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Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

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Abstract

Recurrence of left ventricular (LV) remodeling after surgical ventricular reconstruction (SVR) for ischemic cardiomyopathy has been reported to be partially attributed to autophagy. We aimed to examine the effects of trehalose, an autophagy inducer, on the recurrence of LV remodeling after SVR. After SVR in rats with ICM, trehalose was orally administered. The changes in LV end-diastolic dimension (LVEDD) and fractional shortening (FS) were evaluated. The activation of myocardial autophagy was also estimated by autophagy markers: microtubule-associated light chain 3 II (LC3-II) and p62; the former usually increases and the latter decreases if autophagy is activated. Significant LV reverse remodeling was observed early after SVR. On the other hand, the 28th postoperative day SVR + trehalose was associated with smaller LVEDD and better FS than SVR alone (LVEDD, P = 0.043; FS, P < 0.01). LC3-II increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01). In conclusion, trehalose attenuated the recurrence of LV remodeling and changed autophagy markers after SVR in rats with ICM. Trehalose may be a candidate for adjuvant therapy to retain the effects of SVR.

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Acknowledgements

We thank Editage for English language editing.

Funding

This work was supported by Japan Heart Foundation Research Grant 2015 [to Yasushige Shingu]; Mochida Memorial Foundation for Medical and Pharmaceutical Research 2016 [to Yasushige Shingu]. Japan Heart Foundation Research Grant 2015, Mochida Memorial Foundation for Medical and Pharmaceutical Research 2016

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Authors and Affiliations

  1. Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido University, Kita 15, Nishi 7, Kitaku, Sapporo, 060-8638, Japan

    Tetsuya Hieda, Yasushige Shingu & Satoru Wakasa

  2. Department of Cardiovascular Surgery, Obihiro Kosei Hospital, Obihiro, Japan

    Satoshi Sugimoto

  3. Department of Cardiovascular Surgery, Hokkaido Medical Center for Child Health and Rehabilitation, Sapporo, Japan

    Hidetsugu Asai

  4. Department of Cardiovascular Surgery, Kinikyo Chuo Hospital, Sapporo, Japan

    Tomoji Yamakawa

Authors
  1. Tetsuya Hieda
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  2. Yasushige Shingu
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  3. Satoshi Sugimoto
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  4. Hidetsugu Asai
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  5. Tomoji Yamakawa
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  6. Satoru Wakasa
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Contributions

All authors contributed to the conception and design of the study. Material preparation, date collection and analysis were performed by all authors. The first draft of the manuscript was written by Tetsuya Hieda, and all authors commented on previous version of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Yasushige Shingu.

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Hieda, T., Shingu, Y., Sugimoto, S. et al. Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy. Heart Vessels 37, 528–537 (2022). https://doi.org/10.1007/s00380-021-01990-0

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  • DOI: https://doi.org/10.1007/s00380-021-01990-0

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