by late Gadolinium enhanced Cardiac magnetic resonance in patients with Atrial Fibrillation. Am J Cardiol 118:991–997
Zhao L, Li S, Ma X, Bai R, Liu N, Li N, Schoenhagen P, Ma C (2019) Prognostic significance of left ventricular fibrosis assessed by T1 mapping in patients with Atrial Fibrillation and Heart failure. Sci Rep 9:13374
Liu YW, Lee WH, Lin CC, Huang YY, Lee WT, Lee CH, Tsai LM, Chen JH, Tsai WC (2014) Left ventricular diastolic wall strain and myocardial fibrosis in treated hypertension. Int J Cardiol 172:e304–306
Taniguchi N, Miyasaka Y, Suwa Y, Harada S, Nakai E, Kawazoe K, Shiojima I (2019) Usefulness of Left Atrial volume as an independent predictor of Development of Heart failure in patients with Atrial Fibrillation. Am J Cardiol 124:1430–1435
Uetake S, Maruyama M, Mitsuishi T, Takahashi K, Miyauchi Y, Seino Y, Shimizu W (2019) Diastolic wall strain predicts progression from paroxysmal to persistent or permanent atrial fibrillation in structurally normal hearts. J Cardiol 74:339–346
Kawaji T, Shizuta S, Yamaji K, Tanaka M, Kitano K, Aizawa T, Yamagami S, Komasa A, Yoshizawa T, Kato M, Yokomatsu T, Miki S, Ono K, Morimoto T, Kimura T (2022) Matched comparison of catheter ablation versus conservative management for atrial fibrillation. Heart Vessels 37:1242–1254
Modin D, Claggett B, Gislason G, Hansen ML, Worck R, Johannessen A, Hansen J, Svendsen JH, Pallisgaard JL, Schou M, Køber L, Solomon SD, Torp-Pedersen C, Biering-Sørensen T (2020) Catheter ablation for atrial fibrillation is associated with lower incidence of heart failure and death. Europace 22:74–83
Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M (2021) Empagliflozin in Heart failure with a preserved ejection fraction. N Engl J Med 385:1451–1461
Packer M, Butler J, Zannad F, Filippatos G, Ferreira JP, Pocock SJ, Carson P, Anand I, Doehner W, Haass M, Komajda M, Miller A, Pehrson S, Teerlink JR, Schnaidt S, Zeller C, Schnee JM, Anker SD (2021) Effect of Empagliflozin on worsening heart failure events in patients with heart failure and preserved ejection fraction: EMPEROR-Preserved trial. Circulation 144:1284–1294
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This study was supported in part by Grant-in-Aid for Scientific Research ©, 26461096, from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Tokyo Japan).
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Study concept and design: Yoko Miyasaka, Naoki Taniguchi. Acquisition of data: Naoki Taniguchi, Yoshinobu Suwa, Eri Nakai. Analysis and interpretation of data: Naoki Taniguchi, Yoko Miyasaka. Drafting of the manuscript: Naoki Taniguchi, Yoko Miyasaka, Ichiro Shiojima. Critical revision of the manuscript for important intellectual content: Yoko Miyasaka, Naoki Taniguchi, Yoshinobu Suwa, Shoko Harada, Eri Nakai, Hiromi Otagaki, Ichiro Shiojima. Obtained funding: Yoko Miyasaka.
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Taniguchi, N., Miyasaka, Y., Suwa, Y. et al. Incremental value of diastolic wall strain in predicting heart failure events in patients with atrial fibrillation. Heart Vessels (2024). https://doi.org/10.1007/s00380-024-02401-w
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DOI: https://doi.org/10.1007/s00380-024-02401-w