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Impact of moderate to vigorous intensity physical activity on change in renal function in patients after acute myocardial infarction

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Abstract

Acute myocardial infarction (AMI) is associated with a decline in renal function. This study aimed to investigate the impact of engaging in moderate to vigorous intensity physical activity (MVPA) for more than 30 min per day on changes in renal function during the first 3 months after AMI onset. A prospective, observational study was conducted, enrolling 87 patients (75 men; average age, 65.2 ± 12.5 years) who had experienced AMI. The cystatin C-based estimated glomerular filtration rate (eGFRcys) was collected at and 3 months after discharge. Daily MVPA was measured using triaxial accelerometers at a threshold of 3.0 Metabolic equivalent of the task for 3 months. Generalized estimating equations (GEE) were applied to evaluate the longitudinal association between the number of days per week of MVPA for 30 min or more and within-patient changes in eGFRcys. The patients were categorized into three groups based on their MVPA engagement days: 0 days (n = 20), 1–2 days (n = 14), and 3–7 days (n = 53) groups. After adjusting for potential confounding variables, GEE analysis revealed that the eGFRcys slope over 3 months was significantly higher in the 3–7 days group than in 0 days group (B = 2.9, (95% confidence interval: 1.5–4.2), p < 0.001). Similar results were obtained when MVPA time thresholds were set to 40 and 60 min. These findings suggest a significant positive effect of engaging in MVPA for 30 min or more for 3–7 days per week in the improvement of renal function after AMI onset.

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Abbreviations

AMI:

acute myocardial infarction

AT:

aerobic threshold

BNP:

B-type natriuretic peptide

CKD:

chronic kidney disease

eGFR:

estimated glomerular filtration rate

eGFRcreat:

creatinine-based estimated glomerular filtration rate

eGFRcys:

cystatin C-based estimated glomerular filtration rate

GEE:

generalized estimating equation

LVEF:

left ventricular ejection fraction

MVPA:

moderate to vigorous intensity physical activity

PCI:

percutaneous coronary intervention

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Acknowledgements

The authors would like to express their gratitude to all the patients whose participation made this investigation possible, as well as to all colleagues at Southern Tohoku General Hospital for their valuable contributions to the medical care of the patients.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Physical Therapy, Fukushima Medical University School of Health Sciences, 10-6, Sakaemachi, Fukushima, 960-8516, Japan

    Toshimi Sato & Shinichiro Morishita

  2. Department of Cardiology, Southern Tohoku General Hospital, Koriyama, Japan

    Masahiro Ono, Keiichi Kawamura, Wakako Naganuma & Namiko Shishito

  3. Department of Rehabilitation, Ohta General Hospital Foundation, Ohta Nishinouchi Hospital, Koriyama, Japan

    Yuichiro Sasamoto

  4. Yamagata Prefectural University of Health Sciences, Yamagata, Japan

    Masahiro Kohzuki

  5. Tohoku University Graduate School of Medicine, Sendai, Japan

    Masahiro Kohzuki

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  1. Toshimi Sato
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Contributions

Toshimi Sato and Masahiro Kohzuki contributed to the conception or design of the work. All authors contributed to the acquisition, analysis, or interpretation of data for the work. Toshimi Sato drafted the manuscript. Masahiro Ono, Keiichi Kawamura, Wakako Naganuma, Namiko Shishito, Shinichiro Morishita, Yuichiro Sasamotoa and Masahiro Kohzuki critically revised the manuscript. All gave final approval and agree to be accountable for all aspects of work ensuring integrity and accuracy.

Corresponding author

Correspondence to Toshimi Sato.

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Ethics approval and consent to participate

The study was conducted in accordance with the principles of the Declaration of Helsinki. It received approval from the Ethics Committee of Tohoku University Graduate School of Medicine (Approval No. 2016-1‐683) and the Ethics Committee of Southern Tohoku General Hospital (Approval No. D16‐14).

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All participants provided written informed consent after receiving an explanation of the study’s purpose and protocol.

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Sato, T., Ono, M., Kawamura, K. et al. Impact of moderate to vigorous intensity physical activity on change in renal function in patients after acute myocardial infarction. Heart Vessels 39, 393–403 (2024). https://doi.org/10.1007/s00380-023-02354-6

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